Fabrication of albumin-Ti3C2 MXene quantum dots-based nanohybrids for breast cancer imaging and synergistic photo/chemotherapeutics

IF 5.4 2区医学 Q1 BIOPHYSICS Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-03 DOI:10.1016/j.colsurfb.2024.114207

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Abstract

Advancement in the development of new materials with theranostic and phototherapeutic potential along with receptiveness to external stimuli has been persistently inspiring oncology research. Herein, titanium carbide-based MXene quantum dots (FHMQDs) have been synthesized and modified to take advantage of stimuli-responsive behavior and target specificity for breast cancer cells. With a size of around 3 nm, the developed FHMQDs demonstrate high fluorescent emission at around 460 nm. With ∼90 % encapsulation efficiency of doxorubicin (DOX), the developed system also offers rapid DOX release behavior when encountering an acidic pH (5.4). Further, the in vitro assessment of the developed FHMQDs on MDA-MB 231 breast cancer cells presents excellent target specificity to cancer cells which was reflected by its high cytotoxicity against cancer cells. Additionally, the outstanding photodynamic efficiency of FHMQDs due to excessive Reactive Oxygen Species (ROS) generating ability along with apoptosis promoting capability of FHMQDs in cancer cells demonstrates a synergistic approach in cancer theranostics. Encouragingly, the fabricated FHMQDs also exhibited fluorescent labelling and bioimaging capacity which makes it an incredible platform that ensures theranostic excellence in breast cancer research.

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制备基于白蛋白-Ti3C2 MXene 量子点的纳米混合物，用于乳腺癌成像和协同光/化学治疗。

具有治疗和光疗潜力并能接受外部刺激的新材料的开发进展一直激励着肿瘤学研究。在此，我们合成并修饰了基于碳化钛的 MXene 量子点（FHMQDs），以利用其刺激响应行为和对乳腺癌细胞的靶向特异性。所开发的 FHMQDs 尺寸约为 3 nm，在约 460 nm 处具有高荧光发射。所开发的系统对多柔比星（DOX）的包封效率高达 90%，在遇到酸性 pH 值（5.4）时还能快速释放 DOX。此外，对所开发的 FHMQDs 在 MDA-MB 231 乳腺癌细胞上的体外评估显示，它对癌细胞具有极佳的靶向特异性，这体现在它对癌细胞的高细胞毒性上。此外，由于 FHMQDs 产生过多活性氧（ROS）的能力以及促进癌细胞凋亡的能力，FHMQDs 具有出色的光动力效率，这表明在癌症治疗学中存在一种协同方法。令人鼓舞的是，制备的 FHMQDs 还具有荧光标记和生物成像能力，这使其成为一个令人难以置信的平台，确保在乳腺癌研究中实现卓越的治疗效果。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.