N Navaneetha, Anandarao Munakala, Rambabu Chegondi
{"title":"Ag(I)-catalyzed diastereoselective oxidative cyclopropanation of prochiral alkyne-tethered 1,3-dicarbonitriles.","authors":"N Navaneetha, Anandarao Munakala, Rambabu Chegondi","doi":"10.1039/d4cc03697b","DOIUrl":null,"url":null,"abstract":"<p><p>Herein, we developed a highly diastereoselective silver-catalyzed intramolecular cyclopropanation of prochiral alkyne-tethered 1,3-dicarbonitriles using perchloric acid as an effective oxidizing agent. This method facilitates the construction of densely functionalized complex [6.6.5.3] frameworks having three all-carbon quaternary stereocenters in high yields. The significance of the reaction was demonstrated by a gram-scale reaction and post-synthetic modifications of the product.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc03697b","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, we developed a highly diastereoselective silver-catalyzed intramolecular cyclopropanation of prochiral alkyne-tethered 1,3-dicarbonitriles using perchloric acid as an effective oxidizing agent. This method facilitates the construction of densely functionalized complex [6.6.5.3] frameworks having three all-carbon quaternary stereocenters in high yields. The significance of the reaction was demonstrated by a gram-scale reaction and post-synthetic modifications of the product.
期刊介绍：
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
