Giuseppe P. Gava, Laura Lefèvre, Tabitha Broadbelt, Stephen B. McHugh, Vítor Lopes-dos-Santos, Demi Brizee, Katja Hartwich, Hanna Sjoberg, Pavel V. Perestenko, Robert Toth, Andrew Sharott, David Dupret
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引用次数: 0
Abstract
New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the mouse hippocampus within a population activity space of highly correlated spike trains that prevents subsequent computation of a flexible (object-location) memory. This densely correlated firing structure developed over repeated mnemonic experience, gradually coupling neurons in the superficial sublayer of the CA1 stratum pyramidale to whole-population activity. Applying hippocampal theta-driven closed-loop optogenetic suppression to mitigate this neuronal recruitment during (food-context) memory formation relaxed the topological constraint on hippocampal coactivity and restored subsequent flexible (object-location) memory. These findings uncover an organizational principle for the peer-to-peer coactivity structure of the hippocampal cell population to meet memory demands.
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