Photocatalysed eosin Y mediated synthesis of biologically potent 4 (3H)-quinazolinone

Pravin Kumar Singh , Rohit Kumar , Vishal Srivastava , Praveen Pratap Singh
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Abstract

An environmentally benign green and metal-free visible light mediated approach for the synthesis of biologically potent 4(3H)-quinazolinone through multicomponent reaction of readily available starting materials potassium salt of anthranilic acid, aryl carboxylic acid, aliphatic/aromatic amine catalyzed by Eosin-Y has been developed with wide range of applications in pharmaceutical. Integrated process reduces the mechanical loss of the intermediate during the process of isolation.

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光催化曙红 Y 介导的生物活性 4 (3H) - 喹唑啉酮的合成
在 Eosin-Y 催化下,通过易得的起始原料蒽酸钾盐、芳基羧酸、脂肪族/芳香族胺的多组分反应,开发出了一种绿色环保、无金属的可见光介导方法,用于合成具有生物药效的 4(3H)-喹唑啉酮,该方法在制药领域有着广泛的应用。一体化工艺减少了中间体在分离过程中的机械损失。
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