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An inertial conjugate gradient projection method for large-scale nonlinear equations and its application in the image restoration problems 大规模非线性方程的惯性共轭梯度投影法及其在图像恢复问题中的应用
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103547
Gonglin Yuan , Chunzhao Liang , Yong Li
Based on the acceleration effect of the inertial extrapolation technique on the convergence of iterative sequences, the number of algorithms incorporating this technique has gradually increased in recent years. Currently, there is a relative paucity of studies focusing on the Polak-Ribière-Polyak (PRP) conjugate gradient algorithm that integrate the inertial extrapolation technique. In this article, we introduce an inertial three-term PRP conjugate gradient projection method by incorporating an inertial extrapolation step into the three-term PRP algorithm, where the search direction exhibits sufficient descent and trust region characteristics. The search rule employs a derivative-free technique. Under suitable hypotheses, the proposed algorithm demonstrates global convergence. Numerical results indicate the superiority and competitiveness of this innovative method. Furthermore, its effectiveness in addressing image restoration problems underscores the practicality of this algorithm.
基于惯性外推技术对迭代序列收敛的加速效应,近年来采用该技术的算法逐渐增多。目前,针对结合惯性外推技术的polak - ribi - polyak (PRP)共轭梯度算法的研究相对较少。本文通过在三项PRP算法中加入惯性外推步骤,提出了一种惯性三项PRP共轭梯度投影方法,该方法的搜索方向具有足够的下降和信赖域特征。搜索规则采用无导数技术。在适当的假设条件下,该算法具有全局收敛性。数值结果表明了该方法的优越性和竞争力。此外,它在解决图像恢复问题上的有效性突出了该算法的实用性。
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引用次数: 0
Advanced thermal management system of Lithium-Ion Batteries: Integrating thermoelectric modules with phase change materials 先进的锂离子电池热管理系统:热电模块与相变材料的集成
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103570
Mohammed A. Alghassab
This study investigates an innovative approach to lithium-ion battery thermal management using thermoelectric (TEC) modules and phase change materials (PCMs). The system incorporates battery enclosures filled with PCMs to stabilize temperature fluctuations. These enclosures are immersed in a water reservoir where the heat from the batteries is absorbed by the PCMs, which subsequently transfer heat to the surrounding water. A TEC cooling system then cools the water, completing the heat dissipation cycle. Experimental results show that this integrated system effectively reduces battery temperatures, achieving temperature reductions of approximately 12% for 50-watt, 9% for 30-watt, and 14% for 10-watt battery modes compared to natural convection methods. This approach not only enhances battery performance but also proves suitable for applications requiring compact and efficient thermal management solutions, such as electric vehicles.
本研究探讨了一种利用热电(TEC)模块和相变材料(pcm)进行锂离子电池热管理的创新方法。该系统包含充满pcm的电池外壳,以稳定温度波动。这些外壳浸泡在水箱中,电池的热量被pcm吸收,pcm随后将热量传递给周围的水。然后,TEC冷却系统冷却水,完成散热循环。实验结果表明,该集成系统有效地降低了电池温度,与自然对流方法相比,50瓦电池模式的温度降低了约12%,30瓦电池模式的温度降低了9%,10瓦电池模式的温度降低了14%。这种方法不仅提高了电池性能,而且适用于需要紧凑高效热管理解决方案的应用,例如电动汽车。
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引用次数: 0
Sensitivity analysis and application of single-valued neutrosophic transportaion problem 单值嗜中性粒细胞转运问题的敏感性分析及应用
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103567
M. Kanchana, K. Kavitha
The neutrosophic set serves as a powerful tool for addressing complexity, ambiguity, and managing imperfect and inconsistent information in the digital world. Graph theory plays a crucial role in determining the shortest path for neutrosophic sets through graph algorithms. This article introduces a novel algorithm, the bipartite graph contraction algorithm, to elucidate the graphical aspects within neutrosophic set theory by using score function for ranking. The proposed bipartite neutrosophic graph contraction algorithm is applied to solve a single-valued neutrosophic network, where the transportation unit cost is expressed as a trapezoidal single-valued neutrosophic number and produced the result as 364,537,694,908;0.3,0.7,0.7. A comparative analysis with an existing algorithm is conducted, and a novel introduction of sensitivity analysis in the realm of neutrosophic set theory is presented to assess the optimality of the result in neutrosophic transportation problems.
嗜中性集是解决数字世界中复杂性、模糊性和管理不完善和不一致信息的有力工具。图论在通过图算法确定嗜中性集合的最短路径方面起着至关重要的作用。本文介绍了一种新颖的算法——二部图收缩算法,利用分数函数进行排序来阐明中性集理论中的图形方面。将提出的二部嗜中性图收缩算法应用于求解单值嗜中性网络,将运输单位成本表示为梯形的单值嗜中性数,得到的结果为< 364,537,694,908;0.3,0.7,0.7 >。与现有算法进行了比较分析,并在中性粒细胞集合理论领域引入敏感性分析,以评估中性粒细胞运输问题结果的最优性。
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引用次数: 0
Antioxidant activities of seeds and sprouts of Momordica charantia and their antibacterial efficacies against pathogenic bacteria isolated from hospitalized patients 苦瓜种子和芽的抗氧化活性及其对住院患者病原菌的抑菌作用
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103580
Md. Shihab Uddin Sohag, Md. Al-Monsur, Md. Mushfiqur Rahman, Md. Al Amin Sarker, Sanjay Dutta, Fazle Rabbi Shakil Ahmed
During sprouting, significant chemical transformations frequently transpire, leading to variations in the concentrations of diverse bioactive compounds present in the seeds. Consequently, seeds and sprouts may have altered bioactivity. The current study aimed to evaluate the in vitro antioxidant activities of crude hydroalcoholic (70 % ethanol and 30 % distilled water) extracts of Momordica charantia seeds and sprouts and their antibacterial efficacies against morbific bacteria sourced from hospitalized patients. Utilizing three assays- DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), and ferric ions reducing power), the antioxidant activities were evaluated. The results revealed that the sprout extract significantly outperformed the seed extract in terms of Fe3+ ions reducing power, DPPH radical scavenging activity (IC50 = 163.37 ± 23.91 μg/ml), and ABTS radical scavenging activity (IC50 = 30.56 ± 6.90 µg/ml). The antibacterial efficacies against five morbific bacteria (Enterobacter cloacae, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella oxytoca) isolated from hospitalized patients were evaluated by the agar disc diffusion method. The findings indicated that the extracts derived from both sprouts and seeds exerted potent antibacterial efficacy by suppressing the growth of several clinical isolates. Both extracts possessed statistically significant (p < 0.05) antibacterial activity against Enterobacter cloacae and Escherichia coli. Seed extract had greater antibacterial activity than sprout extract against Enterococcus faecalis. Pseudomonas aeruginosa exhibited the lowest and identical susceptibility at three distinct concentrations (200 μg, 400 μg, and 800 μg) of seed extract. No extracts have shown any antibacterial action against Klebsiella oxytoca. The results of the study indicate that Momordica charantia sprouts exhibit a greater capacity to scavenge free radicals as antioxidants, whereas seeds possess more potent and broader antibacterial efficacy compared to sprouts.
在发芽过程中,重要的化学转化经常发生,导致种子中存在的各种生物活性化合物浓度的变化。因此,种子和芽可能已经改变了生物活性。本研究旨在评价苦瓜种子和芽的粗水醇(70%乙醇和30%蒸馏水)提取物的体外抗氧化活性及其对住院病人病原菌的抗菌作用。采用DPPH(2,2-二苯基-1-吡啶肼基)、ABTS(2,2 ' -氮基-双(3-乙基苯并噻唑-6-磺酸)和铁离子还原力)3种测定方法对其抗氧化活性进行了评价。结果表明,豆芽提取物对Fe3+离子还原能力、DPPH自由基清除能力(IC50 = 163.37±23.91 μg/ml)和ABTS自由基清除能力(IC50 = 30.56±6.90µg/ml)均显著优于种子提取物。采用琼脂盘扩散法对住院患者分离的5种致病菌(阴沟肠杆菌、大肠杆菌、粪肠球菌、铜绿假单胞菌和氧化克雷伯菌)进行抑菌效果评价。结果表明,从芽和种子中提取的提取物可以抑制几种临床分离株的生长,具有较强的抗菌作用。两种提取物均具有统计学意义(p <;0.05)对阴沟肠杆菌和大肠杆菌的抑菌活性。种子提取物对粪肠球菌的抑菌活性高于芽提取物。铜绿假单胞菌在不同浓度(200 μg、400 μg和800 μg)的种子提取物中表现出最低且相同的敏感性。没有提取物显示出任何抗菌作用对克雷伯氏菌。研究结果表明,苦瓜芽作为抗氧化剂具有更强的清除自由基的能力,而种子具有比豆芽更强、更广泛的抗菌功效。
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引用次数: 0
Anti-inflammatory potential of aloe vera meatballs and their impact on rheumatoid arthritis 芦荟肉丸的抗炎潜能及其对类风湿关节炎的影响
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103573
Warda Khan , Rizwan Shaukat , Awais Khan , Amna Khan , Bushra Ahmad , Saira Saleem , Mohammad Abul Farah , Waqas Amin , Obaid Ullah Khan
Rheumatoid Arthritis is an auto-immune condition resulting in the formation of autoantibodies that cause joint and systemic inflammation. Different signs and symptoms include pain, redness, and swelling in joints leading to difficulties performing day-to-day activities and restlessness. The prevalence of Rheumatoid Arthritis worldwide and in Pakistan is 0.5 % and 1 %, respectively, with females experiencing a higher ratio due to improper diet, weight loss, fatigue, and housework. Aloe vera chicken meatballs, rich in protein, calories, phenolic compounds, polysaccharides, and collagen protein, have anti-inflammatory effects on arthritis patients by reducing inflammatory mediator production. By considering this, we conducted an experiment on the production of Aloe Vera based chicken meatballs with different doses including (100 g of chicken, 10 g of Aloe Vera + 90 g of Chicken, 20 g of Aloe Vera + 80 g of Chicken, 30 g of Aloe Vera + 70 g of Chicken) at Meat Science Nutraceutical Laboratory, National Institute of Food Science and Technology, University of Agriculture, Faisalabad. 100 g of chicken was considered as a control treatment. The meatballs were tested on four different groups of rheumatoid patients at Allied Hospital Faisalabad. The results indicated that the combination (20 g of Aloe Vera + 80 g of Chicken) yielded the most significant reduction in the Arthritis Factor Test by 26 %, compared to untreated arthritis patients. Additionally, it showed 20 % higher acceptability than the control group. Therefore, meatballs containing 20 g of Aloe Vera and 80 g of Chicken were deemed the most effective biomedicine for alleviating rheumatoid arthritis in humans.
类风湿关节炎是一种自身免疫疾病,导致自身抗体的形成,引起关节和全身炎症。不同的体征和症状包括关节疼痛、发红和肿胀,导致日常活动困难和不安。全球和巴基斯坦的类风湿性关节炎患病率分别为0.5%和1%,由于饮食不当、体重减轻、疲劳和家务劳动,女性的患病率更高。芦荟鸡肉丸富含蛋白质、卡路里、酚类化合物、多糖和胶原蛋白,通过减少炎症介质的产生对关节炎患者有抗炎作用。考虑到这一点,我们在费萨拉巴德农业大学国家食品科学与技术研究所肉类科学营养实验室进行了不同剂量(100 g鸡肉,10 g芦荟+ 90 g鸡肉,20 g芦荟+ 80 g鸡肉,30 g芦荟+ 70 g鸡肉)的芦荟鸡肉丸生产实验,以100 g鸡肉为对照处理。这些肉丸在费萨拉巴德联合医院的四组不同的类风湿患者身上进行了测试。结果表明,与未经治疗的关节炎患者相比,这种组合(20克芦荟+ 80克鸡肉)在关节炎因子测试中产生了26%的显著降低。此外,它的可接受性比对照组高20%。因此,含有20克芦荟和80克鸡肉的肉丸被认为是缓解人类类风湿关节炎最有效的生物医药。
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引用次数: 0
Copper and chromium binding by Pseudomonas aeruginosa strain PA01 for implications of heavy metal detoxification and soil remediation: A computational approach 铜绿假单胞菌菌株PA01结合铜和铬对重金属解毒和土壤修复的影响:计算方法
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103552
Shanmuga Priya Ramasamy , Priya Sundararajan , Muthukrishnan Pallikondaperumal , Ponmurugan Karuppiah , Saminathan Kayarohanam , Natarajan Arumugam , Ling Shing Wong , Sinouvassane Djearamane
Heavy metal pollution poses significant environmental and health risks due to the toxic effects of metals like copper and chromium at elevated concentrations. Despite their essential roles in trace amounts, these metals can be highly toxic. Bacteria such as Pseudomonas aeruginosa are promising candidates for bioremediation due to their robustness and adaptability. The objective of this study was to analyze and identify potential copper and chromium binding genes involved in metal detoxification in Pseudomonas aeruginosa PA01. The heavy metal binding protein identified as ferredoxin using MALDI-TOF/PMF-MS analysis was further characterized. The structure of the ferredoxin protein was elucidated using the SWISS-MODEL tool. Metal-binding domains were validated through a pattern search against UniProtKB/Swiss-Prot and UniProtKB/TrEMBL databases using the ScanProsite tool. Comparative sequence alignments were conducted between the copper-binding NosD gene of P. aeruginosa, the ferredoxin gene of P. aeruginosa PA01, and the chromium-binding iron hydrogenase 1 gene of Clostridium chromiireducens. The SWISS-MODEL analysis revealed alpha helices and beta sheets with key metal-coordinating amino acids (cysteine, glutamic acid, aspartic acid, histidine, and methionine). The ScanProsite tool confirmed the presence of a 4Fe-4S ferredoxin-type iron-sulphur binding domain essential for coordinating chromium and copper ions. Sequence alignments showed a 64.29 % similarity between the NosD gene and ferredoxin gene, and a 67 % identity between the iron hydrogenase 1 gene and ferredoxin gene, with correlations in amino acid residues involved in metal binding. These findings suggest that the ferredoxin gene could effectively bind heavy metal ions, offering potential applications in bioremediation of metal-polluted soils using Pseudomonas species. This study contributes to sustainable agricultural productivity by facilitating the targeted remediation of heavy metal-contaminated soils through biological means.
由于铜和铬等金属在浓度升高时的毒性作用,重金属污染对环境和健康构成重大风险。尽管这些微量金属具有重要作用,但它们可能具有剧毒。铜绿假单胞菌等细菌由于其稳健性和适应性而成为生物修复的有希望的候选者。本研究的目的是分析和鉴定铜绿假单胞菌PA01中参与金属解毒的潜在铜和铬结合基因。利用MALDI-TOF/PMF-MS进一步鉴定重金属结合蛋白为铁氧还蛋白。利用SWISS-MODEL工具分析了铁氧还蛋白的结构。通过使用ScanProsite工具对UniProtKB/Swiss-Prot和UniProtKB/TrEMBL数据库进行模式搜索来验证金属结合结构域。对铜绿假单胞菌铜结合NosD基因、铜绿假单胞菌PA01铁氧还蛋白基因和铬还原梭菌铁结合氢化酶1基因进行了比较序列比对。SWISS-MODEL分析显示α螺旋和β薄片具有关键的金属配位氨基酸(半胱氨酸、谷氨酸、天冬氨酸、组氨酸和蛋氨酸)。ScanProsite工具证实了4Fe-4S铁还原蛋白型铁硫结合域的存在,这对铬和铜离子的配位至关重要。序列比对显示,NosD基因与铁氧还蛋白基因的相似性为64.29%,铁氢化酶1基因与铁氧还蛋白基因的相似性为67%,且与金属结合相关的氨基酸残基存在相关性。这些发现表明,铁氧还蛋白基因可以有效结合重金属离子,在利用假单胞菌修复金属污染土壤方面具有潜在的应用前景。该研究有助于通过生物手段对重金属污染土壤进行有针对性的修复,从而促进农业生产力的可持续发展。
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引用次数: 0
Assessment of wind potential energy of four major cities in Cote d’ivoire using satellite data from 2015 to 2022 2015 - 2022年科特迪瓦四个主要城市风电潜力卫星数据评估
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103579
Daouda Kone , Souleymane Tuo , Kolotioloma Alama Coulibaly , Bi Tra Olivier Gore , Kouakou Bernard Dje , Mariam Traore , Boko Aka
In Côte d’Ivoire, the use of renewable energy is becoming a major challenge in the context of climate change and global warming. Therefore, the aim of this study is to characterize the wind profile for potential energy in Abidjan, Man, Bouaké and Korhogo of Côte d’Ivoire using satellite data. Wind speed and direction data from Copernicus Centre from 2015 to 2022 are used for these major cities. The frequency method is used to build wind rose and power density formula to estimate the potential energy for each city, at ground level (10 m) and in particular level at 100 m and 500 m. The results showed a slightly wind speed and direction variation from 2015 to 2022. This suggests that wind has a seasonal (wet and dry) evolution over the year. However, wind speeds increase for each city with the altitude. The higher average wind speed is observed in Abidjan with a power density of 58 W/m2. The lower wind speed and power density are observed in Man, Bouaké and Korhogo. So, the coastline of Côte d’Ivoire has the higher wind energy resource than the inland regions of the country.
在Côte科特迪瓦,可再生能源的使用正在成为气候变化和全球变暖背景下的一项重大挑战。因此,本研究的目的是利用卫星数据表征科特迪瓦阿比让、曼、布瓦克瓦伊和科霍戈的潜在能量风廓线。哥白尼中心2015年至2022年的风速和风向数据用于这些主要城市。利用频率法建立风升和功率密度公式,估算各城市、地面(10 m)、特别是100 m和500 m的位能。结果显示,从2015年到2022年,风速和风向略有变化。这表明风在一年中有季节性(干湿)的变化。然而,风速随着海拔的升高而增加。在阿比让观测到较高的平均风速,功率密度为58 W/m2。曼、布瓦克维尔和科霍戈的风速和功率密度较低。因此,Côte科特迪瓦的海岸线比该国内陆地区拥有更高的风能资源。
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引用次数: 0
Genetic and haplotype diversity of redbreast tilapia (Coptodon rendalli) based on cytochrome oxidase subunit I and D-loop 基于细胞色素氧化酶I亚基和d环的红胸罗非鱼遗传多样性和单倍型多样性
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103585
Mehrnoush Aminisarteshnizi, Ngonidzashe A.G. Moyo, Mokgadi E. Raphalo
The genetic diversity in Redbreast tilapia (Coptodon rendalli) is under threat from climate change, human activities, and natural hybridisation, prompting conservation concerns. To investigate the genetic characteristics of C. rendalli, genetic diversity, genetic structure, population differentiation, and historical demography were evaluated using mitochondrial DNA COI (cytochrome oxidase subunit I) and D-loop sequences from various countries. Phylogenetic and genetic diversity analysis based on the mtDNA sequences (COI H = 9, haplogroup = 3, and D-loop H = 5, haplogroup = 3) showed private haplotypes in some of the populations. The results showed significant differences in genetic diversity among the analysed populations (P < 0.001). Molecular variance analysis showed low variation levels among populations (COIFST = 0.02176, D-loopFST = 0.52), which was significant only for D-loop. The neutrality tests and mismatch distribution based on the mtDNA supported the hypothesis of under-purifying selection of C. rendalli. The results indicated that the population did not undergo expansion. The findings of this study revealed molecular divergence among the C. rendalli populations and may serve as pivot information for the genetic improvement of this species. In conclusion, this study has elucidated the utility of two reliable and cost-effective molecular markers for analysing genetic diversity. Notably, the mitochondrial D-loop region’s sensitivity to reflecting genetic diversity in C. rendalli surpasses that of the COI gene.
红胸罗非鱼(Coptodon rendalli)的遗传多样性受到气候变化、人类活动和自然杂交的威胁,引起了人们对其保护的关注。为了研究黄颡鱼的遗传特征,利用来自不同国家的线粒体DNA COI(细胞色素氧化酶亚基I)和d环序列,对黄颡鱼的遗传多样性、遗传结构、种群分化和历史人口统计学进行了评估。基于mtDNA序列(COI H = 9, haplogroup = 3, D-loop H = 5, haplogroup = 3)的系统发育和遗传多样性分析显示,部分群体存在私有单倍型。结果显示,所分析群体间遗传多样性存在显著差异(P <;0.001)。分子方差分析显示群体间COIFST = 0.02176, D-loopFST = 0.52,差异不显著,仅D-loop差异显著。基于mtDNA的中性性检验和错配分布支持了青霉的低净化选择假说。结果表明,种群未发生扩张。本研究的结果揭示了青檀居群间的分子分化,可作为青檀遗传改良的支点信息。总之,本研究阐明了两种可靠且经济的分子标记在遗传多样性分析中的应用。值得注意的是,C. rendalli线粒体D-loop区域对反映遗传多样性的敏感性超过了COI基因。
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引用次数: 0
Therapeutic potential of Chemogenic Iron oxide Nanoparticles, its antioxidant and anti-Inflammatory effects with reduction of ankle joint swelling in BALB/c mice 致化学氧化铁纳米颗粒的治疗潜力及其抗氧化和抗炎作用与减轻BALB/c小鼠踝关节肿胀
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103556
Mubin Mustafa Kiyani , Sarah Sadiq , Maria Sarfraz , Chanda Javed , Maisra Azhar Butt , Hassan Burair Abbas , Hamza Rehman , Syed Ali Imran Bokhari
Background: Gout is a form of inflammatory arthritis caused by excessive deposition of uric acid in the body and joints. Prolonged administration of uric acid lowering drugs have multiple side effects. Objectives: To investigate the antioxidant and anti-gout properties of iron oxide nanoparticles in hyperuricemic gouty mice. Methodology: Sol-Gel precipitation technique was used for chemogenesis of Iron oxide nanoparticles by using Ferrous Chloride (FeCl2) and Ferric chloride (FeCl3). Characterization was carried out by X-ray diffraction, SQUID magnetization, scanning electron microscopy(SEM) and energy-dispersive X-ray spectroscopy(EDX). Monosodium Urate crystals (MSUC) induced gout into the ankle joint of the mice. Iron oxide nanoparticles were orally administrated to the mice. To study the impact of Iron oxide nanoparticles biochemical analysis like total protein, antioxidant activity, and ankle diameter were conducted. Results: Results showed that oral administration of iron oxide nanoparticles had a beneficiary impact on gouty mice. The antioxidant activity were significantly improved by increasing levels of thiobarbituric acid reactive substance and reactive oxygen species in treated group with 250 mg/kg of body weight of iron oxide nanoparticles. Ankle diameter and levels of total protein were also reduced in treated groups. Conclusion: Current research indicates that Iron oxide nanoparticles have antioxidant as well as anti-gout effects in gouty mice. These results provide credence to the possibility of using Iron oxide nanoparticles as a gout alternative treatment. The potential therapeutic uses of iron oxide nanoparticles in human patients require more investigation.
背景:痛风是一种炎症性关节炎的形式,引起过多的尿酸沉积在身体和关节。长期服用降尿酸药物有多种副作用。目的:研究氧化铁纳米颗粒对高尿酸血症性痛风小鼠的抗氧化和抗痛风作用。方法:采用溶胶-凝胶沉淀法,采用氯化亚铁(FeCl2)和氯化铁(FeCl3)制备氧化铁纳米颗粒。通过x射线衍射、SQUID磁化、扫描电镜(SEM)和能量色散x射线能谱(EDX)对其进行了表征。尿酸钠晶体(MSUC)诱导小鼠踝关节痛风。小鼠口服氧化铁纳米颗粒。为了研究氧化铁纳米颗粒对小鼠总蛋白、抗氧化活性、踝部直径等生化指标的影响。结果:结果表明,口服氧化铁纳米颗粒对痛风小鼠有有益作用。在250 mg/kg体重的氧化铁纳米颗粒处理组中,通过增加硫代巴比妥酸活性物质和活性氧水平,显著提高了抗氧化活性。治疗组的踝关节直径和总蛋白水平也有所降低。结论:目前研究表明氧化铁纳米颗粒对痛风小鼠具有抗氧化和抗痛风作用。这些结果为使用氧化铁纳米颗粒作为痛风替代治疗的可能性提供了证据。氧化铁纳米颗粒在人类患者中的潜在治疗用途需要更多的研究。
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引用次数: 0
Ecological risk assessment and potential source of As, Cd, Co, and Ni in Al Qunfudhah seawater, Red Sea coast, Saudi Arabia 沙特阿拉伯红海沿岸Al qundudhah海水中As、Cd、Co和Ni的生态风险评价及潜在来源
IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-01 DOI: 10.1016/j.jksus.2024.103560
Khaled Al-Kahtany, Abdelbaset S. El-Sorogy, Talal Alharbi
The rapid economic expansion of the worldwide coastal settlements has resulted in the discharge of substantial amounts of heavy metals (HMs), posing a considerable risk to marine organisms. The present work aims to evaluate the HM contamination of seawater and determine their potential sources in Al Qunfudhah seawater, Red Sea coast utilizing contamination factor (CF), degree of contamination (Cd), modified contamination factor (mCd), heavy metal pollution index (HPI), and multivariate analysis. A total of twenty-nine samples of surface seawater were gathered and the analysis of HMs was conducted using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The average concentration of dissolved HMs follows the following order: As (5.83 μg/L) ˃ Ni (0.990 μg/L) ˃ Co (0.168 μg/L) ˃ Cd (0.090 μg/L). The average concentrations of As, Co, Ni, and Cd were below the maximum admissible concentration (MAC) set by the World Health Organization (WHO), as well as the criterion continuous concentration (CCC) and criterion maximum concentration (CMC) set by the environmental protection agency. This suggests that the levels of these substances are within the acceptable limits for protecting aquatic life, both in the short-term and long-term exposures. The results of the analysis for CF, Cd, mCd, and HPI suggested clean and uncontaminated seawater in most sites. Few individual samples obtained elevated values, which might be attributed to natural source, mostly from chemical weathering of rock forming minerals from the Arabian Shield, as well as agricultural and coastal activities.
世界范围内沿海住区经济的迅速扩张导致了大量重金属的排放,对海洋生物构成了相当大的危险。利用污染因子(CF)、污染度(Cd)、修正污染因子(mCd)、重金属污染指数(HPI)和多变量分析等方法,对红海沿岸Al qundudhah海水中的HM污染进行评价,确定其潜在污染源。采集29份表层海水样品,采用电感耦合等离子体质谱法(ICP-MS)对HMs进行分析。溶解HMs的平均浓度顺序为:As (5.83 μg/L)、Ni (0.990 μg/L)、Co (0.168 μg/L)、Cd (0.090 μg/L)。砷、钴、镍和镉的平均浓度均低于世界卫生组织(WHO)规定的最大允许浓度(MAC)和环境保护机构规定的标准连续浓度(CCC)和标准最大浓度(CMC)。这表明,无论是短期接触还是长期接触,这些物质的含量都在保护水生生物的可接受限度之内。CF、Cd、mCd和HPI分析结果表明,大部分站点的海水干净、未受污染。很少有个别样品获得较高的数值,这可能是由于自然来源,主要是由于阿拉伯地盾形成岩石的矿物的化学风化作用,以及农业和沿海活动。
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Journal of King Saud University - Science
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