The mechanism of action and chemical synthesis of FDA newly approved drug molecules

IF 3.5 4区 医学 Q2 CHEMISTRY, MEDICINAL Drug Development Research Pub Date : 2024-09-10 DOI:10.1002/ddr.22260
Dan-Dan Shen, Yue-Lin Zhang, Xiang Li, Yi-Ru Bai, Jun-Feng Xiong, Dong-Jie Seng, Yao-Dong Zhang, Hong-Min Liu, Shuo Yuan, Li Yang
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Abstract

In 2023, the U.S. Food and Drug Administration has approved 29 small molecule drugs. These newly approved small molecule drugs possess the distinct scaffolds, thereby exhibiting diverse mechanisms of action and binding modalities. Moreover, the marketed drugs have always been an important source of new drug development and creative inspiration, thereby fostering analogous endeavors in drug discovery that potentially extend to the diverse clinical indications. Therefore, conducting a comprehensive evaluation of drug approval experience and associated information will facilitate the expedited identification of highly potent drug molecules. In this review, we comprehensively summarized the relevant information regarding the clinical applications, mechanisms of action and chemical synthesis of 29 small molecule drugs, with the aim of providing a promising structural basis and design inspiration for pharmaceutical chemists.

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FDA 新批准药物分子的作用机制和化学合成
2023 年,美国食品和药物管理局批准了 29 种小分子药物。这些新批准的小分子药物拥有不同的支架,因此表现出不同的作用机制和结合方式。此外,已上市药物一直是新药开发和创新灵感的重要来源,从而促进了药物发现的类似努力,并有可能扩展到不同的临床适应症。因此,对药物审批经验和相关信息进行全面评估将有助于加快高效药物分子的发现。在这篇综述中,我们全面总结了 29 种小分子药物的临床应用、作用机制和化学合成等相关信息,旨在为药物化学家提供有前景的结构基础和设计灵感。
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来源期刊
CiteScore
6.40
自引率
2.60%
发文量
104
审稿时长
6-12 weeks
期刊介绍: Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
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