Nerol mitigates dexamethasone-induced skin aging by activating the Nrf2 signaling pathway in human dermal fibroblasts

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Life sciences Pub Date : 2024-09-03 DOI:10.1016/j.lfs.2024.123034

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Abstract

Collagen and hyaluronic acid are essential components of the dermis that collaborate to maintain skin elasticity and hydration due to their unique biochemical properties and interactions within the extracellular matrix. Prolonged exposure to glucocorticoids can induce skin aging, which manifests as diminished collagen content and hyaluronic acid levels in the dermis. Nerol, a monoterpene alcohol found in essential oils, was examined in this study for its potential to counteract glucocorticoid-induced skin aging and the underlying mechanism behind its effects. Our findings reveal that non-toxic concentrations of nerol treatment can reinstate collagen content and hyaluronic acid levels in human dermal fibroblasts treated with dexamethasone. Mechanistically, nerol mitigates dexamethasone-induced oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. The protective effects of nerol were significantly abrogated when the Nrf2 pathway was inhibited using the specific inhibitor ML385. In conclusion, nerol protects human dermal fibroblasts against glucocorticoid-induced skin aging by ameliorating oxidative stress via activation of the Nrf2 pathway, thereby highlighting its potential as a therapeutic agent for preventing and treating glucocorticoid-induced skin aging.

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橙花醇通过激活人真皮成纤维细胞中的 Nrf2 信号通路，缓解地塞米松诱导的皮肤老化。

胶原蛋白和透明质酸是真皮层的重要组成部分，由于其独特的生化特性和在细胞外基质中的相互作用，它们共同维持着皮肤的弹性和水合作用。长期接触糖皮质激素会诱发皮肤老化，表现为真皮层中胶原蛋白含量和透明质酸含量的减少。橙花醇是一种存在于精油中的单萜醇，本研究考察了它对抗糖皮质激素诱导的皮肤老化的潜力及其作用背后的潜在机制。我们的研究结果表明，无毒浓度的橙花醇可以恢复地塞米松处理的人体真皮成纤维细胞中的胶原蛋白含量和透明质酸水平。从机理上讲，橙花醇通过激活核因子红细胞2相关因子2（Nrf2）信号通路，减轻了地塞米松诱导的氧化应激。当使用特异性抑制剂 ML385 抑制 Nrf2 通路时，橙花醇的保护作用明显减弱。总之，橙花醇通过激活 Nrf2 通路改善氧化应激，从而保护人的真皮成纤维细胞免受糖皮质激素诱导的皮肤老化的影响，从而突出了其作为预防和治疗糖皮质激素诱导的皮肤老化的治疗剂的潜力。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.