{"title":"Coordination of joint movement during gait in knee osteoarthritis: Insights from uncontrolled manifold analysis","authors":"","doi":"10.1016/j.jbiomech.2024.112305","DOIUrl":null,"url":null,"abstract":"<div><p>This study investigated the covariate structure of each segmental angle that stabilize the center of mass (COM) in the mediolateral and vertical directions in response to knee joint movement in individuals with knee osteoarthritis (KOA) using uncontrolled manifold (UCM) analysis. Twenty individuals with KOA and 13 healthy controls participated in this cross-sectional study. Kinematic and kinetic data were collected during level walking. UCM analysis was used to determine the covariance structure of segment angles stabilizing the COM in the mediolateral and vertical directions. The results indicated reduced knee flexion movement during the stance phase in the KOA group. In the mediolateral direction, the KOA group exhibited increased kinematic synergy stabilizing the COM. However, in the vertical direction, decreased kinematic synergy was observed. KOA group demonstrated greater trial-to-trial variances in segmental angles constituting the knee joint, suggesting enhanced covariance structure attempting to stabilize the COM in the mediolateral direction but increasing variability that destabilizes the COM in the vertical direction. Furthermore, decreased knee flexion movement during loading response may lead to reduced vertical kinematic synergy. In conclusion, these findings underscore the need to address improving knee flexion movement during the loading response to prevent osteoarthritis progression in patients with KOA. It provides insights into interventions focusing on improving knee flexion and enhancing kinematic synergy in the vertical direction, potentially benefiting patients with KOA.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomechanics","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002192902400383X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigated the covariate structure of each segmental angle that stabilize the center of mass (COM) in the mediolateral and vertical directions in response to knee joint movement in individuals with knee osteoarthritis (KOA) using uncontrolled manifold (UCM) analysis. Twenty individuals with KOA and 13 healthy controls participated in this cross-sectional study. Kinematic and kinetic data were collected during level walking. UCM analysis was used to determine the covariance structure of segment angles stabilizing the COM in the mediolateral and vertical directions. The results indicated reduced knee flexion movement during the stance phase in the KOA group. In the mediolateral direction, the KOA group exhibited increased kinematic synergy stabilizing the COM. However, in the vertical direction, decreased kinematic synergy was observed. KOA group demonstrated greater trial-to-trial variances in segmental angles constituting the knee joint, suggesting enhanced covariance structure attempting to stabilize the COM in the mediolateral direction but increasing variability that destabilizes the COM in the vertical direction. Furthermore, decreased knee flexion movement during loading response may lead to reduced vertical kinematic synergy. In conclusion, these findings underscore the need to address improving knee flexion movement during the loading response to prevent osteoarthritis progression in patients with KOA. It provides insights into interventions focusing on improving knee flexion and enhancing kinematic synergy in the vertical direction, potentially benefiting patients with KOA.
期刊介绍:
The Journal of Biomechanics publishes reports of original and substantial findings using the principles of mechanics to explore biological problems. Analytical, as well as experimental papers may be submitted, and the journal accepts original articles, surveys and perspective articles (usually by Editorial invitation only), book reviews and letters to the Editor. The criteria for acceptance of manuscripts include excellence, novelty, significance, clarity, conciseness and interest to the readership.
Papers published in the journal may cover a wide range of topics in biomechanics, including, but not limited to:
-Fundamental Topics - Biomechanics of the musculoskeletal, cardiovascular, and respiratory systems, mechanics of hard and soft tissues, biofluid mechanics, mechanics of prostheses and implant-tissue interfaces, mechanics of cells.
-Cardiovascular and Respiratory Biomechanics - Mechanics of blood-flow, air-flow, mechanics of the soft tissues, flow-tissue or flow-prosthesis interactions.
-Cell Biomechanics - Biomechanic analyses of cells, membranes and sub-cellular structures; the relationship of the mechanical environment to cell and tissue response.
-Dental Biomechanics - Design and analysis of dental tissues and prostheses, mechanics of chewing.
-Functional Tissue Engineering - The role of biomechanical factors in engineered tissue replacements and regenerative medicine.
-Injury Biomechanics - Mechanics of impact and trauma, dynamics of man-machine interaction.
-Molecular Biomechanics - Mechanical analyses of biomolecules.
-Orthopedic Biomechanics - Mechanics of fracture and fracture fixation, mechanics of implants and implant fixation, mechanics of bones and joints, wear of natural and artificial joints.
-Rehabilitation Biomechanics - Analyses of gait, mechanics of prosthetics and orthotics.
-Sports Biomechanics - Mechanical analyses of sports performance.