Apple vescicles: Revolutionary gut microbiota treatment for Inflammatory Bowel Disease

IF 4.8 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Bioscience Pub Date : 2024-09-05 DOI:10.1016/j.fbio.2024.105052
Letizia Ferroni , Andrea Rubini , Paolo Bargellini , Elena Tremoli , Ilenia Pia Cappucci , Ugo D'Amora , Alfredo Ronca , Giulia Calogero , Paolo Cortellini Panini , Gisella Bettini , Cristiana Piccoli , Giuseppe Rubini , Lucia Sileo , Maria Pia Cavaleri , Luca Lovatti , Barbara Zavan
{"title":"Apple vescicles: Revolutionary gut microbiota treatment for Inflammatory Bowel Disease","authors":"Letizia Ferroni ,&nbsp;Andrea Rubini ,&nbsp;Paolo Bargellini ,&nbsp;Elena Tremoli ,&nbsp;Ilenia Pia Cappucci ,&nbsp;Ugo D'Amora ,&nbsp;Alfredo Ronca ,&nbsp;Giulia Calogero ,&nbsp;Paolo Cortellini Panini ,&nbsp;Gisella Bettini ,&nbsp;Cristiana Piccoli ,&nbsp;Giuseppe Rubini ,&nbsp;Lucia Sileo ,&nbsp;Maria Pia Cavaleri ,&nbsp;Luca Lovatti ,&nbsp;Barbara Zavan","doi":"10.1016/j.fbio.2024.105052","DOIUrl":null,"url":null,"abstract":"<div><p>Inflammatory bowel disease (IBD) causes chronic inflammation of the digestive system and can affect both humans and household pets like dogs. Despite extensive research, a definitive cure remains elusive. This study investigates the therapeutic potential of apple-derived extracellular vesicles (ADEVs) in canine IBD. ADEVs, isolated from 'Golden Delicious' apples, were orally administered to dogs with IBD over a ten-day period. Microbiota analysis, clinical assessments, endoscopic examinations, and ultrasound imaging showed a significant reduction in disease severity and post-treatment symptoms. The results indicate that ADEVs regulate intestinal microorganism growth and interact with host cells. In particular IgA and calprotectine level riched physiological level, as well as microbiota and intestinal mucose. These results can explained thanks to the soothing effect of ADEVs on IBD may be due to a synergistic regulatory impact on both intestinal flora and the host's inflammatory response. Overall, these findings suggest a promising new avenue for IBD treatment.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"62 ","pages":"Article 105052"},"PeriodicalIF":4.8000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212429224014822/pdfft?md5=e16d8c1d392877a663bbe3c3a85ce8bd&pid=1-s2.0-S2212429224014822-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Bioscience","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212429224014822","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Inflammatory bowel disease (IBD) causes chronic inflammation of the digestive system and can affect both humans and household pets like dogs. Despite extensive research, a definitive cure remains elusive. This study investigates the therapeutic potential of apple-derived extracellular vesicles (ADEVs) in canine IBD. ADEVs, isolated from 'Golden Delicious' apples, were orally administered to dogs with IBD over a ten-day period. Microbiota analysis, clinical assessments, endoscopic examinations, and ultrasound imaging showed a significant reduction in disease severity and post-treatment symptoms. The results indicate that ADEVs regulate intestinal microorganism growth and interact with host cells. In particular IgA and calprotectine level riched physiological level, as well as microbiota and intestinal mucose. These results can explained thanks to the soothing effect of ADEVs on IBD may be due to a synergistic regulatory impact on both intestinal flora and the host's inflammatory response. Overall, these findings suggest a promising new avenue for IBD treatment.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
苹果囊泡治疗炎症性肠病的革命性肠道微生物群疗法
炎症性肠病(IBD)是消化系统的慢性炎症,既可影响人类,也可影响狗等家养宠物。尽管进行了广泛的研究,但仍无法找到确切的治疗方法。本研究调查了苹果衍生细胞外囊泡(ADEVs)对犬 IBD 的治疗潜力。从 "金美味 "苹果中分离出的 ADEVs 被口服给患有 IBD 的狗,为期十天。微生物群分析、临床评估、内窥镜检查和超声波成像结果显示,疾病严重程度和治疗后症状明显减轻。结果表明,ADEVs 可调节肠道微生物的生长并与宿主细胞相互作用。尤其是 IgA 和 calprotectine 含量提高到了生理水平,微生物群和肠粘液糖的含量也提高了。这些结果可以解释为,ADEVs 对 IBD 的舒缓作用可能是由于其对肠道菌群和宿主炎症反应的协同调节作用。总之,这些发现为治疗 IBD 提供了一条前景广阔的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Food Bioscience
Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.40
自引率
5.80%
发文量
671
审稿时长
27 days
期刊介绍: Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.
期刊最新文献
Advances in structure-hypoglycemic activity relationship and mechanisms of berry polysaccharides The roles of flavonoids in the treatment of inflammatory bowel disease and extraintestinal manifestations: A review Evaluation of bioaccessibility and bioavailability of dietary bioactives and their application in food systems Nutritional characteristics and physicochemical properties of ancient wheat species for food applications Potential applications of antimicrobial peptides from edible insects in the food supply chain: Uses in agriculture, packaging, and human nutrition
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1