Dina A. Kulikova, Alina V. Bespalova, Elena S. Zelentsova, Mikhail B. Evgen’ev, Sergei Yu. Funikov
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引用次数: 0
Abstract
The phenomenon of paramutation describes the interaction between two alleles, in which one allele initiates inherited epigenetic conversion of another allele without affecting the DNA sequence. Epigenetic transformations due to paramutation are accompanied by the change in DNA and/or histone methylation patterns, affecting gene expression. Studies of paramutation in plants and animals have identified small non-coding RNAs as the main effector molecules required for the initiation of epigenetic changes in gene loci. Due to the fact that small non-coding RNAs can be transmitted across generations, the paramutation effect can be inherited and maintained in a population. In this review, we will systematically analyze examples of paramutation in different living systems described so far, highlighting common and different molecular and genetic aspects of paramutation between organisms, and considering the role of this phenomenon in evolution.
副变异现象描述了两个等位基因之间的相互作用，其中一个等位基因在不影响 DNA 序列的情况下启动另一个等位基因的遗传表观遗传转换。副变异导致的表观遗传转化伴随着 DNA 和/或组蛋白甲基化模式的改变，从而影响基因表达。对动植物副变异的研究发现，小的非编码 RNA 是启动基因位点表观遗传变化所需的主要效应分子。由于小非编码 RNA 可以跨代传递，因此参变效应可以在种群中遗传和维持。在这篇综述中，我们将系统分析迄今为止描述的不同生物系统中的参数突变实例，强调不同生物之间参数突变的分子和遗传方面的共性和差异，并考虑这种现象在进化中的作用。
期刊介绍：
Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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