Germline mutation rate predicts cancer mortality across 37 vertebrate species.

IF 3.3 3区 医学 Q2 EVOLUTIONARY BIOLOGY Evolution, Medicine, and Public Health Pub Date : 2024-08-19 eCollection Date: 2024-01-01 DOI:10.1093/emph/eoae016
Stefania E Kapsetaki, Zachary T Compton, Walker Mellon, Orsolya Vincze, Mathieu Giraudeau, Tara M Harrison, Lisa M Abegglen, Amy M Boddy, Carlo C Maley, Joshua D Schiffman
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Abstract

Background and objectives: Cancer develops across nearly every species. However, cancer occurs at unexpected and widely different rates throughout the animal kingdom. The reason for this variation in cancer susceptibility remains an area of intense investigation. Cancer evolves in part through the accumulation of mutations, and therefore, we hypothesized that germline mutation rates would be associated with cancer prevalence and mortality across species.

Methodology: We collected previously published data on germline mutation rate and cancer mortality data for 37 vertebrate species.

Results: Germline mutation rate was positively correlated with cancer mortality (P-value = 0.0008; R2 = 0.13). Controlling for species' average parental age, maximum longevity, adult body mass or domestication did not improve the model fit (the change (Δ) in Akaike Information Criterion (AIC) was less than 2). However, this model fit was better than a model controlling for species trophic level (ΔAIC > 2).

Conclusions and implications: The increased death rate from cancer in animals with increased germline mutation rates may suggest underlying hereditary cancer predisposition syndromes similar to those diagnosed in human patients. Species with higher germline mutation rates may benefit from close monitoring for tumors due to increased genetic risk for cancer development. Early diagnoses of cancer in these species may increase their chances of overall survival, especially for threatened and endangered species.

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种系突变率可预测 37 种脊椎动物的癌症死亡率。
背景和目的:几乎所有物种都会患癌症。然而,在整个动物王国中,癌症的发生率却出乎意料地大相径庭。这种癌症易感性差异的原因仍是一个需要深入研究的领域。癌症部分是通过突变积累演变而来的,因此,我们假设种系突变率与不同物种的癌症发病率和死亡率有关:我们收集了以前公布的 37 种脊椎动物的种系突变率数据和癌症死亡率数据:结果:种系突变率与癌症死亡率呈正相关(P值=0.0008;R2=0.13)。控制物种的平均亲代年龄、最长寿命、成年体重或驯化程度并不能提高模型的拟合度(阿凯克信息准则(AIC)的变化(Δ)小于 2)。然而,该模型的拟合优于控制物种营养级的模型(ΔAIC > 2):种系突变率越高的动物癌症死亡率越高,这可能表明其潜在的遗传性癌症易感综合征与人类患者诊断出的癌症易感综合征类似。由于癌症发生的遗传风险增加,种系突变率较高的物种可能受益于对肿瘤的密切监测。对这些物种进行癌症早期诊断可能会增加它们的总体存活机会,尤其是对受威胁和濒危物种而言。
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来源期刊
Evolution, Medicine, and Public Health
Evolution, Medicine, and Public Health Environmental Science-Health, Toxicology and Mutagenesis
CiteScore
5.40
自引率
2.70%
发文量
37
审稿时长
8 weeks
期刊介绍: About the Journal Founded by Stephen Stearns in 2013, Evolution, Medicine, and Public Health is an open access journal that publishes original, rigorous applications of evolutionary science to issues in medicine and public health. It aims to connect evolutionary biology with the health sciences to produce insights that may reduce suffering and save lives. Because evolutionary biology is a basic science that reaches across many disciplines, this journal is open to contributions on a broad range of topics.
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