Exocrine pancreatic inflammation in canine diabetes mellitus – An active offender?

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary journal Pub Date : 2024-09-05 DOI:10.1016/j.tvjl.2024.106241
Arielle Johnson-Pitt , Brian Catchpole , Lucy J. Davison
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Abstract

The purpose of this review is to examine the current scientific literature regarding the interplay between the exocrine and endocrine pancreas, specifically the role of the exocrine pancreas in the pathogenesis of canine diabetes mellitus. β-cell death caused by exocrine pancreatic inflammation is thought to be an under-recognised contributor to diabetes mellitus in dogs, with up to 30 % of canine diabetic patients with concurrent evidence of pancreatitis at post-mortem examination. Current diagnostics for pancreatitis are imprecise, and treatments for both diseases individually have their own limitations: diabetes through daily insulin injections, which has both welfare and financial implications for the stakeholders, and pancreatitis through treatment of clinical signs, such as analgesia and anti-emetics, rather than targeted treatment of the underlying cause. This review will consider the evidence for exocrine pancreatic inflammation making an active contribution to pancreatic β-cell loss and insulin-deficiency diabetes in the dog and explore current and potential future diagnostic and treatment avenues to improve outcomes for these patients.

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犬糖尿病中的胰腺外分泌炎症--活跃的罪犯?
本综述旨在研究当前有关胰腺外分泌和内分泌之间相互作用的科学文献,特别是胰腺外分泌在犬糖尿病发病机制中的作用。由胰腺外分泌炎症引起的β细胞死亡被认为是犬糖尿病的一个未被充分认识到的因素,高达 30% 的犬糖尿病患者在死后检查时同时有胰腺炎的证据。目前对胰腺炎的诊断并不精确,而对这两种疾病的治疗也各有局限:糖尿病患者需要每天注射胰岛素,这对利益相关者的福利和经济都有影响;胰腺炎患者需要治疗临床症状,如镇痛和止吐,而不是针对根本原因进行治疗。本综述将考虑胰腺外分泌炎症对胰腺β细胞丢失和犬胰岛素缺乏性糖尿病有积极作用的证据,并探索当前和未来潜在的诊断和治疗途径,以改善这些患者的预后。
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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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