An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 associated with contaminated lettuce and the cascading risks from climate change, the United Kingdom, August to September 2022.

IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Eurosurveillance Pub Date : 2024-09-01 DOI:10.2807/1560-7917.ES.2024.29.36.2400161
Neil Cunningham, Claire Jenkins, Sarah Williams, Joanna Garner, Bernd Eggen, Amy Douglas, Tina Potter, Anthony Wilson, Giovanni Leonardi, Lesley Larkin, Susan Hopkins
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Abstract

Shiga-toxin producing Escherichia coli (STEC) O157 is a food-borne pathogen which causes gastrointestinal illness in humans. Ruminants are considered the main reservoir of infection, and STEC exceedance has been associated with heavy rainfall. In September 2022, a large outbreak of STEC O157:H7 was identified in the United Kingdom (UK). A national-level investigation was undertaken to identify the source of the outbreak and inform risk mitigation strategies. Whole genome sequencing (WGS) was used to identify outbreak cases. Overall, 259 cases with illness onset dates between 5 August and 12 October 2022, were confirmed across the UK. Epidemiological investigations supported a UK grown, nationally distributed, short shelf-life food item as the source of the outbreak. Analytical epidemiology and food chain analysis suggested lettuce as the likely vehicle of infection. Food supply chain tracing identified Grower X as the likely implicated producer. Independent of the food chain investigations, a novel geospatial analysis triangulating meteorological, flood risk, animal density and land use data was developed, also identifying Grower X as the likely source. Novel geospatial analysis and One Health approaches are potential tools for upstream data analysis to predict and prevent contamination events before they occur and to support evidence generation in outbreak investigations.

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与受污染生菜有关的产志贺毒素大肠杆菌(STEC)O157:H7疫情和气候变化的连带风险,英国,2022年8月至9月。
产志贺毒素大肠埃希氏菌(STEC)O157 是一种食源性病原体,可导致人类肠胃疾病。反刍动物被认为是主要的感染源,STEC超标与暴雨有关。2022 年 9 月,英国爆发了大规模的 STEC O157:H7 疫情。为确定疫情来源并为降低风险战略提供信息,英国开展了国家级调查。全基因组测序 (WGS) 被用来确定疫情病例。英国全国共确诊 259 例病例,发病日期在 2022 年 8 月 5 日至 10 月 12 日之间。流行病学调查支持英国种植、全国销售、保质期短的食品为疫情源头。流行病学分析和食物链分析表明,莴苣可能是感染源。食品供应链追踪发现,种植者 X 可能是受牵连的生产者。在食物链调查之外,还开发了一种新的地理空间分析方法,将气象、洪水风险、动物密度和土地使用数据三角化,也确定 X 种植者可能是疫源地。新型地理空间分析和 "同一健康 "方法是上游数据分析的潜在工具,可在污染事件发生前进行预测和预防,并为疫情调查中的证据生成提供支持。
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来源期刊
Eurosurveillance
Eurosurveillance INFECTIOUS DISEASES-
CiteScore
32.70
自引率
2.10%
发文量
430
审稿时长
3-8 weeks
期刊介绍: Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.
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