{"title":"Saving KLF2/4 from γ-protocadherin to reduce vascular inflammation and atherosclerosis","authors":"Christian Park, Kyung In Baek, Hanjoong Jo","doi":"10.1038/s44161-024-00523-y","DOIUrl":null,"url":null,"abstract":"Atherosclerosis occurs in arterial regions exposed to disturbed flow, where endothelial expression of flow-sensitive, atheroprotective genes such as KLF2 and KLF4 is reduced. Protecting the endothelial expression of KLF2 and KLF4 from inhibitory factors could be a therapeutic approach to prevent vascular inflammation and atherosclerosis.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 9","pages":"1021-1023"},"PeriodicalIF":9.4000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00523-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Atherosclerosis occurs in arterial regions exposed to disturbed flow, where endothelial expression of flow-sensitive, atheroprotective genes such as KLF2 and KLF4 is reduced. Protecting the endothelial expression of KLF2 and KLF4 from inhibitory factors could be a therapeutic approach to prevent vascular inflammation and atherosclerosis.
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