Bipolar Disorders最新文献

Background: This was a 4-year mirror-image study of adult patients diagnosed with bipolar disorder (BD) assessing the effects on treatment continuation and hospitalisation between aripiprazole 1-month (A1M), risperidone-LAI (R-LAI) and the monthly and 3-monthly formulations of paliperidone palmitate (PP1M, PP3M). We aimed to evaluate and compare the use of A1M, R-LAI, and the monthly and 3-monthly formulations of paliperidone palmitate (PP1M, PP3M) by using the change of number and length of hospitalisations 2 years before compared to 2 years after initiation of LAIs for continuers and discontinuers. Secondary outcomes were: (1) discontinuation rates at 2 years and reasons per LAI, (2) time to discontinuation per LAI, and (3) time to first hospitalisation per LAI.

Results: A total of 122 BD were included; 74 continued LAI treatment at two years. Reasons for discontinuation were poor compliance (50%), ineffectiveness (43.2%), and tolerability issues (13.6%). Both time to individual LAI discontinuation and time to first hospital admission were significantly lower in the R-LAI group. There was a significant overall reduction in the number and length of hospitalisations two years before and after LAI initiation, although multivariate logistic regression analysis showed that A1M, PP1M and R-LAI were associated with an increased risk (OR = 1.89, 95% CI = 1.54-3.68, p = 0.015; OR = 1.63, 95% CI = 1.29-2.77, p = 0.022; OR = 3.08, 95% CI = 1.48-6.05, p = 0.008, respectively) of bed usage compared to PP3M. Last, study completers showed a considerable drop of 79% in number of hospital admissions and 83% in bed days (p = 0.001) as opposed to non-completers.

Conclusions: Study findings suggest that long-acting antipsychotics such as A1M, PP1M, and particularly PP3M are associated with high retention and lower hospitalisation rates after 2 years of treatment in patients with BD.

Background: Bipolar disorder is a severe mental disorder affecting millions worldwide, necessitating comprehensive policies and interventions.

Aims: To provide assessment of global inequalities in the burden of bipolar disorder and their projected trajectories to 2050.

Methods: Global Burden of Disease 2021 data from 204 countries and territories were analyzed, stratified by age, gender, and Socio-demographic Index (SDI) quintiles. Age-standardized prevalence (ASPR), incidence (ASIR), and years lived with disability (ASR YLD) per 100,000 population were calculated. Inequalities were assessed using the slope index of inequality (SII) and concentration index (CI), and ARIMA models were applied to project trends to 2050.

Results: From 1990 to 2021, global incidence of BD increased, while prevalence and years lived with disability (YLDs) remained relatively stable (ASPR: 453.7 [95% UI: 381.6-540.8] to 454.6 [95% UI: 377.9-545.8]). Females consistently had higher prevalence than males (474.2 vs. 435.0 per 100,000 in 2021). High-SDI regions reported the highest rates, with Australasia reaching 1110.8 (95% UI: 940.3-1305.9). The SII for incidence rose slightly (10.87-11.38), while the CI declined (0.096-0.012), indicating increasing absolute but decreasing relative inequalities. Projections suggest a rising global burden, with female prevalence remaining higher and incidence rates converging between genders (global ASIR: 33.8 per 100,000).

Conclusion: Global inequalities in bipolar disorder persist, disproportionately affecting females and high-SDI regions. Projected trends indicate an increasing burden with a narrowing gender gap in incidence, emphasizing the need for targeted interventions and further research on long-term impacts, including the effects of COVID-19.

Sacha Koutsikas, Antoine Yrondi, Laura Hatchondo, Rachel Debs. Back to the Future: May Kleine-Levin Syndrome be an Emerging Psychiatric Disorder? 26(6), 617–619. https://doi.org/10.1111/bdi.13455.

Description of error.

In the originally published article, the email address of corresponding author “Sacha Koutsikas” is [email protected] which he wants to change to [email protected].