{"title":"Emotional contagion builds resilience","authors":"Martin Metzger, Jose Donato Jr.","doi":"10.1126/science.adr9296","DOIUrl":null,"url":null,"abstract":"<div >In a world with multiple ongoing conflicts, an increasing number of people witness others in distress, either in person or online. Some develop anxiety disorders or even major depressive disease, whereas others become resilient to such distress, maintaining psychological wellbeing in the face of adversity. However, how resilience is established remains unclear. On page 1081 of this issue, Mondoloni <i>et al</i>. (<i>1</i>) report a brain circuit that promotes resilience in mice witnessing the suffering of cage mates—a phenomenon known as negative emotional contagion (NEC). This involves the release of serotonin (5-HT) from neurons originating in the raphe nuclei, a region in the brain stem, into a structure in the epithalamus called the habenula, where 5-HT dampens burst firing, a distinct firing pattern of habenular neurons. The findings elucidate the mechanisms involved in resilience and have potential implications for the treatment of anxiety and depression (see the figure).</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science","FirstCategoryId":"103","ListUrlMain":"https://www.science.org/doi/10.1126/science.adr9296","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
In a world with multiple ongoing conflicts, an increasing number of people witness others in distress, either in person or online. Some develop anxiety disorders or even major depressive disease, whereas others become resilient to such distress, maintaining psychological wellbeing in the face of adversity. However, how resilience is established remains unclear. On page 1081 of this issue, Mondoloni et al. (1) report a brain circuit that promotes resilience in mice witnessing the suffering of cage mates—a phenomenon known as negative emotional contagion (NEC). This involves the release of serotonin (5-HT) from neurons originating in the raphe nuclei, a region in the brain stem, into a structure in the epithalamus called the habenula, where 5-HT dampens burst firing, a distinct firing pattern of habenular neurons. The findings elucidate the mechanisms involved in resilience and have potential implications for the treatment of anxiety and depression (see the figure).
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