Delayed Ferumoxtran-10-Enhanced Magnetic Resonance Neurography of the Lumbosacral Plexus: Impact on Vascular Suppression and Image Quality.

IF 3.3 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Magnetic Resonance Imaging Pub Date : 2024-09-04 DOI:10.1002/jmri.29604
Malwina Kaniewska, Eva Deininger-Czermak, Falko Ensle, Olivio F Donati, Roman Guggenberger
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Abstract

Background: Intravenous Ferumoxtran-10 belongs to ultra-small superparamagnetic iron oxide particles and can be used for magnetic resonance neurography (MRN) as an alternative to other imaging methods which use contrast agents.

Purpose: To examine the impact of intravenous Ferumoxtran-10 on vascular suppression and compare image quality to gadolinium (Gd)-enhanced image acquisition in MRN of lumbosacral plexus (LS).

Study type: Prospective.

Population/subjects: 17 patients with Ferumoxtran-10-enhanced MRN, and 20 patients with Gd-enhanced MRN.

Fieldstrength/sequence: 3T/3D STIR sequence.

Assessment: Image quality, nerve visibility and vascular suppression were evaluated by 3 readers using a 5-point Likert scale.

Statistical tests: Inter-reader agreement (IRA) was calculated using intraclass coefficients (ICC). Quantitative analysis of image quality was performed by signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements and compared using Student's t-testing.

Results: Image quality, nerve visibility and vascular suppression were significantly higher for Ferumoxtran-10-enhanced MRN compared to Gd-enhanced MRN sequences (p < 0.05). IRA for image quality of nerves was good in Gd-enhanced and Ferumoxtran-10 MRN with ICC values of 0.76 and 0.89, respectively. IRA for nerve visibility was good in Gd- and Ferumoxtran-10 enhanced MR neurography (ICC 0.72 and 0.90). Mean SNR was significantly higher in Ferumoxtran-10-enhanced MRN for all analyzed structures, while mean CNR was for significantly better for S1 ganglion and femoral nerve in Ferumoxtran-10-enhanced MRN (p < 0.05).

Data conclusion: Ferumoxtran-10-enhanced MRN of the LS plexus showed significantly higher image quality and nerve visibility with better vascular suppression as compared to Gd-enhanced MRN.

Evidence level: 2 TECHNICAL EFFICACY: Stage 3.

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延迟铁葡聚糖-10 增强腰骶丛磁共振神经成像:对血管抑制和图像质量的影响。
背景:静脉注射Ferumoxtran-10属于超小型超顺磁性氧化铁颗粒,可用于磁共振神经成像(MRN),替代其他使用造影剂的成像方法。目的:研究静脉注射Ferumoxtran-10对血管抑制的影响,并比较腰骶丛(LS)MRN中钆(Gd)增强图像采集的图像质量:研究类型:前瞻性研究:17 名 Ferumoxtran-10 增强 MRN 患者和 20 名 Gd 增强 MRN 患者:场强/序列:3T/3D STIR 序列:图像质量、神经能见度和血管抑制由 3 名读者使用 5 点李克特量表进行评估:统计测试:使用类内系数(ICC)计算读者间一致性(IRA)。通过信噪比(SNR)和对比噪比(CNR)测量对图像质量进行定量分析,并使用学生 t 检验进行比较:结果:与钆增强 MRN 序列相比,铁葡聚糖-10 增强 MRN 的图像质量、神经可见度和血管抑制明显更高(p 数据结论:与钆增强 MRN 相比,铁葡聚糖-10 增强 LS 神经丛 MRN 的图像质量和神经可见度明显更高,血管抑制效果更好。
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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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Editorial for "Assessing the Performance of Artificial Intelligence Assistance for Prostate MRI: A Two-Center Study Involving Radiologists With Different Experience Levels". A Review of MRI Acoustic Noise Outputs and Hearing Protection Device Performance. Incorporating Radiologist Knowledge Into MRI Quality Metrics for Machine Learning Using Rank-Based Ratings. Issue Information Evaluation of Neurovascular Coupling in Early-Onset and Late-Onset Epilepsy of Unknown Etiology.
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