Khaoula Laazouzi , Nícollas Gonçalves Cavedini , Omaima Essaad Belhaj , Maryam Hadouachi , Hamid Boukhal , El mahjoub Chakir , Cristina Maria Moriguchi Jeckel , Ana Maria Marques da Silva , Maikol Salas-Ramirez
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引用次数: 0
Abstract
Animal models are essential in the development of new radiopharmaceuticals in nuclear medicine, particularly for accurate dose calculation in small animal internal dosimetry. This study presents a comprehensive dataset of S-values for eleven commonly used radionuclides, calculated using the DM_Bra mouse phantom with the GATE Monte Carlo simulation code. To validate our approach, we first compared S-values obtained from the DM_Bra phantom with published values derived from the Digimouse phantom using a Tc-99 m source. The differences between the two phantoms range from 0.68% to 12.45% for self-irradiation and from 0.15% to 4.19% for cross-irradiation when the source is the stomach. These results demonstrate good agreement with reference data, supporting the reliability of our dataset. We then expanded our analysis by generating S-values for additional radionuclides, reflecting their usage in both diagnostic and therapeutic applications. Furthermore, to assess the impact of varying mouse geometries on S-values, the DM_Bra phantom (26.9 g) was rescaled to represent two other mouse sizes (19.6 g and 35.9 g). The statistical uncertainty associated with all these S-values remains below 2%. This study offers a valuable resource for internal dosimetry in mice, providing detailed S-values for a wide range of radionuclides and organ geometries, which can be used in small animal PET and SPECT studies.
期刊介绍：
The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal.
Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.
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