Thiocarboxylic acid ligands combined with an adamantane framework provide strong passivation, enhancing the thermal, water, and long-term stability of perovskite nanocrystals. These ligands improved the film morphology, strengthened the interparticle interactions, and significantly boosted the LED performance, demonstrating the synergistic advantages of robust surface binding and molecular design.
{"title":"Thiocarboxylic Acids for Robust Passivation and Advanced Applications of Perovskite Nanocrystals","authors":"Taisei Kimura, Seung Jae Jeong, Yeonji Son, Sieun Yoon, Takuro Iizuka, Takashi Nagata, Yuta Ito, Hobeom Kim, Dong Ryeol Whang, Akito Masuhara","doi":"10.1039/d5cc07280h","DOIUrl":"https://doi.org/10.1039/d5cc07280h","url":null,"abstract":"Thiocarboxylic acid ligands combined with an adamantane framework provide strong passivation, enhancing the thermal, water, and long-term stability of perovskite nanocrystals. These ligands improved the film morphology, strengthened the interparticle interactions, and significantly boosted the LED performance, demonstrating the synergistic advantages of robust surface binding and molecular design.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"59 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anup Kumar Pradhan, Bhushan K Nandre, Pandiyan Sivasakthi, Sayan Halder, Sasanka Dalapati, Asim Bhaumik, Pralok K. Samanta, Chanchal Chakraborty
Two low-bandgap, metal-free donor–acceptor COFs (BTTh-TZ-COF and TPA-TZ-COF) are synthesized to compare bifunctional OER/ORR activities. The N and S-containing BTTh-TZ-COF exhibits superior charge transport, active sites, and lower energy barriers, leading to enhanced electrocatalysis and superior solid-state ZAB performance in terms of capacity and energy density.
{"title":"Heteroatoms Constructed Covalent Organic Frameworks for Oxygen Electrocatalysis and Rechargeable Zinc-Air Battery","authors":"Anup Kumar Pradhan, Bhushan K Nandre, Pandiyan Sivasakthi, Sayan Halder, Sasanka Dalapati, Asim Bhaumik, Pralok K. Samanta, Chanchal Chakraborty","doi":"10.1039/d5cc06145h","DOIUrl":"https://doi.org/10.1039/d5cc06145h","url":null,"abstract":"Two low-bandgap, metal-free donor–acceptor COFs (BTTh-TZ-COF and TPA-TZ-COF) are synthesized to compare bifunctional OER/ORR activities. The N and S-containing BTTh-TZ-COF exhibits superior charge transport, active sites, and lower energy barriers, leading to enhanced electrocatalysis and superior solid-state ZAB performance in terms of capacity and energy density.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"90 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
While photodynamic therapy (PDT) shows promise for tumor treatment, its efficacy is often constrained by the immunosuppressive tumor microenvironment. Pyroptosis, a Gasdermin-mediated inflammatory programmed cell death, augments PDT by releasing inflammatory cytokines and damage-associated molecular patterns that trigger robust antitumor immunity. This review systematically outlines the fundamental principles of PDT and critically analyzes existing immunological limitations in tumor treatment, highlighting the immunostimulatory mechanisms of pyroptosis in overcoming these specific therapeutic barriers. In addition, we summarize the rational design principles and recent advances in organelle-targeted photosensitizers—including those targeted to the plasma membrane, mitochondria, lysosomes, Golgi apparatus, and endoplasmic reticulum—for the effective induction of pyroptosis. We further discuss the persisting challenges associated with employing organelle-targeted photosensitizer-induced pyroptosis in tumor therapy. This review provides a strategic framework and future perspectives for developing next-generation precision photo-immunotherapies that harness pyroptosis–PDT synergy.
{"title":"Advances in organelle-targeted photosensitizer-mediated pyroptosis for photodynamic tumor therapy: overcoming immunological limitations","authors":"Jianlei Xie, Yu Xiao, Baoxin Peng, Xiasang Chen, Xinyin Zhang, Diqi Chen, Lijuan Song, Meiqian Xu, Wenjing Liao, Xiaowen Zhang","doi":"10.1039/d5cc06431g","DOIUrl":"https://doi.org/10.1039/d5cc06431g","url":null,"abstract":"While photodynamic therapy (PDT) shows promise for tumor treatment, its efficacy is often constrained by the immunosuppressive tumor microenvironment. Pyroptosis, a Gasdermin-mediated inflammatory programmed cell death, augments PDT by releasing inflammatory cytokines and damage-associated molecular patterns that trigger robust antitumor immunity. This review systematically outlines the fundamental principles of PDT and critically analyzes existing immunological limitations in tumor treatment, highlighting the immunostimulatory mechanisms of pyroptosis in overcoming these specific therapeutic barriers. In addition, we summarize the rational design principles and recent advances in organelle-targeted photosensitizers—including those targeted to the plasma membrane, mitochondria, lysosomes, Golgi apparatus, and endoplasmic reticulum—for the effective induction of pyroptosis. We further discuss the persisting challenges associated with employing organelle-targeted photosensitizer-induced pyroptosis in tumor therapy. This review provides a strategic framework and future perspectives for developing next-generation precision photo-immunotherapies that harness pyroptosis–PDT synergy.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"133 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexis Gillette, Annabel Lyon, Stanislav Savvin, Ines Puente Orench, Sepideh Rahimisheikh, Joke Hadermann, Magali Gimeno, Michael L. Neidig, Simon J Clarke
The crystal and magnetic structures of Sr3Fe4O6S2 (= Sr3Fe2O5Fe2OS2) and Sr4Fe4O7S2 (= Sr4Fe2O6Fe2OS2), designed using a building-block approach, are reported. They are fully charge-ordered with Fe2+ and Fe3+ ions in distinct layers showing independent long-range magnetic order. Complex microstructures in some regions suggest new targets.
{"title":"Structure and magnetism of mixed-valent iron oxysulfides Sr3Fe4O6S2 (Sr3(Fe3+)2O5(Fe2+)2OS2) and Sr4Fe4O7S2 (Sr4(Fe3+)2O6(Fe2+)2OS2)","authors":"Alexis Gillette, Annabel Lyon, Stanislav Savvin, Ines Puente Orench, Sepideh Rahimisheikh, Joke Hadermann, Magali Gimeno, Michael L. Neidig, Simon J Clarke","doi":"10.1039/d6cc00150e","DOIUrl":"https://doi.org/10.1039/d6cc00150e","url":null,"abstract":"The crystal and magnetic structures of Sr3Fe4O6S2 (= Sr3Fe2O5Fe2OS2) and Sr4Fe4O7S2 (= Sr4Fe2O6Fe2OS2), designed using a building-block approach, are reported. They are fully charge-ordered with Fe2+ and Fe3+ ions in distinct layers showing independent long-range magnetic order. Complex microstructures in some regions suggest new targets.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"247 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Redox-active ligands can play an important role in the chemistry of actinide complexes by facilitating alternative redox reaction pathways or modifying electronic properties. In this regard, we report here the synthesis of the first trinuclear uranyl complex of a bridging ligand radical, [K(18-c-6)][(UO2Cl2)3(TPymT)] 4.25THF (1). Structural and electronic characterisation reveals delocalisation of the radical across the bridging ligand and that the stability of the complex is entirely dependent on radical formation, with oxidation resulting in uranyl decomplexation. This study highlights the interplay between radical chemistry and actinide complexes and opens up new avenues for further research in this area.
{"title":"Stabilisation and characterisation of a trinuclear uranyl complex by ligand-radical formation","authors":"Mukesh Singh, Stephen Sproules, Jason Love","doi":"10.1039/d5cc06420a","DOIUrl":"https://doi.org/10.1039/d5cc06420a","url":null,"abstract":"Redox-active ligands can play an important role in the chemistry of actinide complexes by facilitating alternative redox reaction pathways or modifying electronic properties. In this regard, we report here the synthesis of the first trinuclear uranyl complex of a bridging ligand radical, [K(18-c-6)][(UO2Cl2)3(TPymT)] 4.25THF (1). Structural and electronic characterisation reveals delocalisation of the radical across the bridging ligand and that the stability of the complex is entirely dependent on radical formation, with oxidation resulting in uranyl decomplexation. This study highlights the interplay between radical chemistry and actinide complexes and opens up new avenues for further research in this area.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"5 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yinyu Jiang, Qi Du, Fengzhuo Wu, Wei Zhang, Yuan Ma, Zhuojia Xu, Zhonghua Li, Wenjing Ma, Tiehai Li
O-Glycosylation is a key modulator of CD34 biofunction. To investigate the distinct roles of different glycoform modifications, we report an efficient chemoenzymatic strategy to rapidly assemble a library of CD34 O-glycopeptides bearing sulfated and sialylated glycan variants, enabling the elucidation of how specific glycan modifications govern molecular recognition events.
{"title":"Chemoenzymatic synthesis of sulfated O-glycopeptides from human CD34","authors":"Yinyu Jiang, Qi Du, Fengzhuo Wu, Wei Zhang, Yuan Ma, Zhuojia Xu, Zhonghua Li, Wenjing Ma, Tiehai Li","doi":"10.1039/d6cc00114a","DOIUrl":"https://doi.org/10.1039/d6cc00114a","url":null,"abstract":"O-Glycosylation is a key modulator of CD34 biofunction. To investigate the distinct roles of different glycoform modifications, we report an efficient chemoenzymatic strategy to rapidly assemble a library of CD34 O-glycopeptides bearing sulfated and sialylated glycan variants, enabling the elucidation of how specific glycan modifications govern molecular recognition events.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"1 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stable oil-in-dispersion emulsions are achieved at ultralow additive levels (0.006 wt% EG-NPs and 0.03 mM SDS) through a same-charge cooperative mechanism between anionic SDS and negatively charged EG-NPs. Electrostatic repulsion ensures stability, enabling reversible control and broad oil compatibility, thereby offering a sustainable, low-concentration, and environmentally benign emulsification strategy.
{"title":"Oil-in-dispersion emulsions stabilized by electrostatic repulsions between surfactant and tea polyphenol nanoparticles.","authors":"Tingting Yan, Shaoying Fan, Yiping Yun, Zhenqi Jiang, Ming Liu, Lulu Zhou","doi":"10.1039/d5cc06060e","DOIUrl":"https://doi.org/10.1039/d5cc06060e","url":null,"abstract":"<p><p>Stable oil-in-dispersion emulsions are achieved at ultralow additive levels (0.006 wt% EG-NPs and 0.03 mM SDS) through a same-charge cooperative mechanism between anionic SDS and negatively charged EG-NPs. Electrostatic repulsion ensures stability, enabling reversible control and broad oil compatibility, thereby offering a sustainable, low-concentration, and environmentally benign emulsification strategy.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report two lanthanide clusters [Ln6F13 (12-crown-4)6]I3F2 (Ln=Ho, Er) synthesized through facile one-pot reactions of LnI3, 12-crown-4 and AgBF4 in a 1:2:1 ratio at room temperature. Both complexes represent rare examples of highly symmetrical fluoride-bridged lanthanide clusters encapsulating a fluoride ion.
{"title":"Synthesisof crown ether-capped highly symmetrical fluoridecentered lanthanide clusters [Ln6F13(12-crown-4)6]I3F2 (Ln = Ho, Er)","authors":"Yangjuan Li, Miao He, Yu Gong","doi":"10.1039/d6cc00045b","DOIUrl":"https://doi.org/10.1039/d6cc00045b","url":null,"abstract":"We report two lanthanide clusters [Ln6F13 (12-crown-4)6]I3F2 (Ln=Ho, Er) synthesized through facile one-pot reactions of LnI3, 12-crown-4 and AgBF4 in a 1:2:1 ratio at room temperature. Both complexes represent rare examples of highly symmetrical fluoride-bridged lanthanide clusters encapsulating a fluoride ion.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"30 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiyang Cui, Honghao Sun, Jingrong Jin, Yi Tang, Bo Wang, Leijie Zhou, Bing Zheng, Li Zheng, Hongchao Guo
Yne-enones are valuable platform molecules that undergo diverse transformations under both metal-catalyzed and metal-free conditions. However, their participation in phosphine-catalyzed annulation reactions has remained relatively unexplored. Herein, a phosphine-catalyzed tandem [2 + 4] annulation/detosylative aromatization of yne-enones with o-sulfonamidobenzaldehydes is reported, affording polyfunctionalized quinolines in moderate to high yields with a broad substrate scope. A plausible reaction mechanism is proposed, highlighting the potential of yne-enones to serve as versatile synthons for the development of new annulation strategies under phosphine catalysis.
{"title":"Tandem [2 + 4] Annulation/Aromatization Reaction of Yne-Enones with o-Sulfonamidobenzaldehydes","authors":"Zhiyang Cui, Honghao Sun, Jingrong Jin, Yi Tang, Bo Wang, Leijie Zhou, Bing Zheng, Li Zheng, Hongchao Guo","doi":"10.1039/d5cc06758h","DOIUrl":"https://doi.org/10.1039/d5cc06758h","url":null,"abstract":"Yne-enones are valuable platform molecules that undergo diverse transformations under both metal-catalyzed and metal-free conditions. However, their participation in phosphine-catalyzed annulation reactions has remained relatively unexplored. Herein, a phosphine-catalyzed tandem [2 + 4] annulation/detosylative aromatization of yne-enones with o-sulfonamidobenzaldehydes is reported, affording polyfunctionalized quinolines in moderate to high yields with a broad substrate scope. A plausible reaction mechanism is proposed, highlighting the potential of yne-enones to serve as versatile synthons for the development of new annulation strategies under phosphine catalysis.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"37 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liya Ma, Dongfang Ji, Wenmin Xie, Shanshan Li, Jingcheng Hao, Zhonghao Li
We present a CoO-NiO heterostructure nanosheet as an efficient electrocatalyst for the oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA). The catalyst achieves 100% HMF conversion, 98.7% FDCA yield, and 98.5% Faradaic efficiency, with density functional theory (DFT) calculations revealing interfacial electron redistribution for enhanced performance.
{"title":"CoO–NiO heterostructure nanosheets-enabled efficient electrooxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid","authors":"Liya Ma, Dongfang Ji, Wenmin Xie, Shanshan Li, Jingcheng Hao, Zhonghao Li","doi":"10.1039/d5cc06733b","DOIUrl":"https://doi.org/10.1039/d5cc06733b","url":null,"abstract":"We present a CoO-NiO heterostructure nanosheet as an efficient electrocatalyst for the oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA). The catalyst achieves 100% HMF conversion, 98.7% FDCA yield, and 98.5% Faradaic efficiency, with density functional theory (DFT) calculations revealing interfacial electron redistribution for enhanced performance.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"74 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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