In silico analysis of LPMO inhibition by ethylene precursor ACCA to combat potato late blight

Abstract

Potato late blight (PLB), caused by the pathogen Phytophthora infestans, severely threatens potato production worldwide. This study investigates the potential of the ethylene precursor 1-amino-cyclopropane-1-carboxylic acid (ACCA) to inhibit Lytic Polysaccharide Monooxygenases (LPMOs) in P. infestans, a key protein involved in the disease’s pathogenesis. Our findings demonstrate that ACCA significantly enhances the immune response in potato plants against P. infestans, with a binding energy of −8.85 kcal/mol. Integrating ACCA treatment into existing PLB management strategies could offer a novel and sustainable approach to combat this devastating disease. This research provides valuable insights into reducing the global impact of PLB and improving food security through innovative control measures.