The University of North Carolina Cancer Survivorship Cohort: A resource for collaborative survivorship research.

IF 3.7 3区 医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-09-06 DOI:10.1158/1055-9965.EPI-24-0794
Chelsea Anderson, Jeannette T Bensen, Emma H Allott, Patricia V Basta, Debra E Irwin, Adrian Gerstel, Laura Farnan, Hung-Jui Tan, Erin E Kent, Tzy-Mey Kuo, Christopher D Baggett, Andrew F Olshan, H Shelton Earp, Hazel B Nichols
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Abstract

Background: Rapid growth in the number of U.S. cancer survivors drives the need for ongoing research efforts to improve outcomes and experiences after cancer. Here we describe the University of North Carolina (UNC) Cancer Survivorship Cohort, a medical center-based cohort of adults with cancer that integrates medical record-abstracted cancer information, patient-reported outcomes, and biologic specimens.

Methods: Participants ages 18+ were recruited from UNC oncology clinics between April 2010 and August 2016. After enrollment, participants completed questionnaires on a range of topics including demographics, health history, health care access and utilization, quality of life, and symptoms. Blood samples and tumor tissue specimens were collected and processed by study staff, and cancer characteristics and other clinical data were abstracted from electronic medical records. Participants consented to recontact for future studies and linkage of their data with other data resources.

Results: In total, 3,999 participants with a cancer diagnosis were enrolled in the cohort. The most common cancer types among those enrolled included breast (N=866), uterine (N=458), colorectal (N=300), prostate (N=296), and head and neck (N=248). Blood specimens were collected for 3,027 (76%). Additional participants without cancer (N=1,299) were also enrolled, and the majority (62%) provided biospecimen samples.

Conclusions: We encourage wide collaboration with investigators across institutions seeking to advance research in cancer survivorship. Procedures are in place to support proposals for use of existing or linked data and for proposals that require participant recontact or analysis of biospecimens.

Impact: The UNC Cancer Survivorship Cohort is a unique resource for cancer survivorship research.

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北卡罗来纳大学癌症幸存者队列:幸存者合作研究资源。
背景:美国癌症幸存者人数的快速增长促使我们需要不断开展研究工作,以改善癌症的治疗效果和经历。我们在此介绍北卡罗来纳大学(UNC)癌症幸存者队列(Cancer Survivorship Cohort),这是一个以医疗中心为基础的成年癌症患者队列,整合了癌症病历摘要信息、患者报告的结果和生物标本:方法: 2010 年 4 月至 2016 年 8 月期间,从联合国大学肿瘤诊所招募了 18 岁以上的参与者。注册后,参与者填写了一系列主题的调查问卷,包括人口统计学、健康史、医疗保健的获取和利用、生活质量和症状。研究人员收集并处理血液样本和肿瘤组织标本,并从电子病历中摘录癌症特征和其他临床数据。参与者同意在今后的研究中与他们再次联系,并将他们的数据与其他数据资源联系起来:共有 3999 名确诊癌症的参与者加入了该群组。最常见的癌症类型包括乳腺癌(866 例)、子宫癌(458 例)、结直肠癌(300 例)、前列腺癌(296 例)以及头颈部癌症(248 例)。采集了 3027 人(76%)的血液标本。此外,还招募了其他未患癌症的参与者(1299 人),其中大多数(62%)提供了生物样本:我们鼓励与各机构的研究人员广泛合作,共同推进癌症幸存者研究。我们制定了相关程序,以支持使用现有数据或链接数据的提案,以及需要重新联系参与者或分析生物样本的提案:UNC 癌症幸存者队列是癌症幸存者研究的独特资源。
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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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