Investigating the effect of adding P2O5 on bioactivity and magnetic properties of self-regulating temperature glass ceramics

Abstract

Magnetic fluid hyperthermia (MFH) is one of the new methods for personalizing cancer treatment. In this study, ${20\text{SiO}}_2‐50\text{FeO}‐15\text{CaO}‐15{\text{Na}}_{2}O$ glass ceramics was selected as the base glass and the effect of adding different $P_2{O}_5$ percentages on the magnetic properties and bioactivity of the samples were investigated. Phase studies showed that maghemite, hematite, sodium calcium silicate, and iron calcium silicate phases have crystallized in glass ceramics. Structural studies showed that $P_2{O}_5$ acted as a nucleation agent in glass ceramics and reduced the size of maghemite and hematite crystals. By increasing $P_2{O}_5$ to 2 wt%, the magnetic saturation of the samples increased to 22.5emu/g and decreased in higher percentages. The highest increase in temperature also belonged to these samples, and its value was measured as 13 $°C$. Study the samples immersed in the simulated body fluid (SBF), it was seen that hydroxyapatite with cauliflower morphology was crystallized on the surface of the samples.