A serological survey of COVID-19 among predominantly aboriginal residents of a tourist island in southern Thailand.

IF 3.6 Q1 TROPICAL MEDICINE Tropical Medicine and Health Pub Date : 2024-09-04 DOI:10.1186/s41182-024-00617-0
Supakorn Sripaew, Kameelah Yasharad, Dzerlina S Rahari, Weiyan Feng, Zhenzhu Qian, Huynh Ngoc Thanh, Pei Li, Agus Fitriangga, Satiti Palupi Purwanto, Aye Nyein Phyu, Fangming Xianyu, Sombat Phadungvitvatthana, Wit Wichaidit, Ponlagrit Kumwichar, Virasakdi Chongsuvivatwong
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Abstract

Background: The current survey describes the seroprevalence, history of coronavirus disease 2019 (COVID-19), and vaccination status among predominantly aboriginal residents on a tourist island in southern Thailand. This information can be translated into COVID-19 vaccination and control plans for this population.

Methods: We implemented questionnaire interviews and collected blood samples from 249 residents of Lipe Island, Satun Province, in January 2022. We measured the anti-nucleocapsid protein and anti-spike (anti-S) receptor-binding protein levels of immunoglobulin (Ig) M and IgG. The differences in antibody levels among participants with different histories of vaccination and infection were analyzed using one-way analysis of variance with multiple comparisons.

Results: During the 2-year pandemic period, no island residents with COVID-19 required hospitalization despite the high prevalence of hypertension (33.3%) and diabetes mellitus (21.7%). Approximately 18.8% of the participants reported a history of COVID-19 diagnosis. In total, 95.1% of the participants had a history of complete vaccination, of which 93.5% were seropositive. The anti-S IgG geometric means (geometric standard deviation) were 3945.8 (2.0), 829.8 (9.7) AU/mL, 789.9 (5.3) AU/mL, and 22.7 (7.1) AU/mL, respectively, in participants with a history of both COVID-19 diagnosis and complete vaccination (group 1), incomplete vaccination and subsequent COVID-19 diagnosis (group 2), complete vaccination but no previous infection (group 3), or neither previous COVID-19 and complete vaccination (group 4). Significant pairwise differences in anti-S IgG levels were found between certain groups (1 vs 3, 1 vs 4, 2 vs 4, and 3 vs 4).

Conclusions: The high coverage of vaccination, high levels of population antibody titers, variable antibody levels among completely vaccinated non-infected residents, and high prevalence of non-communicable diseases (NCDs) suggested that the local health systems could control the pandemic. However, continuing surveillance, booster vaccinations, and NCD prevention programs were still required.

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对泰国南部一个旅游岛屿上以土著居民为主的人群进行 COVID-19 血清学调查。
背景:本次调查描述了泰国南部一个旅游岛屿上以原住民为主的居民的血清流行率、冠状病毒病 2019(COVID-19)病史和疫苗接种情况。这些信息可转化为针对该人群的 COVID-19 疫苗接种和控制计划:我们于 2022 年 1 月对沙吞府利佩岛的 249 名居民进行了问卷调查并采集了血样。我们测量了免疫球蛋白 (Ig) M 和 IgG 中抗核壳蛋白和抗尖峰受体结合蛋白的水平。我们采用单因素方差分析和多重比较的方法分析了不同疫苗接种史和感染史的参与者之间抗体水平的差异:结果:在为期两年的大流行期间,尽管高血压(33.3%)和糖尿病(21.7%)的发病率很高,但岛上居民中没有人因感染 COVID-19 而需要住院治疗。约 18.8% 的参与者报告了 COVID-19 诊断史。95.1%的参与者有完整的疫苗接种史,其中93.5%血清呈阳性。抗 S IgG 的几何平均数(几何标准偏差)分别为 3945.8 (2.0)、829.8 (9.7) AU/mL、789.9 (5.3) AU/mL 和 22.7 (7. 1) AU/mL。在既有 COVID-19 诊断史又完全接种过疫苗(第 1 组)、未完全接种疫苗且随后诊断出 COVID-19 (第 2 组)、完全接种疫苗但既往未感染过(第 3 组)或既往未感染过 COVID-19 也未完全接种过疫苗(第 4 组)的参与者中,抗-S 免疫球蛋白含量分别为 829.8 (9.7) AU/mL、789.9 (5.3) AU/mL 和 22.7 (7.1) AU/mL。某些组别(1 vs 3、1 vs 4、2 vs 4 和 3 vs 4)之间的抗 S IgG 水平存在明显的配对差异:疫苗接种的高覆盖率、高水平的人群抗体滴度、完全接种疫苗的非感染居民的抗体水平参差不齐以及非传染性疾病 (NCD) 的高发病率表明,当地卫生系统能够控制大流行。但是,仍然需要继续监测、加强接种疫苗和非传染性疾病预防计划。
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来源期刊
Tropical Medicine and Health
Tropical Medicine and Health TROPICAL MEDICINE-
CiteScore
7.00
自引率
2.20%
发文量
90
审稿时长
11 weeks
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