Type 1 diabetes, celiac disease, and autoimmune thyroiditis autoantibodies in population-based type 2 diabetes patients

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM Journal of Clinical and Translational Endocrinology Pub Date : 2024-09-01 DOI:10.1016/j.jcte.2024.100367
Lind Alexander , Tsai Cheng-ting , Lernmark Åke , Jendle Johan
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Abstract

Aims

The study aims were to determine autoantibodies associated with type 1 diabetes (T1D), celiac disease (CD) and autoimmune thyroid disease (AITD) in individuals living with type 2 diabetes (T2D) compared to T1D and matched controls.

Methods

Individuals with T1D and T2D were randomly identified in health-care registers. Blood was collected through home-capillary sampling and autoantibodies associated with either T1D against glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A), CD against tissue transglutaminase (tTGA) or AITD against thyroid peroxidase (TPOA) were determined in an automated, multiplex Antibody Detection by Agglutination-PCR (ADAP) assay.

Results

GADA were detected in 46 % (88/191) of T1D and increased to 6.2 % (23/372) in T2D compared to 2.6 % (7/259) of controls (p = 0.0367). tTGA was low (1.1–2.6 %) and not different in between the study cohorts, nonetheless, in T1D tTGA was associated to islet autoantibodies. TPOA was more frequent in T1D, 27.1 % (53/191), compared to either T2D, 14.8 % (55/372; p = 0.0002) or controls, 14.3 % (37/259) (p = 0.0004). Overall, TPOA was more frequent in GADA positive (34.8 %; 8/23) than negative (13.5 %; 47/349; p = 0.0053) T2D individuals.

Conclusion

It’s suggested that analyzing GADA and TPOA may refine the autoimmune landscape in individuals clinically classified as T2D.

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人群中 2 型糖尿病患者的 1 型糖尿病、乳糜泻和自身免疫性甲状腺炎自身抗体
研究目的是确定与1型糖尿病(T1D)、乳糜泻(CD)和自身免疫性甲状腺疾病(AITD)相关的自身抗体,并与2型糖尿病(T2D)患者和T1D及匹配对照组进行比较。通过家庭毛细管采样收集血液,并通过凝集-PCR(ADAP)自动多重抗体检测法测定与 T1D 有关的谷氨酸脱羧酶(GADA)、胰岛素(IAA)、胰岛素瘤抗原-2(IA-2A)和锌转运体 8(ZnT8A)自身抗体,与组织转谷氨酰胺酶(tTGA)有关的 CD 自身抗体,或与甲状腺过氧化物酶(TPOA)有关的 AITD 自身抗体。结果在46%的T1D患者(88/191)中检测到了甲状腺自身抗体,在T2D患者中检测到的甲状腺自身抗体增加到了6.2%(23/372),而在对照组中检测到的甲状腺自身抗体仅为2.6%(7/259)(p = 0.0367)。TPOA在T1D中更为常见,占27.1%(53/191),而在T2D中为14.8%(55/372;p = 0.0002),在对照组中为14.3%(37/259)(p = 0.0004)。总的来说,GADA 阳性(34.8%;8/23)的 TPOA 发生率高于阴性(13.5%;47/349;p = 0.0053)的 T2D 患者。
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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
24
审稿时长
16 weeks
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