Building a Kinetic Induced Voxel-Clustering Filter (KVCF) for Low-Dose Perfusion CT Imaging

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2024-03-17 DOI:10.1109/TRPMS.2024.3402272
Zixiang Chen;Yuxi Jin;Zhenxing Huang;Na Zhang;Kaiyi Liang;Guotao Quan;Dong Liang;Hairong Zheng;Zhanli Hu
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Abstract

Dynamic cerebral perfusion CT (PCT) is an effective imaging technique for the clinical diagnosis and therapy guidance of many kinds of cerebrovascular diseases (CVDs), but the large radiation dose imposed on a patient during repeated CT scans greatly limits its clinical applications. Achieving low-dose PCT imaging with the help of advanced and satisfactory imaging methods is needed. A kinetic-induced voxel-clustering filter (KVCF) is proposed in this work to help process noisy and distorted PCT images acquired from the low-dose CT scan protocols. In this new method, the intrinsic kinetic information of objective PCT images is extracted and effectively utilized to construct an image filter for every PCT frame. The new method is validated using both the simulated and clinical low-dose PCT data, and the peak signal-to-noise ratio (PSNR) and feature similarity (FSIM) are applied for quantitative evaluations of both the dynamic images and the calculated hemodynamic parametric maps. Compared to several existing methods, the proposed KVCF method produces the best qualitative and quantitative imaging effects. With satisfactory performance and high interpretability, KVCF is proven to be effective and implementable in the clinical low-dose PCT imaging tasks.
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构建用于低剂量灌注 CT 成像的动力学诱导体素聚类滤波器 (KVCF)
动态脑灌注 CT(PCT)是一种有效的成像技术,可用于多种脑血管疾病(CVD)的临床诊断和治疗指导,但重复 CT 扫描对患者造成的巨大辐射剂量极大地限制了其临床应用。因此,需要借助先进且令人满意的成像方法来实现低剂量 PCT 成像。本研究提出了一种动力学诱导体素聚类滤波器(KVCF),以帮助处理从低剂量 CT 扫描方案中获取的嘈杂和扭曲的 PCT 图像。在这种新方法中,客观 PCT 图像的内在动力学信息被提取并有效利用,从而为每个 PCT 帧构建图像滤波器。新方法利用模拟和临床低剂量 PCT 数据进行了验证,并应用峰值信噪比(PSNR)和特征相似性(FSIM)对动态图像和计算的血液动力学参数图进行了定量评估。与现有的几种方法相比,所提出的 KVCF 方法能产生最佳的定性和定量成像效果。KVCF 具有令人满意的性能和较高的可解释性,在临床低剂量 PCT 成像任务中被证明是有效和可实施的。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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