Non-lethal biomarkers as promising tools for fish health assessment: In situ exposure to bifenthrin as a case study

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY Aquatic Toxicology Pub Date : 2024-09-05 DOI:10.1016/j.aquatox.2024.107083

Carla Bacchetta , Jimena Cazenave , Celeste Mora , Melina P. Michlig , María R. Repetti , Andrea S. Rossi

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Abstract

Non-lethal biomonitoring should provide an innovative approach to establish bioethical protocols for the management of both aquaculture and wild fisheries resources. We aimed to assess non-lethal biomarkers in Piaractus mesopotamicus caged in a rice field during a bifenthrin (BF) application. We analyzed parameters related to the immune system, energy metabolism and oxidative stress in fish skin mucus and blood plasma. Fish exposed to BF showed a significant increase in skin mucus glucose levels and the enzymatic activities of protease, alkaline phosphatase and superoxide dismutase. Regarding plasmatic parameters, BF increased the levels of glucose, total protein and albumin, but decreased triglycerides. In addition, increased activities of lysozyme and alkaline phosphatase were found in the blood plasma of exposed fish. Our results indicated an increased energy demand, altered immune function and a mild oxidative stress response in fish exposed in situ to BF. We have shown that skin mucus and blood plasma are very promising matrices for the development of non-lethal biomarkers to assess fish health in a stressed environment.

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非致命生物标志物是鱼类健康评估的有效工具：联苯菊酯原位暴露案例研究

非致死性生物监测应为制定水产养殖和野生渔业资源管理的生物伦理协议提供一种创新方法。我们旨在评估施用联苯菊酯（BF）期间笼养在稻田中的介壳虫的非致死生物标志物。我们分析了鱼皮粘液和血浆中与免疫系统、能量代谢和氧化应激有关的参数。暴露于联苯菊酯的鱼类皮肤粘液葡萄糖水平以及蛋白酶、碱性磷酸酶和超氧化物歧化酶的酶活性显著增加。在血浆参数方面，BF 提高了葡萄糖、总蛋白和白蛋白的水平，但降低了甘油三酯。此外，暴露鱼血浆中溶菌酶和碱性磷酸酶的活性也有所增加。我们的研究结果表明，原位暴露于 BF 的鱼类能量需求增加，免疫功能发生改变，并出现轻微的氧化应激反应。我们的研究表明，皮肤粘液和血浆是非常有前景的基质，可用于开发非致命性生物标记物，以评估鱼类在压力环境下的健康状况。

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.