Efficacy and Safety of Low-Fluence 730-nm Picosecond Laser in the Treatment of Melasma in Chinese Patients.

IF 2.2 3区医学 Q2 DERMATOLOGY Dermatologic Surgery Pub Date : 2025-02-01 Epub Date: 2024-09-04 DOI:10.1097/DSS.0000000000004393

Rui Han, Yifang Sun, Mingshan Su

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Abstract

Background: The 730-nm picosecond laser has shown promise in treating various benign pigmentary conditions, and it is yet to be determined whether it is effective and safe for melasma.

Objective: The aim of this study was to investigate the potential benefits and risks of using the 730-nm picosecond laser to remove melasma.

Materials and methods: This is a retrospective review of all patients who presented to the clinic between April 2021 and April 2022 for the treatment of melasma with 730-nm picosecond laser alone. The efficacy of the laser was assessed based on the Melasma Area and Severity Index (MASI) score using high-resolution photographs evaluated by blinded dermatologists.

Results: A total of 25 Chinese with Fitzpatrick skin Type II to IV were included. Patients were treated for an average of 3.56 ± 0.77 treatment sessions. The mean MASI scores decreased by 33.7% from 11.38 ± 6.60 to 7.55 ± 6.08 at an average of 8.48 ± 2.16 weeks of follow-up ( p < .001). Among the patients, 1 experienced a 79% decrease, 6 had a decrease ranging from 51% to 75%, 10 had a decrease ranging from 26% to 50%, 5 had a decrease of less than 25%, and 3 experienced no changes in MASI scores. No hyper/hypopigmentation was observed.

Conclusion: Low-fluence 730-nm picosecond laser is an effective and safe modality for the treatment of melasma in Chinese patients.

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低能量 730 纳米皮秒激光治疗中国黄褐斑的有效性和安全性

背景：730纳米皮秒激光在治疗各种良性色素性疾病方面已显示出良好的前景，但它对黄褐斑是否有效和安全还有待确定：本研究旨在调查使用 730 纳米皮秒激光去除黄褐斑的潜在益处和风险：这是一项回顾性研究，研究对象是2021年4月至2022年4月期间就诊的所有黄褐斑患者，他们都曾单独使用730纳米皮秒激光治疗黄褐斑。激光疗效根据黄褐斑面积和严重程度指数（MASI）评分进行评估，采用高分辨率照片，由皮肤科盲人医生进行评估：结果：共纳入了 25 名菲茨帕特里克皮肤 II 型至 IV 型的中国人。患者平均接受了 3.56 ± 0.77 个疗程的治疗。在平均 8.48 ± 2.16 周的随访中，MASI 平均得分从 11.38 ± 6.60 降至 7.55 ± 6.08，降幅为 33.7%（p < .001）。其中，1 名患者的评分下降了 79%，6 名患者的评分下降了 51% 至 75%，10 名患者的评分下降了 26% 至 50%，5 名患者的评分下降了不到 25%，3 名患者的 MASI 评分没有变化。没有观察到色素沉着：结论：730nm皮秒低能量激光是治疗中国黄褐斑的一种有效而安全的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.