Advances of signal amplification strategies and sensing formats in electrochemiluminescence sensors for mycotoxins

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL Trends in Analytical Chemistry Pub Date : 2024-09-07 DOI:10.1016/j.trac.2024.117961

Tingting Han , Chen Cui , Yujun Xing , Jianrong Shi , Jianhong Xu , Jun-Jie Zhu

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Abstract

Mycotoxins are toxic secondary metabolites produced by fungus, which has carcinogenicity, teratogenicity, mutagenicity, and immunotoxicity, posing a serious hazard to food safety and public health. Therefore, it is of great importance to exploit rapid, sensitive, and universal analytical methods for mycotoxins detection to safeguard food safety and public health. Electrochemiluminescence (ECL) has been regarded as a promising analytical technology for monitoring mycotoxins in foods due to zero background and high sensitivity. Signal amplification strategies take vital roles in developing advanced ECL biosensors with high sensitiveness. Besides, deep insights into sensing formats and patterns will favour in designing innovative ECL sensors. In this review, the latest developments in various ECL sensors for mycotoxins assays are summarized, with emphasis on signal enhancement strategies and sensing formats in their applications. The opportunities and challenges are also discussed in the development and application of advanced ECL sensors for mycotoxins analysis.

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霉菌毒素电化学发光传感器的信号放大策略和传感形式的进展

霉菌毒素是真菌产生的有毒次级代谢产物，具有致癌性、致畸性、致突变性和免疫毒性，严重危害食品安全和公众健康。因此，利用快速、灵敏、通用的分析方法检测霉菌毒素对保障食品安全和公众健康具有重要意义。电化学发光（ECL）具有零本底和高灵敏度的特点，被认为是监测食品中霉菌毒素的一种有前途的分析技术。信号放大策略在开发具有高灵敏度的先进 ECL 生物传感器中发挥着至关重要的作用。此外，对传感形式和模式的深入了解将有助于设计创新型 ECL 传感器。本综述总结了用于霉菌毒素检测的各种 ECL 传感器的最新发展，重点介绍了其应用中的信号增强策略和传感形式。此外，还讨论了开发和应用先进的 ECL 传感器进行霉菌毒素分析所面临的机遇和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.