Recent advances and trends in optical devices and sensors for hydrogen peroxide detection

IF 11.8 1区 化学 Q1 CHEMISTRY, ANALYTICAL Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI:10.1016/j.trac.2024.117948
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Abstract

Hydrogen peroxide (H2O2) is a critically important, vital biomarker and hence a highly relevant analyte in a broad range of bioanalytical applications. The most recent trends furthering the ability of its reliable, reproducible, and sensitive quantification include the development of non-biological enzyme mimics, the investigation of smartphone cameras as transducers and detectors, and the continued development of semi-reversible and reversible detection strategies. While the non-biological catalysts offer stability-related advantages over enzymes while providing equally good limits of detection, critical questions regarding toxicity, persistence, (bio)accumulation, and overall environmental footprint need to be answered. In the case of heavy metal-based strategies a replacement by non-toxic, renewable alternatives should be an obvious research need. Signal recording has seen a dramatic change toward smartphones, with their ever-improving computing and image-acquisition abilities. Yet, with the sheer number of different camera and phone models progress can be difficult to assess, as reproducibility and comparability of results and experimental set-ups are too often elusive. In the area of semi-reversible sensors flow injection analysis (FIA) coupled with chemiluminescence (CL) remains the most advanced system. In the case of fully reversible sensors, research points toward oxygen-based sensing to be the most reliable. Analyzing publications from 2018 to 2024, it is not surprising that the important analytical figures of merit of low limits of detection (LODs), broad quantitation ranges, faster response and regeneration times combined with novel (reversible) probes continue to be and should remain central focus of future developments.

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过氧化氢检测光学设备和传感器的最新进展和趋势
过氧化氢(H2O2)是一种极其重要的重要生物标志物,因此在广泛的生物分析应用中是一种高度相关的分析物。为进一步提高其可靠、可重现和灵敏的定量能力,最近的发展趋势包括开发非生物酶模拟物、研究智能手机摄像头作为传感器和检测器,以及继续开发半可逆和可逆检测策略。与酶相比,非生物催化剂具有稳定性方面的优势,同时提供同样好的检测限,但有关毒性、持久性、(生物)积累和总体环境足迹等关键问题仍有待回答。对于以重金属为基础的策略,研究人员显然需要用无毒、可再生的替代品来替代。随着智能手机计算能力和图像采集能力的不断提高,信号记录技术也发生了巨大变化。然而,由于不同型号的相机和手机数量众多,进展情况难以评估,因为结果和实验装置的可重复性和可比性往往难以捉摸。在半可逆传感器领域,结合化学发光(CL)的流动注射分析(FIA)仍然是最先进的系统。在全可逆传感器方面,研究表明基于氧气的传感是最可靠的。分析 2018 年至 2024 年发表的论文,我们不难发现,低检测限 (LOD)、宽定量范围、更快的响应和再生时间等重要的分析性能指标与新型(可逆)探针相结合,将继续成为并应继续成为未来发展的核心重点。
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来源期刊
Trends in Analytical Chemistry
Trends in Analytical Chemistry 化学-分析化学
CiteScore
20.00
自引率
4.60%
发文量
257
审稿时长
3.4 months
期刊介绍: TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.
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