Associations between 6-minute walk distance and physiologic measures and clinical outcomes in myositis-associated interstitial lung disease.

IF 4.4 2区医学 Q1 RHEUMATOLOGY Rheumatology Pub Date : 2025-12-01 DOI:10.1093/rheumatology/keae477

Sangmee Sharon Bae, Daniela Markovic, Didem Saygin, Daniel Sullivan, Koichi Yamaguchi, Siamak Moghadam-Kia, Chester V Oddis, Fereidoun Abtin, Grace Hyun J Kim, Galina Marder, Swamy Venuturupalli, Paul F Dellaripa, Sonye Danoff, Tracy Doyle, Gary Hunninghake, Joyce S Lee, Jeremy Falk, Cheilonda Johnson, Jonathan Goldin, Donald Tashkin, Christina Charles-Schoeman, Rohit Aggarwal

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Abstract

Objective: The 6-min walk test (6MWT) is a simple test widely used to assess sub-maximal exercise capacity in chronic respiratory diseases. We explored the relationship of 6-min walk distance (6MWD) with measurements of physiological, clinical, radiographic measures in patients with myositis-associated interstitial lung disease (MA-ILD).

Method: We analysed data from the Abatacept in Myositis Associated Interstitial Lung Disease (Attack My-ILD) study, a 48-week multicentre randomized trial of patients with anti-synthetase antibodies and active MA-ILD. 6MWD, forced vital capacity (FVC), diffusing capacity (DLCO), high-resolution CT and various physician-/patient-reported outcome measures were obtained during the trial. Spearman's correlations and repeated-measures analysis with linear mixed-effects models were used to estimate the associations between 6MWD and various physiologic, clinical and radiographic parameters both cross-sectionally and longitudinally.

Results: Twenty participants with a median age of 57 years, 55% male and 85% white were analysed. Baseline 6MWD did not associate with baseline pulmonary function tests. Repeated-measures analysis showed 6MWD over time associated with FVC over time, but not with DLCO. 6MWD over time also correlated with University of California San Diego Shortness of Breath questionnaire dyspnoea score, Borg scores, as well as global disease activity and muscle strength over time. Emotional role functioning, vitality, general health and physical functioning scores by Short Form 36 also correlated with 6MWD over time.

Conclusions: Exploratory work in a small cohort of MA-ILD demonstrated 6MWD over time associated with parallel changes in FVC and patient-reported outcomes of dyspnoea, but not with DLCO. Larger studies are needed to validate the reliability, responsiveness and utility of the 6MWT in MA-ILD.

Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT03215927.

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肌炎相关间质性肺病患者 6 分钟步行距离与生理指标和临床结果之间的关系。

目的6分钟步行测试（6MWT）是一种广泛用于评估慢性呼吸系统疾病患者亚最大运动能力的简单测试。我们探讨了肌炎相关间质性肺病（MA-ILD）患者 6 分钟步行距离（6MWD）与生理、临床、影像学测量的关系：我们分析了阿巴他赛普治疗肌炎相关间质性肺病（Attack My-ILD）研究的数据，该研究是一项针对抗合成酶抗体和活动性肌炎相关间质性肺病患者的为期48周的多中心随机试验。试验期间获得了6MWD、用力肺活量（FVC）、弥散能力（DLCO）、高分辨率CT以及各种医生/患者报告的结果指标。采用斯皮尔曼相关性和线性混合效应模型的重复测量分析来估计 6MWD 与各种生理、临床和放射学参数之间的横向和纵向关系：对 20 名参与者进行了分析，他们的中位年龄为 57 岁，55% 为男性，85% 为白人。基线 6MWD 与基线 PFTs 无关。重复测量分析显示，6MWD随时间变化与FVC随时间变化相关，但与DLCO无关。随着时间的推移，6MWD 也与 UCSD 呼吸困难评分、Borg 评分以及随着时间的推移，与整体疾病活动度和肌肉力量相关。情感角色功能、活力、一般健康和身体功能短表 36 评分也与 6MWD 随时间变化的情况相关：在一小批 MA-ILD 患者中进行的探索性研究表明，随着时间的推移，6MWD 与 FVC 和患者报告的呼吸困难结果的平行变化相关，但与 DLCO 无关。需要进行更大规模的研究，以验证 6MWT 在 MA-ILD 中的可靠性、响应性和实用性：临床试验注册：ClinicalTrials.gov，NCT03215927。

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来源期刊

Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

7.30%

发文量

1091

审稿时长

2 months

期刊介绍： Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.