Recent advances in the chemistry of selenophenopyrimidine heterocycles: Synthesis, reactivity, and biological activity

Abstract

Undoubtedly, pyrimidine and selenophene stand as invaluable heterocyclic compounds pivotal in the quest for novel drug development. The fusion of selenophene and pyrimidine motifs into hybrid architectures has ushered in a realm of promising pharmacological potentialities. This amalgamation has given rise to selenophenopyrimidine derivatives, such as selenopheno[2,3-d]pyrimidine, selenopheno[3,4-d]pyrimidine, and selenopheno[3,2-d]pyrimidine, each boasting intriguing properties. Synthesizing selenophenopyrimidines encompasses diverse chemical pathways, including one-pot multi-component reactions, Vilsmeier-Haack reactions, Gewald reactions, and Suzuki cross-coupling methodologies.