Association of nursing home antipsychotic reduction policies with antipsychotic use in community dwellers with dementia.

Antoinette B Coe, Tingting Zhang, Andrew R Zullo, Lauren B Gerlach, Lori A Daiello, Hiren Varma, Derrick Lo, Richa Joshi, Julie P W Bynum, Theresa I Shireman
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Abstract

Background: Antipsychotic and other psychotropic medication use is prevalent among community-dwelling older adults with dementia despite the potential for adverse effects. Two Centers for Medicare & Medicaid Services (CMS) initiatives, the National Partnership to Improve Dementia Care ("the Partnership") and the Five Star Quality Rating System for antipsychotic use reporting, have been successful in reducing antipsychotic use in nursing home residents. We assessed if these initiatives had a spillover effect in antipsychotic and other psychotropic medication use among community dwellers with dementia due to potential overlap in prescribers across settings.

Methods: Among community-dwelling older adults with dementia, we examined psychotropic medication class use (i.e., antipsychotics, antidepressants, anxiolytics, anticonvulsants/mood stabilizers, antidementia) in 2010-2017 Medicare fee-for-service claims using interrupted time series analyses across three periods ("Pre-Partnership": July 1, 2010 to March 31, 2012; "Post-Partnership": April 1, 2012 to January 31, 2015; "Five Star Quality Rating": February 1, 2015 to December 31, 2017).

Results: We included 1,289,401 community dwellers with dementia contributing 26,609,697 person-months. The mean age was 80 years, most were female (70%), approximately 80% were non-Hispanic Whites, 10% were non-Hispanic Blacks, and 5% were Hispanic ethnicity. Antipsychotic use was declining pre-Partnership (β = -0.06, 95% CI: -0.08, -0.05) and post-Partnership (β = -0.02, 95% CI: -0.02, -0.01). Post-Five Star Quality Rating, antipsychotic use remained stable with a nearly flat slope (β = -0.01, 95% CI: -0.01, 0.00). Anticonvulsant and antidepressant use increased and anxiolytic and antidementia medication use decreased among community-dwelling older adults with dementia.

Conclusions: These two CMS policies on antipsychotic use for nursing home residents were not associated with a spillover effect to community-dwelling older adults with dementia. Strategies to monitor the appropriateness of psychotropic medication use may be warranted for community-dwellers with dementia.

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疗养院减少使用抗精神病药物的政策与社区痴呆症患者使用抗精神病药物的关系。
背景:在社区居住的老年痴呆症患者中,抗精神病药物和其他精神药物的使用非常普遍,尽管这些药物可能会产生不良反应。美国联邦医疗保险与医疗补助服务中心(CMS)的两项举措--"改善痴呆症护理全国合作计划"(以下简称 "合作计划")和 "抗精神病药物使用报告五星质量评级系统"--成功地减少了疗养院居民的抗精神病药物使用。我们评估了这些措施是否会因处方者在不同环境中的潜在重叠而对患有痴呆症的社区居民使用抗精神病药和其他精神药物产生溢出效应:在患有痴呆症的社区居住老年人中,我们采用间断时间序列分析法研究了三个时期("合作前":2010 年 7 月 1 日至 2011 年 3 月 31 日;"合作后":2010 年 7 月 1 日至 2011 年 3 月 31 日;"合作前":2010 年 7 月 1 日至 2011 年 3 月 31 日)的 2010-2017 年医疗保险付费服务索赔中精神药物类别(即抗精神病药物、抗抑郁药物、抗焦虑药物、抗惊厥药物/情绪稳定剂、抗痴呆药物)的使用情况:合作前":2010 年 7 月 1 日至 2012 年 3 月 31 日;"合作后":2012 年 4 月 1 日至 2012 年 1 月 31 日:合作后":2012 年 4 月 1 日至 2015 年 1 月 31 日;"五星质量评级":2015 年 2 月 1 日至 12 月 31 日:结果:我们纳入了 1,289,401 名患有痴呆症的社区居民,共计 26,609,697 人月。平均年龄为 80 岁,大多数为女性(70%),约 80% 为非西班牙裔白人,10% 为非西班牙裔黑人,5% 为西班牙裔。合作前(β = -0.06,95% CI:-0.08,-0.05)和合作后(β = -0.02,95% CI:-0.02,-0.01),抗精神病药物的使用呈下降趋势。五星质量评级后,抗精神病药物的使用保持稳定,斜率几乎持平(β = -0.01,95% CI:-0.01,0.00)。在社区居住的老年痴呆症患者中,抗惊厥药和抗抑郁药的使用有所增加,抗焦虑药和抗痴呆药的使用有所减少:这两项 CMS 针对疗养院居民使用抗精神病药物的政策并未对社区居住的老年痴呆症患者产生溢出效应。对于社区居住的痴呆症患者来说,可能需要采取一些策略来监控精神药物使用的适当性。
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