Allostatic load in rat model: An efficient tool for evaluating and understanding aging

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-09-03 DOI:10.1111/ggi.14950

Dandan Chen, Xiaohong Deng, Yuxin Jia, Xianjun Sun, Xiaohong Duan, Shikai Yan, Jianhua Huang

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Abstract

Aim

Aging and age-related diseases are an ever-increasing social and public health problem. Allostatic load (AL) shows great potential as an interdisciplinary tool for assessing the aging of human beings but as yet lacks investigation in animal models which is our study focus at.

Methods

Here a continuous study of AL was conducted on naturally aging rats. Blood samples were collected from the rats at ages of 5, 8, 14, 18, and 21 months. Dozens of blood biochemical indicators, including serum corticosterone, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, interleukin-6, 25-hydroxyvitamin D, free fatty acid, CD3⁺ T cell count, CD4⁺/CD3⁺ T cell ratio, CD8⁺/CD3⁺ T cell ratio, and CD3/4/8⁺ T cell apoptosis, were determined.

Results

AL was scored from those indicators, and we found that AL score gradually increased with age.

Conclusions

AL can reliably reveal the cumulative and systemic changes in aging. Geriatr Gerontol Int 2024; 24: 1077–1084.

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大鼠模型中的静态负荷：评估和了解衰老的有效工具。

目的：衰老和老年相关疾病是一个日益严重的社会和公共健康问题。作为一种评估人类衰老的跨学科工具，静力负荷（AL）显示出巨大的潜力，但目前还缺乏对动物模型的研究，而这正是我们的研究重点。在大鼠 5、8、14、18 和 21 个月大时采集其血液样本。测定了血清皮质酮、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、C反应蛋白、白细胞介素-6、25-羟维生素D、游离脂肪酸、CD3+ T细胞数、CD4+/CD3+ T细胞比、CD8+/CD3+ T细胞比和CD3/4/8+ T细胞凋亡等数十项血液生化指标：根据这些指标对AL进行评分，我们发现AL评分随着年龄的增长而逐渐增加：结论：AL能可靠地揭示衰老的累积性和系统性变化。Geriatr Gerontol Int 2024; --：-----.

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