Trends in Analytical Chemistry最新文献

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Microneedle wearables in advanced microsystems: Unlocking next-generation biosensing with AI

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-27 DOI: 10.1016/j.trac.2025.118208

Ghazala Ashraf , Khalil Ahmed , Ayesha Aziz , Muhammad Asif , Jilie Kong , Xueen Fang

Wearable electronics have transformed health monitoring, but the non-invasive, real-time extraction of biomarkers from interstitial fluid (ISF) remains a complex challenge. Microneedle (MN) technologies, integrated with bioelectronics and artificial intelligence (AI), provide a promising solution for continuous health monitoring and personalized therapy. This review explores the design of MN platforms and key sampling mediums, highlighting their role in advanced biosensing applications. It delves into conventional and emerging sensing modalities detailing their integration strategies. Additionally, MN-based assays for biomarkers including glucose, lactate, pH, electrolytes, nucleic acids, and proteins are examined, emphasizing their potential in early disease diagnostics. The review highlights key challenges in the clinical translation of MN-based devices and the integration of AI for improved biomarker calibration. Emerging materials and AI-driven MN platforms show promise for advancing personalized, real-time diagnostics and therapies. However, overcoming issues with ISF biomarker variability, data reliability, and scalability is crucial for their broader clinical adoption.

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引用次数: 0

Phenolic compounds detection and quantification in whole grains: A comprehensive review of recent advancements in analytical methods

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-26 DOI: 10.1016/j.trac.2025.118215

Huanhuan Li , Xorlali Nunekpeku , Selorm Yao-Say Solomon Adade , Wei Sheng , Bridget Ama Kwadzokpui , Efakor Beloved Ahlivia , Quansheng Chen

Phenolic compounds are the most abundant antioxidants in the daily diet and are extensively distributed in plants and plant-derived food sources, including whole grains. Over the past decades, there has been a growing scientific focus on their diverse contributions to human health, given their array of bioactivities encompassing antioxidant, anti-inflammatory, anti-cancer, neuroprotective properties, among others. Hence, the quantification and examination of these compounds stand as fundamental basis of natural product exploration. Many efforts have been undertaken to provide highly sensitive and selective analytical approaches for their identification and characterization. To furnish novel perspectives for future advancement, the present review describes and discusses recent advancements in analytical methodologies for phenolic compound analysis in whole grains, spanning from traditional solvent-based to more robust modern and green extraction methodologies, spectrophotometry, and chromatography, non-destructive spectroscopic methods, and emergent technologies such as biosensors, while exploring into their current challenges and future prospects.

{"title":"Phenolic compounds detection and quantification in whole grains: A comprehensive review of recent advancements in analytical methods","authors":"Huanhuan Li , Xorlali Nunekpeku , Selorm Yao-Say Solomon Adade , Wei Sheng , Bridget Ama Kwadzokpui , Efakor Beloved Ahlivia , Quansheng Chen","doi":"10.1016/j.trac.2025.118215","DOIUrl":"10.1016/j.trac.2025.118215","url":null,"abstract":"<div><div>Phenolic compounds are the most abundant antioxidants in the daily diet and are extensively distributed in plants and plant-derived food sources, including whole grains. Over the past decades, there has been a growing scientific focus on their diverse contributions to human health, given their array of bioactivities encompassing antioxidant, anti-inflammatory, anti-cancer, neuroprotective properties, among others. Hence, the quantification and examination of these compounds stand as fundamental basis of natural product exploration. Many efforts have been undertaken to provide highly sensitive and selective analytical approaches for their identification and characterization. To furnish novel perspectives for future advancement, the present review describes and discusses recent advancements in analytical methodologies for phenolic compound analysis in whole grains, spanning from traditional solvent-based to more robust modern and green extraction methodologies, spectrophotometry, and chromatography, non-destructive spectroscopic methods, and emergent technologies such as biosensors, while exploring into their current challenges and future prospects.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118215"},"PeriodicalIF":11.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent developments of imaged capillary isoelectric focusing technology for in-depth biopharmaceutical characterization

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-26 DOI: 10.1016/j.trac.2025.118212

Tao Bo , Feng Yang , Bo Yan , David A. Michels , Tiemin Huang , Janusz Pawliszyn

Imaged capillary isoelectric focusing (icIEF) has made remarkable strides in recent years, presenting the biopharmaceutical industry with a range of innovative solutions to characterize protein charge heterogeneity and streamline the development and manufacturing of biologics. This review highlights the latest advancements in icIEF technology for comprehensive biopharmaceutical characterization. Key innovations, including the development of critical reagents and capillary coatings, advanced icIEF fractionation, cutting-edge icIEF-MS online coupling, and novel applications for protein bio-interactions, are redefining icIEF analytical methodologies and broadening their applicability. These breakthroughs significantly enhance the characterization of complex therapeutic proteins, aiding researchers in mitigating challenges and setbacks during drug development and manufacturing. In describing these advances, we delve into multidisciplinary concepts spanning biology, chemistry, instrument design, and workflow optimization, aiming to inspire further innovations and insights in this dynamic, rapidly evolving field. Furthermore, this review traces the origins and 30-year evolution of icIEF technology by illustrating its continuous progression and expanding impact over time.

{"title":"Recent developments of imaged capillary isoelectric focusing technology for in-depth biopharmaceutical characterization","authors":"Tao Bo , Feng Yang , Bo Yan , David A. Michels , Tiemin Huang , Janusz Pawliszyn","doi":"10.1016/j.trac.2025.118212","DOIUrl":"10.1016/j.trac.2025.118212","url":null,"abstract":"<div><div>Imaged capillary isoelectric focusing (icIEF) has made remarkable strides in recent years, presenting the biopharmaceutical industry with a range of innovative solutions to characterize protein charge heterogeneity and streamline the development and manufacturing of biologics. This review highlights the latest advancements in icIEF technology for comprehensive biopharmaceutical characterization. Key innovations, including the development of critical reagents and capillary coatings, advanced icIEF fractionation, cutting-edge icIEF-MS online coupling, and novel applications for protein bio-interactions, are redefining icIEF analytical methodologies and broadening their applicability. These breakthroughs significantly enhance the characterization of complex therapeutic proteins, aiding researchers in mitigating challenges and setbacks during drug development and manufacturing. In describing these advances, we delve into multidisciplinary concepts spanning biology, chemistry, instrument design, and workflow optimization, aiming to inspire further innovations and insights in this dynamic, rapidly evolving field. Furthermore, this review traces the origins and 30-year evolution of icIEF technology by illustrating its continuous progression and expanding impact over time.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118212"},"PeriodicalIF":11.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress of black phosphorus quantum dots: Synthesis method, biological characteristics, and biomedical applications

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-26 DOI: 10.1016/j.trac.2025.118214

Yi He , Fangyang Shi , Yaoling Han , Runze Li , Jie Wu , Wei Zhao , Dongsheng Yu

Zero-dimensional (0D) black phosphorus quantum dots (BPQDs), a novel manifestation of black phosphorus (BP), have garnered significant attention due to their exceptional properties and vast potential across various applications, positioning them as a promising functional nanomaterial in the biomedical field. Notable for their ease of functionalization, distinctive optical and electrical properties, excellent biocompatibility, and large specific surface area, BPQDs have been extensively investigated in bioimaging, biosensing, drug delivery, and cancer therapy. This review focuses on the synthesis methods, optical and electrical properties, biocompatibility, and biomedical applications of BPQDs, while also addressing future opportunities and challenges.

引用次数: 0

The role and choice of molecular descriptors for predicting retention times in HPLC: A comprehensive review

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-25 DOI: 10.1016/j.trac.2025.118207

Elena Bandini , Ardiana Kajtazi , Roman Szucs , Frédéric Lynen

This review explores the essential role of molecular descriptors (MDs) and their selection for prediction modelling in the domain of high-performance liquid chromatography (HPLC). Currently, there are no standardized methods for selecting MDs, and there is a general lack of understanding about their impact on chromatography, which is more challenging given the multitude of available descriptors. This review aims to provide a comprehensive overview of the role of feature selection methods and an aid for the reader to navigate through MDs in the field of HPLC. It critically assesses the advantages and limitations of the methodologies used since the understanding of more advanced machine learning models. Furthermore, it evaluates the most influential MDs in HPLC and their relationship to retention time, advocating for pursuing innovative descriptor research, using cutting-edge approaches, and interdisciplinary collaboration to surmount challenges and enhance the quality of predictive models in the field of liquid chromatography.

引用次数: 0

Comparing hydrogen-bonded organic frameworks and metal-organic frameworks for biosensor applications

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-24 DOI: 10.1016/j.trac.2025.118211

Navid Rabiee

This paper presents a comparative perspective on the use of hydrogen-bonded organic frameworks (HOFs) and metal-organic frameworks (MOFs) in the development of biosensors. Both HOFs and MOFs have gained significant attention due to their tunable structures, high surface areas, and potential for a wide range of applications, including environmental monitoring, medical diagnostics, and biosensing. HOFs, with their non-metallic nature and reliance on hydrogen bonds, offer unique advantages such as easier synthesis, biocompatibility, and enhanced stability in certain environments. In contrast, MOFs, which incorporate metal centers, exhibit superior mechanical strength, higher stability, and versatility in sensing a broader range of analytes. This paper reviews the key features, advantages, and limitations of HOFs and MOFs in the context of biosensor development. It highlights recent advancements in their applications for detecting biological targets, and exploring their sensitivity, selectivity, and response times. Additionally, the paper discusses the challenges in integrating these materials into functional biosensors and provides insights into their future potential for improving diagnostic tools, environmental monitoring, and healthcare applications. Also, the paper offers a critical evaluation of how HOFs and MOFs can complement each other in advancing biosensor technology.

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引用次数: 0

Smart polymers advance analytical chemistry

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-22 DOI: 10.1016/j.trac.2025.118198

Yahui Zhang , Xinjia Zhao , Guangyan Qing

The “precision medicine” project put forward higher requirements for analytical chemistry, centering on new material development. Given the increasing diversity of complex samples and rising demands on analytical methods, breakthroughs in the creation of analytical materials that offer selectivity, sensitivity, speed, and specificity are required. As a star system in material science, smart polymers can respond to subtle changes in external stimuli, leading to significant conformational changes in their polymer chains, and further translating, transferring, and amplifying the stimulus signals into macroscopic properties of the material. Their excellent controllability and adjustability in both structures and functions inject fresh energy into the advancement of analytic methods. This review concisely presents the latest research regarding the advancements of smart polymers in analytical chemistry, and furthermore proposes the challenges and feasible solutions that smart polymers encounter during design and application. These materials will accelerate the arrival of a new era of precision medicine.

引用次数: 0

Corrigendum to “Multidimensional single-cell analysis: Diverse strategies and emerging applications in the life sciences” [TrAC Trends Anal. Chem. 185 (2025) 118170]

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-22 DOI: 10.1016/j.trac.2025.118197

Boyang Zhang , Xinyue Lan , Siyuan Tan , Zehu Xie , Longjiao Zhu , Xiaoyun Gong , Xinhua Dai , Xiang Fang , Wentao Xu

引用次数: 0

Methods for sample pretreatment and detection of per- and polyfluoroalkyl substances in biological samples: A review

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-21 DOI: 10.1016/j.trac.2025.118206

Yuanxing Liu, Wenmei Zhang, Guizhen Zhu, Tong Pei, Guangsheng Guo, Xiayan Wang, Yaoyao Zhao

Per- and polyfluoroalkyl substances (PFAS) are a class of persistent organic pollutants that exhibit various transmission routes, ubiquity in the environment and human body, and toxicity to organisms. Accurately analyzing the types and concentrations of PFAS in organisms, along with their health impacts, has become a significant public concern. The primary challenge in detecting PFAS in biological samples is the complexity of the samples. Therefore, a sample pre-treatment procedure is commonly required before the analysis of biological samples. This review summarizes the latest advancements in the instrumental detection methods for PFAS in biological samples over the past five years, with a specific focus on technical aspects including sample pre-treatment strategies. Additionally, it provides a brief outlook on the future development trends of these methods.

引用次数: 0

Corrigendum to “Harnessing CRISPR technology for next-generation microphysiological systems” [Trends Anal. Chem. 185 (2025) 118164]

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-21 DOI: 10.1016/j.trac.2025.118192

Sojin Song , Hyun Wook Kang , Minjin Kang , Seok Chung , Nakwon Choi , Hong Nam Kim , Young Joon Sung

引用次数: 0

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