Transcriptome analysis identifies CCDC86 as a new potential Head and Neck Squamous Cell Carcinoma biomarker

Abstract

OBJECTIVES

Overall, this comprehensive analysis aims to evaluate the expression profile of CCDC86 in Head and Neck Squamous Cell Carcinoma, providing insights into its potential as a diagnostic biomarker.

METHODS

Initially, we conducted transcriptomic integration analysis to examine CCDC86 expression in HNSCC using various datasets (RNA-seq) obtained from the gene expression profiling interactive analysis database. We also established the diagnostic significance of CCDC86 and coregulated genes in HNSCC through the Kaplan–Meier Plotter.

RESULTS

Initially, we detected elevated levels of CCDC86 in HNSCC, which correlated with lower survival rates (p=<0.001). We also identified seven genes coregulated with CCDC86 that were also overexpressed in HNSCC in comparison with normal tissues.

CONCLUSIONS

For the first time, our findings suggest that CCDC86 can be a new emerging biomarker with promising therapeutic values to HNSCC patients.

IMPLICATIONS

No further implications other than specified in conclusion.