Ambient catalyst-free oxidation reactions of aromatic amines using water radical cations†

IF 7.6 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical Science Pub Date : 2024-09-06 DOI:10.1039/D4SC04519J
Xiaoping Zhang, Pinghua Hu, Minmin Duan, Konstantin Chingin, Roman Balabin, Xinglei Zhang and Huanwen Chen
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Abstract

Water radical cations play a pivotal role in various scientific and industrial fields due to their unique reactivity and capacity to drive complex chemical transformations. Here we explored the formation of quaternary ammonium cations through the direct oxidation reaction of aromatic amines, facilitated by water radical cations within water microdroplets. This process was monitored via in situ mass spectrometry and occurs under ambient conditions, negating the need for traditional chemical catalysts or oxidants and achieving an impressive yield of approximately 80%. Additionally, we employed a multi-channel spray system and enhanced both the reactant concentration and flow rate, thereby enabling gram-scale synthesis. These findings not only demonstrate the effectiveness and eco-friendliness of microdroplet chemistry but also provide a new understanding of heterogeneous ˙OH generation channels, thereby boosting the synthetic efficiency and sustainability of chemical processes.

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水自由基阳离子对芳香胺的常温无催化剂氧化反应
水基阳离子因其独特的反应性和推动复杂化学变化的能力,在各种科学和工业领域发挥着举足轻重的作用。在此,我们探索了通过芳香胺的直接氧化反应形成季铵阳离子的过程,水基阳离子在水微滴中起到了促进作用。这一过程通过原位质谱法进行监测,在环境条件下进行,无需传统的化学催化剂或氧化剂,产率高达 80%。此外,我们还采用了多通道喷雾系统,提高了反应物浓度和流速,从而实现了克级合成。这些发现不仅证明了微滴化学的有效性和生态友好性,还提供了对异相-OH 生成通道的新认识,从而提高了化学过程的合成效率和可持续性。
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来源期刊
Chemical Science
Chemical Science CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
14.40
自引率
4.80%
发文量
1352
审稿时长
2.1 months
期刊介绍: Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.
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