Performance of the DASF compared to other combinations of OECD NAMs for eye hazard identification of surfactants.

IF 4.5 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Altex-Alternatives To Animal Experimentation Pub Date : 2024-08-28 DOI:10.14573/altex.2406031
Nathalie Alépée, Karsten R Mewes, Takayuki Abo, Alessandra Cavarzan, Chelsea Odriscoll, Els Adriaens
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Abstract

Currently, the OECD has adopted three defined approaches (DAs) for eye hazard identification of non-surfactant liquids and solids (TG467) according to the three UN GHS categories (Cat.1, Cat.2, No Cat.). We are now expanding the applicability domain with a new DA for chemicals having surfactant (SF) properties (DASF). It is based on a combination of RhCE test methods (OECD TG492: EpiOcular™ EIT or SkinEthic™ HCE EIT) and a modification of the Short Time Exposure (STE, TG491) method. The aim of the current study was to compare the performance of the DASF with the performance of other NAMs currently included in the OECD TGs and with the classification based on the Draize eye test to identify potential additional DAs. The minimum performance criteria (75% Cat.1, 50% Cat.2, 70% No Cat.) used for the adoption of the DAs currently included in OECD TG467 were used for this purpose. The DASF identified 90.9% of Cat. 1 (N=23), 77.8% of Cat. 2 (N=9) and 76.0% of No Cat. (N=17) surfactants, meeting the minimum performance criteria. Some of the NAMs that are currently included in the OECD TGs seem promising methods to be part of a DA to identify Cat. 1 or No Cat. for eye hazard assessment of surfactants. However, the number of surfactants that have been tested to evaluate reliability and relevance was often too small. To date, the DASF is the only DA that has evaluated a sufficiently large number of surfactants and whose performance met the OECD acceptance criteria.

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DASF 与经合组织 NAMs 的其他组合相比,在识别表面活性剂对眼睛的危害方面的性能。
目前,经济合作与发展组织 (OECD) 已根据联合国全球统一制度的三个类别(第 1 类、第 2 类和无类别),采用了三种定义方法 (DA),用于非表面活性剂液体和固体的眼睛危害识别 (TG467)。目前,我们正在通过一项针对具有表面活性剂(SF)特性的化学品的新检测方法(DASF)来扩大适用范围。它基于 RhCE 测试方法(OECD TG492:EpiOcular™ EIT 或 SkinEthic™ HCE EIT)和短时间暴露 (STE, TG491) 方法的改进。当前研究的目的是将 DASF 的性能与目前列入 OECD TG 的其他 NAM 的性能以及基于 Draize 眼睛测试的分类进行比较,以确定潜在的其他 DA。为此,我们采用了目前 OECD TG467 中包含的 DAs 的最低性能标准(75% Cat.1、50% Cat.2、70% No Cat.)。DASF 确定了 90.9% 的 Cat.1(总数=23),77.8%的Cat.2(9 种)和 76.0% 的无类别(17 种)表面活性剂。(N=17) 表面活性剂符合最低性能标准。目前列入经合组织技术指导文件的一些无机表面活性剂似乎很有希望成为 DA 的一部分,以确定眼危害 Cat.1 或无类别的表面活性剂。不过,为评估可靠性和相关性而进行测试的表面活性剂数量往往太少。迄今为止,DASF 是唯一对足够多的表面活性剂进行过评估,且其性能符合 OECD 验收标准的 DA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Altex-Alternatives To Animal Experimentation
Altex-Alternatives To Animal Experimentation MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
7.70
自引率
8.90%
发文量
89
审稿时长
2 months
期刊介绍: ALTEX publishes original articles, short communications, reviews, as well as news and comments and meeting reports. Manuscripts submitted to ALTEX are evaluated by two expert reviewers. The evaluation takes into account the scientific merit of a manuscript and its contribution to animal welfare and the 3R principle.
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