Predictive value of disease activity signs in vitiligo: An observational study

IF 3.5 3区 医学 Q1 DERMATOLOGY Experimental Dermatology Pub Date : 2024-09-09 DOI:10.1111/exd.15167
Liesbeth Delbaere, Jolien Duponselle, Sandrine Herbelet, Reinhart Speeckaert, Nanja van Geel
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Abstract

The progression of vitiligo is unpredictable, emphasizing the need to identify periods of activity early for tailored treatment. Confetti-like depigmentation, hypochromic areas/borders and Koebner's phenomenon are clinical visible signs associated with disease activity in vitiligo. However, their true clinical significance requires further investigation using standardized scoring systems. In the present study, the Vitiligo Signs of Activity Score (VSAS) and the Vitiligo Disease Activity Score (VDAS) were applied to assess disease activity signs and disease progression over time, respectively. Individuals with at least one disease activity sign had a 76.9% likelihood of having active vitiligo. The simultaneous presence of multiple signs or their appearance across body locations increased the likelihood to 94% and 87.1%, respectively. Patients with no disease activity signs had a 60.3% likelihood of having stable disease. This research provides an important nuance about the disease activity signs in vitiligo, which may help guide disease management. The risk of active disease increases when at least two types of vitiligo activity signs are present, or when they are present on different body locations. However, the absence of vitiligo activity signs does not rule out active vitiligo.

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白癜风疾病活动体征的预测价值:一项观察性研究。
白癜风的病情发展难以预测,因此需要及早识别活动期,以便进行有针对性的治疗。纸屑状脱色、低色素区/边界和科布纳现象是与白癜风疾病活动相关的临床可见体征。然而,它们真正的临床意义还需要使用标准化评分系统进行进一步研究。在本研究中,白癜风活动体征评分(VSAS)和白癜风疾病活动评分(VDAS)分别用于评估疾病活动体征和疾病随时间的进展情况。至少有一种疾病活动迹象的患者有76.9%的可能性患有活动性白癜风。同时出现多种体征或体征出现在身体不同部位的可能性分别增加到94%和87.1%。没有疾病活动迹象的患者病情稳定的可能性为60.3%。这项研究提供了有关白癜风疾病活动迹象的一个重要细微差别,这可能有助于指导疾病管理。如果至少有两种白癜风活动迹象,或者这些迹象出现在不同的身体部位,那么疾病活动的风险就会增加。但是,没有白癜风活动征兆并不能排除活动性白癜风。
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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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