Pub Date : 2024-11-15Epub Date: 2024-11-14DOI: 10.1126/science.adu5824
Jennifer Couzin-Frankel
Co-authors say preliminary data on lecanemab fatalities don't support the paper's claims.
论文的共同作者说，有关莱卡奈单抗致死率的初步数据并不支持论文的说法。
{"title":"Preprint on Alzheimer's drug deaths ignites author dispute.","authors":"Jennifer Couzin-Frankel","doi":"10.1126/science.adu5824","DOIUrl":"10.1126/science.adu5824","url":null,"abstract":"<p><p>Co-authors say preliminary data on lecanemab fatalities don't support the paper's claims.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"717-718"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15Epub Date: 2024-11-14DOI: 10.1126/science.adu5821
Jocelyn Kaiser
Congress might serve as a bulwark, but some changes may be coming.
国会可能会充当堡垒，但一些变化可能会到来。
{"title":"Trump won. Is NIH in for a major shake-up?","authors":"Jocelyn Kaiser","doi":"10.1126/science.adu5821","DOIUrl":"10.1126/science.adu5821","url":null,"abstract":"<p><p>Congress might serve as a bulwark, but some changes may be coming.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"713-714"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junhua Lyu, Zhimin Gu, Yuannyu Zhang, Hieu S. Vu, Christophe Lechauve, Feng Cai, Hui Cao, Julia Keith, Valentina Brancaleoni, Francesca Granata, Irene Motta, Maria Domenica Cappellini, Lily Jun-Shen Huang, Ralph J. DeBerardinis, Mitchell J. Weiss, Min Ni, Jian Xu
Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. Glutamine synthetase (GS), one of the oldest functioning genes in evolution, is activated during erythroid maturation to detoxify ammonium generated from heme biosynthesis, which is up-regulated to support hemoglobin production. Loss of GS in mouse erythroid precursors caused ammonium accumulation and oxidative stress, impairing erythroid maturation and recovery from anemia. In β-thalassemia, GS activity is inhibited by protein oxidation, leading to glutamate and ammonium accumulation, whereas enhancing GS activity alleviates the metabolic and pathological defects. Our findings identify an evolutionarily conserved metabolic adaptation that could potentially be leveraged to treat common red blood cell disorders.
{"title":"A glutamine metabolic switch supports erythropoiesis","authors":"Junhua Lyu, Zhimin Gu, Yuannyu Zhang, Hieu S. Vu, Christophe Lechauve, Feng Cai, Hui Cao, Julia Keith, Valentina Brancaleoni, Francesca Granata, Irene Motta, Maria Domenica Cappellini, Lily Jun-Shen Huang, Ralph J. DeBerardinis, Mitchell J. Weiss, Min Ni, Jian Xu","doi":"10.1126/science.adh9215","DOIUrl":"10.1126/science.adh9215","url":null,"abstract":"<div >Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. Glutamine synthetase (GS), one of the oldest functioning genes in evolution, is activated during erythroid maturation to detoxify ammonium generated from heme biosynthesis, which is up-regulated to support hemoglobin production. Loss of GS in mouse erythroid precursors caused ammonium accumulation and oxidative stress, impairing erythroid maturation and recovery from anemia. In β-thalassemia, GS activity is inhibited by protein oxidation, leading to glutamate and ammonium accumulation, whereas enhancing GS activity alleviates the metabolic and pathological defects. Our findings identify an evolutionarily conserved metabolic adaptation that could potentially be leveraged to treat common red blood cell disorders.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":""},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15Epub Date: 2024-11-14DOI: 10.1126/science.adu5822
Gretchen Vogel
Scientists worry Donald Trump will leave WHO again and slash disease control programs.
科学家们担心唐纳德-特朗普会再次离开世卫组织，并削减疾病控制项目。
{"title":"'America first' could affect health worldwide.","authors":"Gretchen Vogel","doi":"10.1126/science.adu5822","DOIUrl":"10.1126/science.adu5822","url":null,"abstract":"<p><p>Scientists worry Donald Trump will leave WHO again and slash disease control programs.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"715"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15Epub Date: 2024-11-14DOI: 10.1126/science.adu5507
Jennifer Couzin-Frankel
An immune cell treatment that fights cancer is now taking aim at autoimmune disease.
一种抗癌的免疫细胞疗法现在正瞄准自身免疫性疾病。
{"title":"The counterattack.","authors":"Jennifer Couzin-Frankel","doi":"10.1126/science.adu5507","DOIUrl":"10.1126/science.adu5507","url":null,"abstract":"<p><p>An immune cell treatment that fights cancer is now taking aim at autoimmune disease.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"719-723"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15Epub Date: 2024-11-14DOI: 10.1126/science.adu5823
Sean Cummings
Saved from the scrapyard, unique ocean platform to be revamped before redeployment.
从废料场救出的独特海洋平台将在重新部署前进行改造。
{"title":"Famed flipping ship gets second shot at research.","authors":"Sean Cummings","doi":"10.1126/science.adu5823","DOIUrl":"https://doi.org/10.1126/science.adu5823","url":null,"abstract":"<p><p>Saved from the scrapyard, unique ocean platform to be revamped before redeployment.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"716"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baojun Yang, Yanbiao Sun, Max Minne, Yanhua Ge, Qianru Yue, Vera Goossens, Eliana Mor, Brenda Callebaut, Kevin Bevernaege, Johan M. Winne, Dominique Audenaert, Bert De Rybel
Oriented cell divisions are crucial for determining the overall morphology and size of plants, but what controls the onset and duration of this process remains largely unknown. Here, we identified a small molecule that activates root apical meristem (RAM) expression of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE13 (SPL13) a known player in the shoot’s juvenile-to-adult transition. This expression leads to oriented cell divisions in the RAM through SHORT ROOT (SHR) and cell cycle regulators. We further show that the RAM has distinct juvenile and adult phases typed by morphological and molecular characteristics and that SPL factors are crucially required for this transition in Arabidopsis and rice (Oryza sativa). In summary, we provide molecular insights into the age-dependent morphological changes occurring in the RAM during phase change.
{"title":"SPL13 controls a root apical meristem phase change by triggering oriented cell divisions","authors":"Baojun Yang, Yanbiao Sun, Max Minne, Yanhua Ge, Qianru Yue, Vera Goossens, Eliana Mor, Brenda Callebaut, Kevin Bevernaege, Johan M. Winne, Dominique Audenaert, Bert De Rybel","doi":"10.1126/science.ado4298","DOIUrl":"10.1126/science.ado4298","url":null,"abstract":"<div >Oriented cell divisions are crucial for determining the overall morphology and size of plants, but what controls the onset and duration of this process remains largely unknown. Here, we identified a small molecule that activates root apical meristem (RAM) expression of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE13 (SPL13) a known player in the shoot’s juvenile-to-adult transition. This expression leads to oriented cell divisions in the RAM through SHORT ROOT (SHR) and cell cycle regulators. We further show that the RAM has distinct juvenile and adult phases typed by morphological and molecular characteristics and that SPL factors are crucially required for this transition in <i>Arabidopsis</i> and rice (<i>Oryza sativa</i>). In summary, we provide molecular insights into the age-dependent morphological changes occurring in the RAM during phase change.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":""},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15Epub Date: 2024-11-14DOI: 10.1126/science.adu5818
{"title":"News at a glance.","authors":"","doi":"10.1126/science.adu5818","DOIUrl":"https://doi.org/10.1126/science.adu5818","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"710-711"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15Epub Date: 2024-11-14DOI: 10.1126/science.adu5820
Jeffrey Mervis
Trump agenda and a Republican Congress point to funding cuts and policy shifts.
特朗普议程和共和党国会指出要削减资金和改变政策。
{"title":"Research advocates see 'no good news for science'.","authors":"Jeffrey Mervis","doi":"10.1126/science.adu5820","DOIUrl":"https://doi.org/10.1126/science.adu5820","url":null,"abstract":"<p><p>Trump agenda and a Republican Congress point to funding cuts and policy shifts.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"712-713"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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