PARP Inhibitor Addition to Androgen Receptor Pathway Inhibitors in Metastatic Castration-resistant Prostate Cancer Should Be Limited to BRCA Mutation Carriers

IF 4.8 2区 医学 Q1 UROLOGY & NEPHROLOGY European urology focus Pub Date : 2024-07-01 DOI:10.1016/j.euf.2024.08.005
Elena Castro
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转移性抗性前列腺癌患者在使用雄激素受体通路抑制剂的同时使用 PARP 抑制剂,应仅限于 BRCA 基因突变携带者。
对于肿瘤携带 BRCA1/2 基因改变的转移性耐受性前列腺癌患者来说,将 PARP 抑制剂和雄激素受体通路抑制剂联合用于一线治疗的潜在益处大于潜在副作用。还需要进一步的研究来确定哪些未检测到 BRCA1/2 缺陷的患者可以从这种方法中获益。
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来源期刊
European urology focus
European urology focus Medicine-Urology
CiteScore
10.40
自引率
3.70%
发文量
274
审稿时长
23 days
期刊介绍: European Urology Focus is a new sister journal to European Urology and an official publication of the European Association of Urology (EAU). EU Focus will publish original articles, opinion piece editorials and topical reviews on a wide range of urological issues such as oncology, functional urology, reconstructive urology, laparoscopy, robotic surgery, endourology, female urology, andrology, paediatric urology and sexual medicine. The editorial team welcome basic and translational research articles in the field of urological diseases. Authors may be solicited by the Editor directly. All submitted manuscripts will be peer-reviewed by a panel of experts before being considered for publication.
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