Phenylboronic acid-functionalized biomaterials for improved cancer immunotherapy via sialic acid targeting

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2024-09-06 DOI:10.1016/j.cis.2024.103301

Ashok Kumar Jangid, Kyobum Kim

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Abstract

Phenylboronic acid (PBA) is recognized as one of the most promising cancer cell binding modules attributed to its potential to form reversible and dynamic boronic ester covalent bonds. Exploring the advanced chemical versatility of PBA is crucial for developing new anticancer therapeutics. The presence of a specific Lewis acidic boron atom-based functional group and a Π-ring-connected ring has garnered increasing interest in the field of cancer immunotherapy. PBA-derivatized functional biomaterials can form reversible bonds with diols containing cell surface markers and proteins. This review primarily focuses on the following topics: (1) the importance and versatility of PBA, (2) different PBA derivatives with pKa values, (3) specific key features of PBA-mediated biomaterials, and (4) cell surface activity for cancer immunotherapy applications. Specific key features of PBA-mediated materials, including sensing, bioadhesion, and gelation, along with important synthesis strategies, are highlighted. The utilization of PBA-mediated biomaterials for cancer immunotherapy, especially the role of PBA-based nanoparticles and PBA-mediated cell-based therapeutics, is also discussed. Finally, a perspective on future research based on PBA-biomaterials for immunotherapy applications is presented.

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苯硼酸功能化生物材料通过硅唾液酸靶向改善癌症免疫疗法

苯硼酸（PBA）具有形成可逆动态硼酸酯共价键的潜力，因此被认为是最有前途的癌细胞结合模块之一。探索 PBA 的高级化学多功能性对于开发新的抗癌疗法至关重要。基于硼原子的特定路易斯酸官能团和Π-环连接环的存在在癌症免疫疗法领域引起了越来越多的兴趣。PBA 衍生功能生物材料可与含有细胞表面标记物和蛋白质的二元醇形成可逆键。本综述主要关注以下主题：(1) PBA 的重要性和多功能性，(2) 不同 PBA 衍生物的 pKa 值，(3) PBA 介导的生物材料的具体关键特征，以及 (4) 用于癌症免疫疗法的细胞表面活性。重点介绍了 PBA 介导材料的具体关键特征，包括传感、生物粘附和凝胶化，以及重要的合成策略。此外，还讨论了将 PBA 介导的生物材料用于癌症免疫疗法的问题，特别是基于 PBA 的纳米粒子和 PBA 介导的细胞疗法的作用。最后，展望了基于 PBA 生物材料的免疫疗法应用的未来研究。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.