New induction chemotherapy using intra-arterial infusion for tongue squamous cell carcinoma to avoid reconstructive surgery: A 6 case reports.

National journal of maxillofacial surgery Pub Date : 2024-05-01 Epub Date: 2024-07-24 DOI:10.4103/njms.njms_14_24
Tetsuharu Kaneko, Chihiro Kanno, Morio Yamazaki, Sadanoshin Yaginuma
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Abstract

Most tongue squamous cell carcinoma (TSCC) classified as T3 require reconstructive surgery, which inevitably causes problems with oral functions. We propose new induction chemotherapy using intra-arterial infusion for TSCC classified as T3 to avoid reconstructive surgery. This chemotherapy regimen consists of intra-arterial infusion of docetaxel and cisplatin and systemic administration of 5-fluorouracil. As a result of this treatment, the therapeutic effect was a complete response in five patients and a partial response in one patient, and the overall response rate was 100%. All six patients underwent partial resection because their tumors shrank with this induction chemotherapy. In addition, adverse events of grade 3 or more did not occur in all six patients. The median follow-up duration for all patients was 34 months, and they are alive. This intra-arterial chemotherapy regimen was shown to be highly efficacious and safe.

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采用动脉内输注的新诱导化疗治疗舌鳞状细胞癌,以避免重建手术:6例报告。
大多数 T3 级舌鳞状细胞癌(TSCC)需要进行整形手术,这不可避免地会对口腔功能造成影响。我们提出了一种新的诱导化疗方案,采用动脉内灌注的方式治疗 T3 级 TSCC,以避免重建手术。这种化疗方案包括多西他赛和顺铂的动脉内输注以及 5-氟尿嘧啶的全身给药。治疗结果是,5 名患者完全应答,1 名患者部分应答,总应答率为 100%。所有六名患者都接受了部分切除术,因为他们的肿瘤在诱导化疗后缩小了。此外,所有六名患者均未出现 3 级或以上不良反应。所有患者的中位随访时间为 34 个月,目前均健在。该动脉内化疗方案疗效显著,安全性高。
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