Dynamic compliance penis enlargement patch

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL Bioactive Materials Pub Date : 2024-09-03 DOI:10.1016/j.bioactmat.2024.08.039

Rui Zheng , Wenwen Zhong , Muyuan Chai , Xuetao Shi

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Abstract

Men are particularly sensitive to penis size, especially those with a deformed or injured penis. This can lead to a strong desire for penis enlargement surgery. Given the ethical sensitivities of the penis, penile implants need to be developed with both efficacy and safety. In this study, a polyvinyl alcohol (PVA) patch for penile enlargement prepared via cyclic freeze‒thaw cycles and alkaline treatment. The PVA hydrogels treated with 5 M NaOH had the best mechanical properties and stability. A negative Poisson's ratio structure is incorporated into the design of the enlargement patch, which allows it to conform well to the deformation of the penis. In rabbit models, the enlarged patches can effectively enlarge the penis without degradation or fibrosis while maintaining long-term stability in vivo. This innovation not only provides a safe option for patients in need of penile enlargement but also promises to make a broader contribution to the field of dynamic tissue repair.

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动态顺应性阴茎增大贴片

男性对阴茎大小特别敏感，尤其是那些阴茎畸形或受伤的男性。这可能会导致他们对阴茎增大手术的强烈渴望。鉴于阴茎在伦理上的敏感性，需要开发出既有效又安全的阴茎植入物。在这项研究中，一种用于阴茎增大的聚乙烯醇（PVA）贴片通过循环冻融循环和碱性处理制备而成。经 5 M NaOH 处理的 PVA 水凝胶具有最佳的机械性能和稳定性。阴茎增大贴片的设计中采用了负泊松比结构，使其能够很好地适应阴茎的变形。在兔子模型中，增大贴片能有效增大阴茎，不会发生降解或纤维化，同时在体内保持长期稳定性。这项创新不仅为需要增大阴茎的患者提供了一种安全的选择，而且有望为动态组织修复领域做出更广泛的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.