Biofilm-specific determinants of enterococci pathogen

IF 2.3 3区生物学 Q3 MICROBIOLOGY Archives of Microbiology Pub Date : 2024-09-09 DOI:10.1007/s00203-024-04119-9

Rohit Ruhal, Abhijeet Sahu, Tushar Koujalagi, Ankumoni Das, Hema Prasanth, Rashmi Kataria

{"title":"Biofilm-specific determinants of enterococci pathogen","authors":"Rohit Ruhal, Abhijeet Sahu, Tushar Koujalagi, Ankumoni Das, Hema Prasanth, Rashmi Kataria","doi":"10.1007/s00203-024-04119-9","DOIUrl":null,"url":null,"abstract":"<div><p>Amongst all <i>Enterococcus spp</i>., <i>E. faecalis</i> and <i>E. faecium</i> are most known notorious pathogen and their biofilm formation has been associated with endocarditis, oral, urinary tract, and wound infections. Biofilm formation involves a pattern of initial adhesion, microcolony formation, and mature biofilms. The initial adhesion and microcolony formation involve numerous surface adhesins e.g. pili Ebp and polysaccharide Epa. The mature biofilms are maintained by eDNA, It’s worth noting that phage-mediated dispersal plays a prominent role. Further, the involvement of peptide pheromones in regulating biofilm maintenance sets it apart from other pathogens and facilitating the horizontal transfer of resistance genes. The role of <i>fsr</i> based regulation by regulating <i>gelE</i> expression is also discussed. Thus, we provide a concise overview of the significant determinants at each stage of <i>Enterococcus</i> spp. biofilm formation. These elements could serve as promising targets for antibiofilm strategies.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"206 10","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Microbiology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s00203-024-04119-9","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Amongst all Enterococcus spp., E. faecalis and E. faecium are most known notorious pathogen and their biofilm formation has been associated with endocarditis, oral, urinary tract, and wound infections. Biofilm formation involves a pattern of initial adhesion, microcolony formation, and mature biofilms. The initial adhesion and microcolony formation involve numerous surface adhesins e.g. pili Ebp and polysaccharide Epa. The mature biofilms are maintained by eDNA, It’s worth noting that phage-mediated dispersal plays a prominent role. Further, the involvement of peptide pheromones in regulating biofilm maintenance sets it apart from other pathogens and facilitating the horizontal transfer of resistance genes. The role of fsr based regulation by regulating gelE expression is also discussed. Thus, we provide a concise overview of the significant determinants at each stage of Enterococcus spp. biofilm formation. These elements could serve as promising targets for antibiofilm strategies.

Graphical abstract

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肠球菌病原体的生物膜特异性决定因素。

在所有肠球菌属中，粪肠球菌和粪肠球菌是最著名的病原体，它们的生物膜形成与心内膜炎、口腔、泌尿道和伤口感染有关。生物膜的形成包括初始粘附、微菌落形成和成熟生物膜。最初的粘附和微菌落形成涉及许多表面粘附素，如纤毛 Ebp 和多糖 Epa。值得注意的是，噬菌体介导的传播起着重要作用。此外，肽信息素参与调节生物膜的维持，使其有别于其他病原体，并促进了抗性基因的水平转移。我们还讨论了基于 fsr 的调节作用，即调节 gelE 的表达。因此，我们简要概述了肠球菌属生物膜形成过程中每个阶段的重要决定因素。这些因素可作为抗生物膜策略的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Archives of Microbiology 生物-微生物学

CiteScore

4.90

自引率

3.60%

发文量

601

审稿时长

3 months

期刊介绍： Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.