Dimethylsulfoniopropionate (DMSP): From Biochemistry to Global Ecological Significance.

IF 8.5 1区 生物学 Q1 MICROBIOLOGY Annual review of microbiology Pub Date : 2024-09-04 DOI:10.1146/annurev-micro-041222-024055
Chun-Yang Li, Hai-Yan Cao, Rocky D Payet, Jonathan D Todd, Yu-Zhong Zhang
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Abstract

Dimethylsulfoniopropionate (DMSP) is one of Earth's most abundant organosulfur compounds with important roles in stress tolerance, chemotaxis, global carbon and sulfur cycling, and climate-active gas production. Diverse marine prokaryotes and eukaryotes produce DMSP via three known pathways (methylation, transamination, and decarboxylation) and metabolize DMSP via three further pathways (demethylation, cleavage, and oxidation). Over 20 key enzymes from these pathways have been identified to inform on the biodiversity and importance of DMSP cycling. The last dozen years have seen significant changes in our understanding of the enzymology and molecular mechanisms of these DMSP cycling enzymes through the application of biochemistry and structural biology. This has yielded more than 10 crystal structures and, in many cases, detailed explanations as to how and why organisms synthesis and metabolize DMSP. In this review, we describe recent progress in biochemical and mechanistic understandings of DMSP synthesis and metabolism, highlighting the important knowledge gleaned and current challenges that warrant further exploration.

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二甲基硫代丙酸酯(DMSP):从生物化学到全球生态意义。
二甲基硫代丙酸酯(DMSP)是地球上最丰富的有机硫化合物之一,在应激耐受性、趋化性、全球碳和硫循环以及气候活性气体产生方面具有重要作用。多种海洋原核生物和真核生物通过三种已知途径(甲基化、转胺和脱羧)产生 DMSP,并通过另外三种途径(脱甲基化、裂解和氧化)代谢 DMSP。这些途径中的 20 多种关键酶已被确定,为 DMSP 循环的生物多样性和重要性提供了信息。在过去的十几年中,通过生物化学和结构生物学的应用,我们对这些 DMSP 循环酶的酶学和分子机制的理解发生了重大变化。这已经产生了 10 多个晶体结构,并在许多情况下详细解释了生物如何以及为何合成和代谢 DMSP。在这篇综述中,我们将介绍对 DMSP 合成和新陈代谢的生化和机理认识的最新进展,重点介绍已获得的重要知识以及当前需要进一步探索的挑战。
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来源期刊
Annual review of microbiology
Annual review of microbiology 生物-微生物学
CiteScore
18.10
自引率
0.00%
发文量
37
期刊介绍: Annual Review of Microbiology is a Medical and Microbiology Journal and published by Annual Reviews Inc. The Annual Review of Microbiology, in publication since 1947, covers significant developments in the field of microbiology, encompassing bacteria, archaea, viruses, and unicellular eukaryotes. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license. The Impact Factor of Annual Review of Microbiology is 10.242 (2024) Impact factor. The Annual Review of Microbiology Journal is Indexed with Pubmed, Scopus, UGC (University Grants Commission).
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