Recent trends in hospital admission due to bipolar disorder in 10–19-year-olds in Spain: A nationwide population-based study

IF 5 2区医学 Q1 CLINICAL NEUROLOGY Bipolar Disorders Pub Date : 2024-09-05 DOI:10.1111/bdi.13500

Teresa López-Cuadrado, Ezra Susser, Gonzalo Martínez-Alés

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Abstract

Introduction

Bipolar disorder (BD) hospitalization rates in children and adolescents vary greatly across place and over time. There are no population-based studies on youth BD hospitalizations in Spain.

Methods

We identified all patients aged 10–19 hospitalized due to BD in Spain between 2000 and 2021, examined their demographic and clinical characteristics, and assessed temporal trends in hospitalizations – overall and stratified by age and presence of additional psychiatric comorbidity. We used Joinpoint regressions to identify inflection points and quantify whole-period and annual percentage changes (APCs) in trends.

Results

Of 4770 BD hospitalizations in 10–19-year-olds between 2000 and 2021 (average annual rate: 4.8 per 100,000), over half indicated an additional psychiatric comorbidity, most frequently substance abuse (62.2%), mostly due to cannabis (72.4%). During the study period, admissions increased twofold with an inflection point: Rates increased annually only between 2000 and 2008, for APCs 34.0% (95% confidence interval: 20.0%, 71.1%) among 10–14-year-olds, 10.3% (6.4%, 14.3%) among 15–19-year-olds, and 15.5% (11.5%, 22.7%) among patients with additional psychiatric comorbidity. Between 2009 and 2021, rates decreased moderately among 10–14-year-olds – APC: −8.3% (−14.1%, −4.4%) and slightly among 15–19-year-olds without additional psychiatric comorbidity – APC: −2.6(−5.7, −1.0), remaining largely stable among 15–19-year-olds overall.

Conclusions

Recent trends in hospitalization due to BD in 10–19-year-olds in Spain indicate salient increases in the early 2000s – especially among (i) patients aged 10–14 (decreasing moderately after 2009 among 10–14-year-olds and plateauing among 15–19-year-olds) and (ii) patients with additional psychiatric comorbidity (i.e., cannabis use disorder). These findings suggest links with recent changes in clinical practices for children and recent trends in substance use among Spanish youth.

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西班牙 10-19 岁儿童因躁郁症入院的最新趋势：一项基于全国人口的研究。

导言：躁郁症（BD）在儿童和青少年中的住院率因地区和时间的不同而有很大差异。目前还没有关于西班牙青少年躁郁症住院率的人群研究：我们确定了 2000 年至 2021 年期间西班牙所有因躁狂症住院的 10-19 岁患者，研究了他们的人口统计学和临床特征，并评估了住院治疗的时间趋势--总体趋势以及根据年龄和是否存在其他精神疾病合并症进行的分层趋势。我们使用联结点回归来确定拐点，并量化趋势的全周期和年度百分比变化（APCs）：2000 年至 2021 年间，在 4770 例 10-19 岁的 BD 住院病例中（年平均发病率：每 10 万人中有 4.8 例），超过一半的病例显示有额外的精神疾病合并症，其中最常见的是药物滥用（62.2%），大部分是由于大麻（72.4%）。在研究期间，入院人数增加了两倍，并出现了一个拐点：仅在 2000 年至 2008 年期间，入院率逐年上升，10-14 岁儿童的入院率为 34.0%（95% 置信区间：20.0%, 71.1%），15-19 岁儿童的入院率为 10.3%（6.4%, 14.3%），合并其他精神疾病的患者的入院率为 15.5%（11.5%, 22.7%）。2009年至2021年期间，10-14岁人群的发病率略有下降--APC：-8.3%（-14.1%，-4.4%），15-19岁无其他精神疾病合并症的人群的发病率略有下降--APC：-2.6（-5.7，-1.0），15-19岁人群的发病率总体上基本保持稳定：西班牙 10-19 岁儿童因 BD 住院治疗的最新趋势表明，2000 年代初，BD 住院治疗人数明显增加，尤其是在以下人群中：(i) 10-14 岁的患者（2009 年后，10-14 岁的患者人数适度减少，15-19 岁的患者人数趋于平稳）；(ii) 有其他精神疾病合并症（即大麻使用障碍）的患者。这些研究结果表明，儿童临床实践的最新变化与西班牙青少年使用药物的最新趋势有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.