{"title":"Profiling Metal-Induced Genotoxic Endpoints.","authors":"Mohammad Shoeb, Gregory M Zarus, Henry E Abadin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Many toxic metals are involved in the initiation and progression of DNA damage that can result in the activation of DNA damage response machinery at double- and single-stranded DNA; this response can result in global and gene-specific DNA alteration. The toxicological profiles from the Agency for Toxic Substances and Disease Registry (ATSDR) and several other studies have demonstrated the influence of metal exposure-induced genotoxic endpoints and epigenetic modifications. Our review systematically summarizes accumulating evidence from ATSDR toxicological profiles and the available literature that demonstrate a possible induction of various genotoxic endpoints and metal exposures. We include in this article studies on chromium, arsenic, nickel, lead, mercury, and zinc.</p>","PeriodicalId":15713,"journal":{"name":"Journal of Environmental Health","volume":"86 5","pages":"30-35"},"PeriodicalIF":0.8000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375607/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Environmental Health","FirstCategoryId":"93","ListUrlMain":"","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Many toxic metals are involved in the initiation and progression of DNA damage that can result in the activation of DNA damage response machinery at double- and single-stranded DNA; this response can result in global and gene-specific DNA alteration. The toxicological profiles from the Agency for Toxic Substances and Disease Registry (ATSDR) and several other studies have demonstrated the influence of metal exposure-induced genotoxic endpoints and epigenetic modifications. Our review systematically summarizes accumulating evidence from ATSDR toxicological profiles and the available literature that demonstrate a possible induction of various genotoxic endpoints and metal exposures. We include in this article studies on chromium, arsenic, nickel, lead, mercury, and zinc.
许多有毒金属参与了 DNA 损伤的启动和进展，可导致双链和单链 DNA 的 DNA 损伤反应机制被激活；这种反应可导致整体和特定基因的 DNA 改变。美国毒物和疾病登记署（ATSDR）的毒理学资料和其他一些研究表明，金属暴露诱发的基因毒性终点和表观遗传修饰具有影响力。我们的综述系统地总结了美国毒物与疾病登记署毒理学档案和现有文献中不断积累的证据，这些证据表明各种基因毒性终点和金属暴露可能会诱发基因毒性终点。本文包括对铬、砷、镍、铅、汞和锌的研究。
期刊介绍：
The Journal of Environmental Health (JEH) is published 10 times per year by the National Environmental Health Association and keeps readers up-to-date on current issues, new research, useful products and services, and employment opportunities. As the only direct link to the complete spectrum of environmental health topics, the JEH reaches more than 20,000 professionals working to solve problems in areas such as
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hazardous materials/toxic substances management,
institutional environmental health,
occupational safety and health,
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vector control,
wastewater management, and
water pollution control/water quality.
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