Effectiveness of C-Reactive Protein as a Tuberculosis Screening Test Among HIV-Infected Individuals - Shanghai, China, 2021-2023.

IF 4.3 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 中国疾病预防控制中心周报 Pub Date : 2024-08-30 DOI:10.46234/ccdcw2024.190

Lixin Rao, Zheyuan Wu, Jing Chen, Zhen Ning, Xin Shen

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Abstract

What is already known about this topic?: The World Health Organization (WHO) has recommended the inclusion of the C-reactive protein (CRP) test in active tuberculosis (ATB) screening algorithms among human immunodeficiency virus (HIV)-infected individuals. The performance of the CRP test in African regions has been well-documented.

What is added by this report?: This study analyzed data from a big data platform of Shanghai medical records together with infectious disease surveillance systems. We simulated a screening and plotted a receiver operating characteristic (ROC) curve, which gives the optimal cut-off value of 11.115mg/L with sensitivity and specificity of 0.784 and 0.723, respectively.

What are the implications for public health practice?: We obtained a promising perspective on screening for tuberculosis in people living with HIV (PLHIV) using the CRP test in Shanghai. Our study offers an original standpoint for following research.

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C反应蛋白作为HIV感染者肺结核筛查试验的有效性--中国上海，2021-2023年。

本专题的已知信息：世界卫生组织（WHO）建议将 C 反应蛋白（CRP）检测纳入人体免疫缺陷病毒（HIV）感染者活动性结核病（ATB）筛查算法中。CRP检测在非洲地区的表现已得到充分证明：本研究分析了来自上海医疗记录大数据平台和传染病监测系统的数据。我们模拟了一次筛查，并绘制了接收器操作特征曲线（ROC），得出最佳临界值为 11.115mg/L，灵敏度和特异度分别为 0.784 和 0.723：我们在上海利用 CRP 检测法对艾滋病病毒感染者（PLHIV）进行结核病筛查的前景看好。我们的研究为后续研究提供了一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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中国疾病预防控制中心周报

CiteScore

5.90

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0.00%

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