首页 > 最新文献

Eurosurveillance最新文献

英文 中文
Author's response: Viral load decline time offers theoretical insight rather than practical value.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.9.2500155
Jakob Jonnerby, Ajit Lalvani
{"title":"Author's response: Viral load decline time offers theoretical insight rather than practical value.","authors":"Jakob Jonnerby, Ajit Lalvani","doi":"10.2807/1560-7917.ES.2025.30.9.2500155","DOIUrl":"10.2807/1560-7917.ES.2025.30.9.2500155","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 9","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health inequalities in incidence of bacteraemias: a national surveillance and data linkage study, England, 2018 to 2022.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.9.2400312
Andrea Mazzella, Zahin Amin-Chowdhury, Amelia Andrews, Andre Charlett, Colin S Brown, Russell Hope, Dimple Chudasama

BackgroundHealth inequalities exist globally, but limited data exist on this topic for bacteraemia.AimIn this study we investigated health inequalities surrounding bacteraemia in England, to identify high-risk population groups and areas of intervention.MethodsWe retrospectively analysed English surveillance data between 2018 and 2022 for Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, and both meticillin-sensitive and resistant Staphylococcus aureus (MSSA, MRSA) bacteraemia. Crude incidence rates stratified by index of multiple deprivation and ethnic groups were calculated; age-adjusted rate ratios were estimated using negative binomial regression models.ResultsWe identified 342,787 bacteraemia cases. Across all pathogens, as the level of deprivation rose, so did the age-adjusted bacteraemia incidence rate ratio. Compared with residents of the 20% least deprived areas of England, residents of the 20% most deprived areas had a 2.68-fold increased bacteraemia rate for MRSA (95% CI: 2.29-3.13) and 1.95-fold for E. coli (95% CI: 1.84-2.05), and 15% higher odds of dying within 30 days of any bacteraemia (95% CI: 1.13-1.19). After age adjustment, the incidence of all bacteraemia was higher in the Asian and Black groups compared with the White group: for MRSA, 79% higher in the Asian (95% CI: 1.51-2.10) and 59% higher in the Black (95% CI: 1.29-1.95) groups. The exception was MSSA, whose incidence was highest in the White group.ConclusionDisproportionately higher age-adjusted incidence of bacteraemia occurred in deprived areas and ethnic minorities. These disparities are likely multifactorial, possibly including socioeconomic, cultural, and systemic risk factors and different burden of comorbidities. Better understanding these factors can enable targeted interventions.

{"title":"Health inequalities in incidence of bacteraemias: a national surveillance and data linkage study, England, 2018 to 2022.","authors":"Andrea Mazzella, Zahin Amin-Chowdhury, Amelia Andrews, Andre Charlett, Colin S Brown, Russell Hope, Dimple Chudasama","doi":"10.2807/1560-7917.ES.2025.30.9.2400312","DOIUrl":"10.2807/1560-7917.ES.2025.30.9.2400312","url":null,"abstract":"<p><p>BackgroundHealth inequalities exist globally, but limited data exist on this topic for bacteraemia.AimIn this study we investigated health inequalities surrounding bacteraemia in England, to identify high-risk population groups and areas of intervention.MethodsWe retrospectively analysed English surveillance data between 2018 and 2022 for <i>Escherichia coli</i>, <i>Klebsiella</i> species, <i>Pseudomonas aeruginosa</i>, and both meticillin-sensitive and resistant <i>Staphylococcus aureus</i> (MSSA, MRSA) bacteraemia. Crude incidence rates stratified by index of multiple deprivation and ethnic groups were calculated; age-adjusted rate ratios were estimated using negative binomial regression models.ResultsWe identified 342,787 bacteraemia cases. Across all pathogens, as the level of deprivation rose, so did the age-adjusted bacteraemia incidence rate ratio. Compared with residents of the 20% least deprived areas of England, residents of the 20% most deprived areas had a 2.68-fold increased bacteraemia rate for MRSA (95% CI: 2.29-3.13) and 1.95-fold for <i>E. coli</i> (95% CI: 1.84-2.05), and 15% higher odds of dying within 30 days of any bacteraemia (95% CI: 1.13-1.19). After age adjustment, the incidence of all bacteraemia was higher in the Asian and Black groups compared with the White group: for MRSA, 79% higher in the Asian (95% CI: 1.51-2.10) and 59% higher in the Black (95% CI: 1.29-1.95) groups. The exception was MSSA, whose incidence was highest in the White group.ConclusionDisproportionately higher age-adjusted incidence of bacteraemia occurred in deprived areas and ethnic minorities. These disparities are likely multifactorial, possibly including socioeconomic, cultural, and systemic risk factors and different burden of comorbidities. Better understanding these factors can enable targeted interventions.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 9","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective case-case study investigation of a significant increase in Cryptosporidium spp. in England and Wales, August to September 2023.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.9.2400493
Sarah V Williams, Eve Matthews, Thomas Inns, Christopher Roberts, Joshua Matizanadzo, Paul Cleary, Richard Elson, Chris J Williams, Reece Jarratt, Rachel M Chalmers, Roberto Vivancos

BackgroundLaboratory surveillance detected an unprecedented increase in Cryptosporidium spp. (predominantly Cryptosporidium hominis) in England and Wales in August 2023. Cases are not routinely followed up in all of England and Wales, and initial investigations identified no common exposures.AimTo perform a retrospective case-case study investigation of the increase in Cryptosporidium spp. in England and Wales.MethodsWe conducted an unmatched case-case study with 203 cases of laboratory-confirmed C. hominis and 614 comparator cases of laboratory-confirmed Campylobacter spp. reported between 14 August and 30 September 2023. We fitted a multilevel logistic regression model, with random intercepts for geographical region, to estimate adjusted odds ratios (aOR) for exposures. We present the final model as aOR and 95% confidence intervals (CI).ResultsMultivariable analysis identified associations with swimming pool use (aOR: 5.3, 95% CI: 2.3-9.3), travel to Spain (aOR: 6.5, 95% CI: 3.5-12.3) and young age, with children 0-4 years having the strongest association of being a case (aOR: 3.6, 95% CI: 1.5-8.6). We also identified associations with swimming in a river, and travel to France or Türkiye, but there was low frequency of exposure among cases and comparator cases.ConclusionsFollowing the largest recorded increase of Cryptosporidium spp. and in particular C. hominis cases in England and Wales, we identified several exposures, suggesting that causation was likely to be multifactorial. We recommend development of a standardised questionnaire to enable rapid investigation of future case increases, which will improve existing surveillance and inform public health actions.

{"title":"Retrospective case-case study investigation of a significant increase in <i>Cryptosporidium</i> spp. in England and Wales, August to September 2023.","authors":"Sarah V Williams, Eve Matthews, Thomas Inns, Christopher Roberts, Joshua Matizanadzo, Paul Cleary, Richard Elson, Chris J Williams, Reece Jarratt, Rachel M Chalmers, Roberto Vivancos","doi":"10.2807/1560-7917.ES.2025.30.9.2400493","DOIUrl":"10.2807/1560-7917.ES.2025.30.9.2400493","url":null,"abstract":"<p><p>BackgroundLaboratory surveillance detected an unprecedented increase in <i>Cryptosporidium</i> spp. (predominantly <i>Cryptosporidium hominis</i>) in England and Wales in August 2023. Cases are not routinely followed up in all of England and Wales, and initial investigations identified no common exposures.AimTo perform a retrospective case-case study investigation of the increase in <i>Cryptosporidium</i> spp. in England and Wales.MethodsWe conducted an unmatched case-case study with 203 cases of laboratory-confirmed <i>C. hominis</i> and 614 comparator cases of laboratory-confirmed <i>Campylobacter</i> spp. reported between 14 August and 30 September 2023. We fitted a multilevel logistic regression model, with random intercepts for geographical region, to estimate adjusted odds ratios (aOR) for exposures. We present the final model as aOR and 95% confidence intervals (CI).ResultsMultivariable analysis identified associations with swimming pool use (aOR: 5.3, 95% CI: 2.3-9.3), travel to Spain (aOR: 6.5, 95% CI: 3.5-12.3) and young age, with children 0-4 years having the strongest association of being a case (aOR: 3.6, 95% CI: 1.5-8.6). We also identified associations with swimming in a river, and travel to France or Türkiye, but there was low frequency of exposure among cases and comparator cases.ConclusionsFollowing the largest recorded increase of <i>Cryptosporidium</i> spp. and in particular <i>C. hominis</i> cases in England and Wales, we identified several exposures, suggesting that causation was likely to be multifactorial. We recommend development of a standardised questionnaire to enable rapid investigation of future case increases, which will improve existing surveillance and inform public health actions.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 9","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: Viral load decline time offers theoretical insight rather than practical value.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.9.2500151
Nawfal R Hussein, Delovan S Mahfodh
{"title":"Letter to the editor: Viral load decline time offers theoretical insight rather than practical value.","authors":"Nawfal R Hussein, Delovan S Mahfodh","doi":"10.2807/1560-7917.ES.2025.30.9.2500151","DOIUrl":"10.2807/1560-7917.ES.2025.30.9.2500151","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 9","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of Staphylococcus haemolyticus nosocomial bacteraemia in neonatal intensive care units, France, 2019 to 2023: predominance of the ST29 (CC3) multidrug-resistant lineage.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.11.2400309
Patricia Martins Simões, Nathalie van der Mee-Marquet, Benjamin Youenou, Anne-Gaelle Ranc, Céline Dupieux-Chabert, Guillaume Menard, Clarisse Dupin, Marine Butin, François Vandenesch, Frédéric Laurent, Anne Berger-Carbonne, Camille Kolenda, Anne Tristan

BackgroundStaphylococcus haemolyticus (SH) is an opportunistic pathogen associated with nosocomial infections, particularly bacteraemia in neonates. Epidemiological trends and genetic diversity of these infections worldwide are largely unknown.AimTo investigate an increase in SH vascular catheter-related bacteraemia in neonates and describe the molecular epidemiology in France between 2019 and 2023.MethodsWe analysed clinical and microbiological surveillance data from the French national surveillance network for central catheter-related (venous and umbilical) infections between 2019 and 2023. We also performed genomic and phylogenetic analyses of 496 strains isolated both inside (n = 383 from neonates, staff and environmental samples) and outside (n = 113 from adults) the neonatal intensive care unit (NICU) settings.ResultsThe proportion of SH among the 474 reported cases of nosocomial bacteraemia increased from about 20% to 30% over 5 years, mainly affecting very low birth weight preterm neonates (≤ 1,500 g). The ST29 sequence type (ST) not prevalent in previous studies was predominant, accounting for 74% of NICU strains. ST29 was characterised by phenotypic multidrug resistance to at least six classes of antibiotics (oxacillin, quinolones, gentamicin, cotrimoxazole, clindamycin and rifampicin), which distinguished it with good sensitivity and specificity from other prevalent multidrug-resistant STs identified (ST1 and ST25). ST29 strains more frequently harboured the drfG, vga-LC and mupA genes and a triple point mutation (D471E, I527M and S532N) in the rpoB gene.ConclusionsThe present study highlights the success of a highly resistant ST29 lineage in French NICUs mainly affecting very low birth weight premature neonates.

{"title":"Epidemiology of <i>Staphylococcus haemolyticus</i> nosocomial bacteraemia in neonatal intensive care units, France, 2019 to 2023: predominance of the ST29 (CC3) multidrug-resistant lineage.","authors":"Patricia Martins Simões, Nathalie van der Mee-Marquet, Benjamin Youenou, Anne-Gaelle Ranc, Céline Dupieux-Chabert, Guillaume Menard, Clarisse Dupin, Marine Butin, François Vandenesch, Frédéric Laurent, Anne Berger-Carbonne, Camille Kolenda, Anne Tristan","doi":"10.2807/1560-7917.ES.2025.30.11.2400309","DOIUrl":"10.2807/1560-7917.ES.2025.30.11.2400309","url":null,"abstract":"<p><p>Background<i>Staphylococcus haemolyticus</i> (SH) is an opportunistic pathogen associated with nosocomial infections, particularly bacteraemia in neonates. Epidemiological trends and genetic diversity of these infections worldwide are largely unknown.AimTo investigate an increase in SH vascular catheter-related bacteraemia in neonates and describe the molecular epidemiology in France between 2019 and 2023.MethodsWe analysed clinical and microbiological surveillance data from the French national surveillance network for central catheter-related (venous and umbilical) infections between 2019 and 2023. We also performed genomic and phylogenetic analyses of 496 strains isolated both inside (n = 383 from neonates, staff and environmental samples) and outside (n = 113 from adults) the neonatal intensive care unit (NICU) settings.ResultsThe proportion of SH among the 474 reported cases of nosocomial bacteraemia increased from about 20% to 30% over 5 years, mainly affecting very low birth weight preterm neonates (≤ 1,500 g). The ST29 sequence type (ST) not prevalent in previous studies was predominant, accounting for 74% of NICU strains. ST29 was characterised by phenotypic multidrug resistance to at least six classes of antibiotics (oxacillin, quinolones, gentamicin, cotrimoxazole, clindamycin and rifampicin), which distinguished it with good sensitivity and specificity from other prevalent multidrug-resistant STs identified (ST1 and ST25). ST29 strains more frequently harboured the <i>drfG</i>, <i>vga-LC</i> and <i>mupA</i> genes and a triple point mutation (D471E, I527M and S532N) in the <i>rpoB</i> gene.ConclusionsThe present study highlights the success of a highly resistant ST29 lineage in French NICUs mainly affecting very low birth weight premature neonates.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 11","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global meta-analysis of short-term associations between ambient temperature and pathogen-specific respiratory infections, 2004 to 2023.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.11.2400375
Xue Shang, Ruhao Zhang, Junyao Zheng, Yi Luo, Kangle Guo, Qingqing Zhou, Xu Guang, Ning Zhang, Hao Xue, Haidong Wang, Chunfu Yang, Zhen Zhang, Bin Zhu

BackgroundAmbient temperature may affect respiratory health, while the temperature sensitivity of respiratory infections may be pathogen-dependent.AimsWe sought to explore pathogen-specific associations between ambient temperature and respiratory infections.MethodsWe searched nine databases for a random-effects meta-analysis to pool the relative risk (RR) of respiratory infection by pathogen per 1° C temperature rise, compared to populations unexposed to the same temperature. We conducted pathogen-specific analyses, sensitivity analyses, subgroup analyses and meta-regression.ResultsA total of 137 studies were eligible for meta-analysis. The pooled and single-study estimates revealed that the incidence of respiratory syncytial virus (RR = 0.14; 95% confidence interval (CI): 0.09-0.23), influenza virus (IV) (RR = 0.40; 95% CI: 0.27-0.61), human metapneumovirus (RR = 0.48; 95% CI: 0.32-0.73), human coronavirus (HCoV) (RR = 0.21; 95% CI: 0.07-0.61) and SARS-CoV-2 (RR = 0.52; 95% CI: 0.35-0.78) decreased per 1° C temperature rise, while that of human parainfluenza virus (HPIV) (RR = 2.35; 95% CI: 1.46-3.77), human bocavirus (HBoV) (RR = 1.86; 95% CI: 1.04-3.32) and MERS-CoV (RR = 1.05; 95% CI: 1.04-1.07) increased. The risk of infection was lower for IVA, IVB, HCoV-229E and HCoV-OC43, while HPIV-3, and HBoV-1 were at increased risk. The risk of Streptococcus pyogenes pharyngitis (RR = 0.46; 95% CI: 0.30-0.69) decreased per 1° C temperature rise, while Pseudomonas aeruginosa (RR = 1.04; 95% CI: 1.03-1.05) and Legionella pneumophila infections (RR = 2.69; 95% CI: 1.11-6.53) increased.ConclusionsTemperature sensitivity of respiratory infections can vary with the specific pathogen type and subtype that causes the infection. As the climatic conditions will become warmer, public health policy makers should act to develop pathogen adaptation strategies.

背景环境温度可能会影响呼吸道健康,而呼吸道感染对温度的敏感性可能取决于病原体。方法我们搜索了九个数据库,进行随机效应荟萃分析,将温度每升高 1°C 病原体引起呼吸道感染的相对风险 (RR) 与未暴露于相同温度的人群进行比较。我们进行了病原体特异性分析、敏感性分析、亚组分析和元回归分析。结果 共有 137 项研究符合元分析条件。汇总和单个研究的估计结果显示,呼吸道合胞病毒(RR = 0.14;95% 置信区间 (CI):0.09-0.23)、流感病毒(IV)(RR = 0.40;95% CI:0.27-0.61)、人类偏肺病毒(RR = 0.48;95% CI:0.32-0.73)、人类冠状病毒(HCoV)(RR = 0.21;95% CI:0.07-0.61)和 SARS-CoV-2 (RR = 0.52;95% CI:0.35-0.78)的感染风险每升高 1 摄氏度就会降低,而人类副流感病毒(HPIV)(RR = 2.35;95% CI:1.46-3.77)、人类波卡病毒(HBoV)(RR = 1.86;95% CI:1.04-3.32)和 MERS-CoV (RR = 1.05;95% CI:1.04-1.07)的感染风险则会升高。IVA、IVB、HCoV-229E 和 HCoV-OC43 的感染风险较低,而 HPIV-3 和 HBoV-1 的感染风险较高。气温每升高 1 摄氏度,化脓性链球菌咽炎(RR = 0.46;95% CI:0.30-0.69)的感染风险降低,而铜绿假单胞菌(RR = 1.04;95% CI:1.03-1.05)和嗜肺军团菌(RR = 2.69;95% CI:1.11-6.53)的感染风险增加。随着气候条件的变暖,公共卫生决策者应采取行动制定病原体适应策略。
{"title":"Global meta-analysis of short-term associations between ambient temperature and pathogen-specific respiratory infections, 2004 to 2023.","authors":"Xue Shang, Ruhao Zhang, Junyao Zheng, Yi Luo, Kangle Guo, Qingqing Zhou, Xu Guang, Ning Zhang, Hao Xue, Haidong Wang, Chunfu Yang, Zhen Zhang, Bin Zhu","doi":"10.2807/1560-7917.ES.2025.30.11.2400375","DOIUrl":"10.2807/1560-7917.ES.2025.30.11.2400375","url":null,"abstract":"<p><p>BackgroundAmbient temperature may affect respiratory health, while the temperature sensitivity of respiratory infections may be pathogen-dependent.AimsWe sought to explore pathogen-specific associations between ambient temperature and respiratory infections.MethodsWe searched nine databases for a random-effects meta-analysis to pool the relative risk (RR) of respiratory infection by pathogen per 1° C temperature rise, compared to populations unexposed to the same temperature. We conducted pathogen-specific analyses, sensitivity analyses, subgroup analyses and meta-regression.ResultsA total of 137 studies were eligible for meta-analysis. The pooled and single-study estimates revealed that the incidence of respiratory syncytial virus (RR = 0.14; 95% confidence interval (CI): 0.09-0.23), influenza virus (IV) (RR = 0.40; 95% CI: 0.27-0.61), human metapneumovirus (RR = 0.48; 95% CI: 0.32-0.73), human coronavirus (HCoV) (RR = 0.21; 95% CI: 0.07-0.61) and SARS-CoV-2 (RR = 0.52; 95% CI: 0.35-0.78) decreased per 1° C temperature rise, while that of human parainfluenza virus (HPIV) (RR = 2.35; 95% CI: 1.46-3.77), human bocavirus (HBoV) (RR = 1.86; 95% CI: 1.04-3.32) and MERS-CoV (RR = 1.05; 95% CI: 1.04-1.07) increased. The risk of infection was lower for IVA, IVB, HCoV-229E and HCoV-OC43, while HPIV-3, and HBoV-1 were at increased risk. The risk of <i>Streptococcus pyogenes</i> pharyngitis (RR = 0.46; 95% CI: 0.30-0.69) decreased per 1° C temperature rise, while <i>Pseudomonas aeruginosa</i> (RR = 1.04; 95% CI: 1.03-1.05) and <i>Legionella pneumophila</i> infections (RR = 2.69; 95% CI: 1.11-6.53) increased.ConclusionsTemperature sensitivity of respiratory infections can vary with the specific pathogen type and subtype that causes the infection. As the climatic conditions will become warmer, public health policy makers should act to develop pathogen adaptation strategies.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 11","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.10.2500131
Muhammad Ibaad Alvi, Merav Kliner, William Welfare, N Claire Gordon, Sherine Thomas, Simon Padfield, Hannah E Emmett, Ellen Heinsbroek, Gareth J Hughes, Natalie Groves, Eileen Gallagher, Steven Pullan, Amy Belfield, Catherine F Houlihan, Tommy Rampling, Geraldine O'Hara, Anne Tunbridge, Jake Dunning, Elizabeth Whittaker, Alejandra Alonso, Mike Beadsworth, Brendan Ai Payne, Meera Chand, Susan Hopkins, Gillian Armstrong

We report two importations of monkeypox virus clade Ib infection to the United Kingdom in 2024. The first was a traveller returning from Tanzania, Rwanda and Uganda, the second from Uganda. Both presented with fever and typical skin lesions; 147 contacts were followed up, 19 vaccinated with MVA-BN. Three household contacts of the first individual, including two children, became infected. These are the first reported autochthonous transmissions of clade Ib in Europe, and first paediatric cases outside the African continent.

{"title":"Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024.","authors":"Muhammad Ibaad Alvi, Merav Kliner, William Welfare, N Claire Gordon, Sherine Thomas, Simon Padfield, Hannah E Emmett, Ellen Heinsbroek, Gareth J Hughes, Natalie Groves, Eileen Gallagher, Steven Pullan, Amy Belfield, Catherine F Houlihan, Tommy Rampling, Geraldine O'Hara, Anne Tunbridge, Jake Dunning, Elizabeth Whittaker, Alejandra Alonso, Mike Beadsworth, Brendan Ai Payne, Meera Chand, Susan Hopkins, Gillian Armstrong","doi":"10.2807/1560-7917.ES.2025.30.10.2500131","DOIUrl":"10.2807/1560-7917.ES.2025.30.10.2500131","url":null,"abstract":"<p><p>We report two importations of monkeypox virus clade Ib infection to the United Kingdom in 2024. The first was a traveller returning from Tanzania, Rwanda and Uganda, the second from Uganda. Both presented with fever and typical skin lesions; 147 contacts were followed up, 19 vaccinated with MVA-BN. Three household contacts of the first individual, including two children, became infected. These are the first reported autochthonous transmissions of clade Ib in Europe, and first paediatric cases outside the African continent.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 10","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of a cat infected with European bat lyssavirus type 1, the Netherlands, October 2024.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.10.2500154
Phaedra Eblé, Aldo Dekker, Sanne van den End, Vanessa Visser, Marc Engelsma, Frank Harders, Lucien van Keulen, Erik van Weezep, Melle Holwerda

In October 2024, an infection of European bat lyssavirus type 1 was confirmed in a domestic cat in the Netherlands. Several weeks before, the owners had found a dead bat considered to be caught by the cat. Nine persons exposed to the cat received post-exposure prophylaxis and four domestic animals from the same household were quarantined. This report stresses the need for vigilance for rabies in domestic animals in countries where lyssavirus infections in bats are endemic.

{"title":"A case report of a cat infected with European bat lyssavirus type 1, the Netherlands, October 2024.","authors":"Phaedra Eblé, Aldo Dekker, Sanne van den End, Vanessa Visser, Marc Engelsma, Frank Harders, Lucien van Keulen, Erik van Weezep, Melle Holwerda","doi":"10.2807/1560-7917.ES.2025.30.10.2500154","DOIUrl":"10.2807/1560-7917.ES.2025.30.10.2500154","url":null,"abstract":"<p><p>In October 2024, an infection of European bat lyssavirus type 1 was confirmed in a domestic cat in the Netherlands. Several weeks before, the owners had found a dead bat considered to be caught by the cat. Nine persons exposed to the cat received post-exposure prophylaxis and four domestic animals from the same household were quarantined. This report stresses the need for vigilance for rabies in domestic animals in countries where lyssavirus infections in bats are endemic.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 10","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of SARS-CoV-2 variant mutations on susceptibility to monoclonal antibodies and antiviral drugs: a non-systematic review, April 2022 to October 2024.
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.10.2400252
Maja Vukovikj, Angeliki Melidou, Priyanka Nannapaneni, Tanja Normark, Annette Kraus, Eeva K Broberg

BackgroundMonoclonal antibodies (mAbs) and antiviral drugs have emerged as additional tools for treatment of COVID-19.AimWe aimed to review data on susceptibility of 14 SARS-CoV-2 variants to mAbs and antiviral drugs authorised in the European Union/European Economic Area (EU/EEA) countries.MethodsWe constructed a literature review compiling 298 publications from four databases: PubMed, Science Direct, LitCovid and BioRxiv/MedRxiv preprint servers. We included publications on nirmatrelvir and ritonavir, remdesivir and tixagevimab and cilgavimab, regdanvimab, casirivimab and imdevimab, and sotrovimab approved by the European Medicines Agency (EMA) by 1 October 2024.ResultsThe mutations identified in the open reading frame (ORF)1ab, specifically nsp5:H172Y, nsp5:H172Y and Q189E, nsp5:L50F and E166V and nsp5:L50F, E166A and L167V, led to a decrease in susceptibility to nirmatrelvir and ritonavir, ranging from moderate (25-99) to high reductions (> 100). Casirivimab and imdevimab exhibited highly reduced neutralisation capacity across all Omicron sub-lineages. Sub-lineages BA.1, BA.2 and BA.5 had decreased susceptibility to regdanvimab, while sotrovimab showed decreased efficacy for BA.2, BA.4, BQ.1.1 and BA.2.86. Tixagevimab and cilgavimab exhibited highly reduced neutralisation activity against BQ.1, BQ.1.1, XBB, XBB.1.5 and BA.2.86 sub-lineages.ConclusionsThe emergence of new variants, some with altered antigenic characteristics, may lead to resistance against mAbs and/or antiviral drugs and evasion of immunity induced naturally or by vaccination. This summary of mutations, combination of mutations and SARS-CoV-2 variants linked to reduced susceptibility to mAbs and antiviral drugs, should aid the selection of appropriate treatment strategies and/or phasing out therapies that have lost their effectiveness.

{"title":"Impact of SARS-CoV-2 variant mutations on susceptibility to monoclonal antibodies and antiviral drugs: a non-systematic review, April 2022 to October 2024.","authors":"Maja Vukovikj, Angeliki Melidou, Priyanka Nannapaneni, Tanja Normark, Annette Kraus, Eeva K Broberg","doi":"10.2807/1560-7917.ES.2025.30.10.2400252","DOIUrl":"10.2807/1560-7917.ES.2025.30.10.2400252","url":null,"abstract":"<p><p>BackgroundMonoclonal antibodies (mAbs) and antiviral drugs have emerged as additional tools for treatment of COVID-19.AimWe aimed to review data on susceptibility of 14 SARS-CoV-2 variants to mAbs and antiviral drugs authorised in the European Union/European Economic Area (EU/EEA) countries.MethodsWe constructed a literature review compiling 298 publications from four databases: PubMed, Science Direct, LitCovid and BioRxiv/MedRxiv preprint servers. We included publications on nirmatrelvir and ritonavir, remdesivir and tixagevimab and cilgavimab, regdanvimab, casirivimab and imdevimab, and sotrovimab approved by the European Medicines Agency (EMA) by 1 October 2024.ResultsThe mutations identified in the open reading frame (ORF)1ab, specifically nsp5:H172Y, nsp5:H172Y and Q189E, nsp5:L50F and E166V and nsp5:L50F, E166A and L167V, led to a decrease in susceptibility to nirmatrelvir and ritonavir, ranging from moderate (25-99) to high reductions (> 100). Casirivimab and imdevimab exhibited highly reduced neutralisation capacity across all Omicron sub-lineages. Sub-lineages BA.1, BA.2 and BA.5 had decreased susceptibility to regdanvimab, while sotrovimab showed decreased efficacy for BA.2, BA.4, BQ.1.1 and BA.2.86. Tixagevimab and cilgavimab exhibited highly reduced neutralisation activity against BQ.1, BQ.1.1, XBB, XBB.1.5 and BA.2.86 sub-lineages.ConclusionsThe emergence of new variants, some with altered antigenic characteristics, may lead to resistance against mAbs and/or antiviral drugs and evasion of immunity induced naturally or by vaccination. This summary of mutations, combination of mutations and SARS-CoV-2 variants linked to reduced susceptibility to mAbs and antiviral drugs, should aid the selection of appropriate treatment strategies and/or phasing out therapies that have lost their effectiveness.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 10","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum for Euro Surveill. 2025;30(7).
IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2025-03-01 DOI: 10.2807/1560-7917.ES.2025.30.11.240320c
{"title":"Erratum for Euro Surveill. 2025;30(7).","authors":"","doi":"10.2807/1560-7917.ES.2025.30.11.240320c","DOIUrl":"10.2807/1560-7917.ES.2025.30.11.240320c","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 11","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Eurosurveillance
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1