Laetitia Gay, Valérie Desquiret-Dumas, Nicolas Nagot, Clara Rapenne, Philippe Van de Perre, Pascal Reynier, Jean-Pierre Molès
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引用次数: 0
Abstract
Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged. Quantitative defects and structural rearrangements of mitochondrial DNA accumulate in post-mitotic tissues as recently reported long after SARS-CoV-2 or HIV infection, or following antiviral therapy. These observations are consistent with the “hit-and-run” concept proposed decades ago to explain viro-induced cell transformation and it could apply to delayed post-viral onsets of symptoms and advocate for complementary supportive care. Thus, according to this concept, following exposure to viruses or antiviral agents, mitochondrial damage could evolve into an autonomous clinical condition. It also establishes a pathogenic link between communicable and non-communicable chronic diseases.
线粒体对大多数细胞的功能至关重要。病毒会劫持线粒体机制,挪用能量供应或绕过防御机制。许多线粒体功能障碍在病毒感染治疗或未治疗后恢复后仍然存在,尤其是当线粒体 DNA 永久受损时。最近有报道称,在 SARS-CoV-2 或 HIV 感染后很长时间,或在抗病毒治疗后,线粒体 DNA 的数量缺陷和结构重排会在有丝分裂后组织中累积。这些观察结果与几十年前为解释病毒诱导的细胞转化而提出的 "打了就跑 "概念相一致,它可适用于病毒感染后症状的延迟出现,并提倡辅助性支持治疗。因此,根据这一概念,在接触病毒或抗病毒药物后,线粒体损伤可能演变为一种独立的临床症状。它还在传染性和非传染性慢性疾病之间建立了致病联系。
期刊介绍:
The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells.
The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists.
The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.